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dc.contributor.authorTekin, Hasim
dc.contributor.authorFrøbert, Ole
dc.contributor.authorGræsli, Anne Randi
dc.contributor.authorKindberg, Jonas
dc.contributor.authorBilgin, Mesut
dc.contributor.authorBuschard, Karsten
dc.coverage.spatialScandinaviaen_US
dc.date.accessioned2024-02-23T12:47:45Z
dc.date.available2024-02-23T12:47:45Z
dc.date.created2023-09-15T12:41:30Z
dc.date.issued2023
dc.identifier.citationPLOS ONE. 2023, 18 (9), e0291063-?.en_US
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/11250/3119673
dc.description.abstractBrown bears (Ursus arctos) prepare for winter by overeating and increasing adipose stores, before hibernating for up to six months without eating, drinking, and with minimal movement. In spring, the bears exit the den without any damage to organs or physiology. Recent clinical research has shown that specific lipids and lipid profiles are of special interest for diseases such as diabetes type 1 and 2. Furthermore, rodent experiments show that lipids such as sulfatide protects rodents against diabetes. As free-ranging bears experience fat accumulation and month-long physical inactivity without developing diabetes, they could possibly be affected by similar protective measures. In this study, we investigated whether lipid profiles of brown bears are related to protection against hibernation-induced damage. We sampled plasma from 10 free-ranging Scandinavian brown bears during winter hibernation and repeated sampling during active state in the summer period. With quantitative shotgun lipidomics and liquid chromatography-mass spectrometry, we profiled 314 lipid species from 26 lipid classes. A principal component analysis revealed that active and hibernation samples could be distinguished from each other based on their lipid profiles. Six lipid classes were significantly altered when comparing plasma from active state and hibernation: Hexosylceramide, phosphatidylglycerol, and lysophosphatidylglycerol were higher during hibernation, while phosphatidylcholine ether, phosphatidylethanolamine ether, and phosphatidylinositol were lower. Additionally, sulfatide species with shorter chain lengths were lower, while longer chain length sulfatides were higher during hibernation. Lipids that are altered in bears are described by others as relevant for and associated with diabetes, which strengthens their position as potential effectors during hibernation. From this analysis, a range of lipids are suggested as potential protectors of bear physiology, and of potential importance in diabetes.en_US
dc.language.isoengen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectUrsus arctosen_US
dc.subjectbrown bearen_US
dc.subjecthibernationen_US
dc.subjectdiabetesen_US
dc.titleHibernation and plasma lipids in free-ranging brown bears-implications for diabetesen_US
dc.title.alternativeHibernation and plasma lipids in free-ranging brown bears-implications for diabetesen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2023 Tekin et al.en_US
dc.subject.nsiVDP::Zoologiske og botaniske fag: 480en_US
dc.subject.nsiVDP::Zoology and botany: 480en_US
dc.source.pagenumbere0291063-?en_US
dc.source.volume18en_US
dc.source.journalPLOS ONEen_US
dc.source.issue9en_US
dc.identifier.doi10.1371/journal.pone.0291063
dc.identifier.cristin2175481
dc.relation.projectEgen institusjon: Norwegian institute for nature research (NINA)en_US
dc.relation.projectAndre: Swedish Environmental Protection Agency (SEPA): 333-22-001en_US
dc.relation.projectMiljødirektoratet: 23047010en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal