Show simple item record

dc.contributor.authorNygaard, Nygaard
dc.contributor.authorSlettaløkken, Gunnar
dc.contributor.authorVegge, Geir
dc.contributor.authorHollan, Ivana
dc.contributor.authorWhist, Jon Elling
dc.date.accessioned2016-01-13T11:44:45Z
dc.date.available2016-01-13T11:44:45Z
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/11250/2373606
dc.description.abstractAbstract Purpose Irisin is a recently identified exercise-induced hormone that increases energy expenditure, at least in rodents. The main purpose of this study was to test the hypothesis that Irisin increases acutely in blood after singular sessions of intense endurance exercise (END) and heavy strength training (STR). Secondary, we wanted to explore the relationship between body composition and exercise-induced effects on irisin, and the effect of END and STR on muscular expression of the irisin gene FNDC5. Methods Nine moderately trained healthy subjects performed three test days using a randomized and standardized crossover design: one day with 60 minutes of END, one day with 60 minutes of STR, and one day without exercise (CON). Venous blood was sampled over a period of 24h on the exercise days. Results Both END and STR led to transient increases in irisin concentrations in blood, peaking immediately after END and one hour after STR, before gradually returning to baseline. Irisin responses to STR, but not END, showed a consistently strong negative correlation with proportions of lean body mass. Neither END nor STR affected expression of FNDC5, measured 4h after training sessions, though both protocols led to pronounced increases in PGC-1α expression, which is involved in transcriptional control of FNDC5. Conclusion The results strongly suggest that single sessions of intense endurance exercise and heavy strength training lead to transient increases in irisin concentrations in blood. This was not accompanied by increased FNDC5 expression, measured 4h post-exercise. The results suggest that irisin responses to resistance exercise are higher in individuals with lower proportions of lean body mass.nb_NO
dc.language.isoengnb_NO
dc.rightsNavngivelse 4.0 Internasjonal
dc.rights.urihttp://http://creativecommons.org/licenses/by/4.0/no
dc.titleIrisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Trainingnb_NO
dc.typeJournal article
dc.typePeer reviewednb_NO
dc.subject.nsiVDP::Medical disciplines: 700::Sports medicine: 850::Exercise techniques: 851nb_NO
dc.subject.nsiVDP::Medical disciplines: 700::Sports medicine: 850nb_NO
dc.source.volume10nb_NO
dc.source.journalPlos Onenb_NO
dc.source.issue3nb_NO
dc.identifier.doi. doi:10.1371/ journal.pone.0121367


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal