%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Sunniva Katharina Thode, Ewelina Rojek, Mikolaj Kozlowski, Rafi Ahmad, Peik Haugen
Distribution of siderophore gene systems on a Vibrionaceae phylogeny: Database searches, phylogenetic analyses and evolutionary perspectives
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 14 0 R/Contents 15 0 R/TrimBox[0 0 612 792]>>
endobj
14 0 obj
[16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R]
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref002)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref003)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref004)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref005)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref006)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref007)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref008)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref009)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref010)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref011)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref012)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref012)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref014)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref015)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref016)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref017)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref016)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref018)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref019)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref020)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref021)>>
endobj
38 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref022)>>
endobj
39 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref023)>>
endobj
40 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref024)>>
endobj
41 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref025)>>
endobj
42 0 obj
<>/Border[0 0 0]/A 43 0 R>>
endobj
43 0 obj
<>
endobj
15 0 obj
[44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R]
endobj
44 0 obj
<>stream
q
0.83 0.64 0.02 0 k
447.6472 674.9858 m
452.3528 674.9858 l
h
f*
203.4142 622.9984 m
208.1764 622.9984 l
h
f*
210.3874 622.9984 m
215.1496 622.9984 l
h
f*
564.3213 544.989 m
569.1969 544.989 l
h
f*
403.937 493.0016 m
408.8126 493.0016 l
h
f*
411.137 493.0016 m
416.0126 493.0016 l
h
f*
381.8268 466.9795 m
386.7024 466.9795 l
h
f*
540.7937 363.0047 m
545.5559 363.0047 l
h
f*
370.6016 297.978 m
375.4772 297.978 l
h
f*
377.8016 297.978 m
387.4961 297.978 l
h
f*
325.3606 284.9953 m
335.0551 284.9953 l
h
f*
540.5669 272.0126 m
550.2614 272.0126 l
h
f*
395.0929 245.9906 m
404.7874 245.9906 l
h
f*
410.0598 245.9906 m
419.7543 245.9906 l
h
f*
319.748 233.0079 m
329.4425 233.0079 l
h
f*
515.5654 220.0252 m
525.2598 220.0252 l
h
f*
410.4567 206.9858 m
420.1512 206.9858 l
h
f*
469.474 181.0205 m
479.1685 181.0205 l
h
f*
481.5496 181.0205 m
491.2441 181.0205 l
h
f*
429.2787 167.9811 m
438.9165 167.9811 l
h
f*
221.2157 154.9984 m
230.9102 154.9984 l
h
f*
233.2346 154.9984 m
242.9291 154.9984 l
h
f*
321.5055 154.9984 m
331.2 154.9984 l
h
f*
532.5732 154.9984 m
542.2677 154.9984 l
h
f*
533.4236 142.0157 m
543.1181 142.0157 l
h
f*
353.9906 103.011 m
363.685 103.011 l
h
f*
0 g
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 706.0535 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 689.1023 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Siderophores)Tj
5.4991 0 Td
(represent)Tj
3.9572 0 Td
(a)Tj
0.6519 0 Td
(group)Tj
2.6136 0 Td
(of)Tj
1.0148 0 Td
(relatively)Tj
3.838 0 Td
(small,)Tj
2.5512 0 Td
(and)Tj
1.7291 0 Td
(low)Tj
1.6611 0 Td
(molecular)Tj
4.2179 0 Td
(weight)Tj
2.8857 0 Td
(secondary)Tj
-30.6196 -1.3039 Td
(metabolites)Tj
4.8018 0 Td
(with)Tj
2.0013 0 Td
(high-affinity)Tj
5.2043 0 Td
(binding)Tj
3.3506 0 Td
(potential)Tj
3.7587 0 Td
(to)Tj
1.0261 0 Td
(ferric)Tj
2.3641 0 Td
(iron)Tj
1.9162 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.5987 0 Td
(They)Tj
2.2394 0 Td
(are)Tj
1.4456 0 Td
(produced)Tj
4.0479 0 Td
(and)Tj
-33.7547 -1.2982 Td
(secreted)Tj
3.4695 0 Td
(by)Tj
1.1849 0 Td
(a)Tj
0.652 0 Td
(broad)Tj
2.5681 0 Td
(range)Tj
2.4605 0 Td
(of)Tj
1.0148 0 Td
(microorganisms)Tj
6.7464 0 Td
(\(e.g.,)Tj
2.1203 0 Td
(bacteria)Tj
3.3789 0 Td
(and)Tj
1.7348 0 Td
(fungi\),)Tj
2.88 0 Td
(and)Tj
1.7291 0 Td
(some)Tj
2.3301 0 Td
(plants.)Tj
-32.2694 -1.2983 Td
(Under)Tj
2.8289 0 Td
(low)Tj
1.6554 0 Td
(iron)Tj
1.9106 0 Td
(conditions,)Tj
4.7055 0 Td
(such)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(in)Tj
1.0375 0 Td
(aquatic)Tj
3.1124 0 Td
(environments)Tj
5.7883 0 Td
(or)Tj
1.0998 0 Td
(inside)Tj
2.6136 0 Td
(a)Tj
0.6519 0 Td
(vertebrate)Tj
4.2293 0 Td
(host,)Tj
2.1373 0 Td
(e.g.,)Tj
-34.8432 -1.3039 Td
(bacteria)Tj
3.3788 0 Td
(must)Tj
2.2224 0 Td
(use)Tj
1.5363 0 Td
(highly)Tj
2.7099 0 Td
(specific)Tj
3.1862 0 Td
(strategies)Tj
3.9231 0 Td
(to)Tj
1.0261 0 Td
(acquire)Tj
3.1748 0 Td
(iron)Tj
1.9162 0 Td
(and)Tj
1.7291 0 Td
(other)Tj
2.3471 0 Td
(essential)Tj
3.583 0 Td
(micronutrients)Tj
-30.733 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
2.3017 0 Td
(To)Tj
1.3379 0 Td
(overcome)Tj
4.1499 0 Td
(iron)Tj
1.9162 0 Td
(starvation,)Tj
4.4164 0 Td
(siderophores)Tj
5.3858 0 Td
(are)Tj
1.4513 0 Td
(synthesized)Tj
4.8245 0 Td
(and)Tj
1.7291 0 Td
(secreted)Tj
3.4753 0 Td
(to)Tj
1.0205 0 Td
(their)Tj
2.1089 0 Td
(sur-)Tj
-34.1175 -1.2982 Td
(roundings)Tj
4.3426 0 Td
(where)Tj
2.6532 0 Td
(they)Tj
1.9219 0 Td
(chelate)Tj
2.999 0 Td
(ferric)Tj
2.3641 0 Td
(iron.)Tj
2.1373 0 Td
(Once)Tj
2.3641 0 Td
(bound,)Tj
3.0614 0 Td
(the)Tj
1.4683 0 Td
(ferric)Tj
2.3641 0 Td
(iron-siderophore)Tj
7.0696 0 Td
(complexes)Tj
-32.7456 -1.304 Td
(are)Tj
1.4456 0 Td
(recognized)Tj
4.5921 0 Td
(by)Tj
1.1792 0 Td
(siderophore)Tj
5.0286 0 Td
(receptors,)Tj
4.1386 0 Td
(and)Tj
1.7348 0 Td
(transported)Tj
4.8756 0 Td
(over)Tj
1.9785 0 Td
(the)Tj
1.4684 0 Td
(membrane)Tj
4.5637 0 Td
(by)Tj
1.1849 0 Td
(ABC)Tj
2.1486 0 Td
(trans-)Tj
-34.3386 -1.2982 Td
(porters)Tj
3.067 0 Td
(using)Tj
2.3924 0 Td
(TonB)Tj
2.4662 0 Td
(complexes)Tj
4.405 0 Td
(as)Tj
1.0148 0 Td
(energy)Tj
2.9083 0 Td
(transducers.)Tj
0.007 Tc
-15.0575 -1.2983 Td
(Interestingly,)Tj
5.6465 0 Td
(bacteria)Tj
3.4696 0 Td
(produce)Tj
3.5943 0 Td
(siderophores)Tj
5.5162 0 Td
(of)Tj
1.0375 0 Td
(several)Tj
3.0104 0 Td
(major)Tj
2.6645 0 Td
(classes,)Tj
3.1408 0 Td
(each)Tj
2.0749 0 Td
(of)Tj
1.0375 0 Td
(which)Tj
2.7042 0 Td
(can)Tj
-35.0926 -1.2983 Td
(have)Tj
2.1032 0 Td
(a)Tj
0.6633 0 Td
(diverse)Tj
3.1295 0 Td
(set)Tj
1.3323 0 Td
(of)Tj
1.0374 0 Td
(molecular)Tj
4.32 0 Td
(structures,)Tj
4.5297 0 Td
(presumably)Tj
4.989 0 Td
(because)Tj
3.4015 0 Td
(production)Tj
4.8246 0 Td
(of)Tj
1.0374 0 Td
(unique)Tj
3.0841 0 Td
(sidero-)Tj
-34.452 -1.3039 Td
(phores)Tj
2.9933 0 Td
(can)Tj
1.6554 0 Td
(provide)Tj
3.3676 0 Td
(individual)Tj
4.3993 0 Td
(bacteria)Tj
3.4639 0 Td
(with)Tj
2.041 0 Td
(an)Tj
1.2245 0 Td
(advantage)Tj
4.3427 0 Td
(in)Tj
1.0545 0 Td
(the)Tj
1.5023 0 Td
(competition)Tj
5.2214 0 Td
(with)Tj
2.0409 0 Td
(others)Tj
2.7723 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
-36.0791 -1.2982 Td
(For)Tj
1.6554 0 Td
(example,)Tj
3.8664 0 Td
(polymicrobial)Tj
5.93 0 Td
(studies)Tj
3.0614 0 Td
(have)Tj
2.1033 0 Td
(shown)Tj
2.9027 0 Td
(that)Tj
1.8255 0 Td
(siderophores)Tj
5.5162 0 Td
(from)Tj
2.2507 0 Td
(one)Tj
1.7291 0 Td
(species)Tj
3.0784 0 Td
(can)Tj
-33.9191 -1.2983 Td
(inhibit)Tj
2.9763 0 Td
(growth)Tj
3.1408 0 Td
(or)Tj
1.1225 0 Td
(functions)Tj
4.0875 0 Td
(of)Tj
1.0375 0 Td
(other)Tj
2.4038 0 Td
(species,)Tj
3.3108 0 Td
(e.g.)Tj
1.5987 0 Td
(low)Tj
1.6951 0 Td
(concentrations)Tj
6.3326 0 Td
(of)Tj
1.0375 0 Td
(avaroferrin)Tj
4.8075 0 Td
(from)Tj
/F13 1 Tf
2.2507 0 Td
[()5()6()]TJ
-35.8013 -1.3039 Td
[()3()16()6()15()4()4()]TJ
3.3221 0 Td
[()11()10( )2()6()]TJ
/F8 1 Tf
2.2904 0 Td
(inhibit)Tj
2.9764 0 Td
(swarming)Tj
4.2633 0 Td
(of)Tj
/F13 1 Tf
1.0318 0 Td
[(\n)53()14()11(\r)-9()4()]TJ
2.7892 0 Td
[()11()10( )-8()12()6()10()15()-15()7()4()1()-4()]TJ
/F8 1 Tf
5.2214 0 Td
(and)Tj
1.7632 0 Td
(a)Tj
0.6633 0 Td
(siderophore)Tj
5.1476 0 Td
(from)Tj
/F13 1 Tf
2.2507 0 Td
[()18()-3()2()4()4()11()6()11()6()]TJ
-31.7194 -1.2983 Td
[()-36()12()4()11(\r)20()8()-3()7()2()]TJ
/F8 1 Tf
4.541 0 Td
(inhibits)Tj
3.3506 0 Td
(growth)Tj
3.1407 0 Td
(of)Tj
/F13 1 Tf
1.0375 0 Td
[(\n)53()14()11(\r)-9()4()]TJ
2.7836 0 Td
[()16()13( )-8()12()4()4()4()16(\r)-9()12()]TJ
/F8 1 Tf
5.1874 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
2.3697 0 Td
(Such)Tj
2.2167 0 Td
(kin)Tj
1.5647 0 Td
(discrimination)Tj
6.2815 0 Td
(strategy)Tj
3.4129 0 Td
(can)Tj
-35.8863 -1.2982 Td
(however)Tj
3.685 0 Td
(be)Tj
1.1735 0 Td
(bypassed)Tj
3.8948 0 Td
(by)Tj
1.2019 0 Td
(cheaters,)Tj
4.6147 0 Td
(i.e.,)Tj
1.6441 0 Td
(bacteria)Tj
3.4639 0 Td
(expressing)Tj
4.5354 0 Td
(receptors)Tj
4.0139 0 Td
(on)Tj
1.2982 0 Td
(their)Tj
2.1657 0 Td
(surface)Tj
3.1237 0 Td
(with)Tj
-34.8148 -1.304 Td
(affinity)Tj
3.1521 0 Td
(to)Tj
1.0488 0 Td
(siderophores)Tj
5.5162 0 Td
(produced)Tj
4.1328 0 Td
(by)Tj
1.2019 0 Td
(others)Tj
2.778 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
1.644 0 Td
(This)Tj
2.0296 0 Td
(mechanism)Tj
4.9436 0 Td
(is)Tj
0.8731 0 Td
(also)Tj
1.8085 0 Td
(known)Tj
3.0614 0 Td
(as)Tj
1.0375 0 Td
(exogenous)Tj
-33.2275 -1.2982 Td
(or)Tj
1.1168 0 Td
(xeno-siderophore)Tj
7.4947 0 Td
(utilization.)Tj
4.6545 0 Td
(So)Tj
1.2246 0 Td
(surely,)Tj
2.9083 0 Td
(there)Tj
2.3187 0 Td
(must)Tj
2.2677 0 Td
(be)Tj
1.1736 0 Td
(a)Tj
0.6633 0 Td
(constant)Tj
3.7303 0 Td
(battle)Tj
2.4945 0 Td
(between)Tj
3.6057 0 Td
(microor-)Tj
-33.6527 -1.2983 Td
(ganisms)Tj
3.5546 0 Td
(for)Tj
1.4173 0 Td
(available)Tj
3.7644 0 Td
(iron,)Tj
2.194 0 Td
(and)Tj
1.7631 0 Td
(they)Tj
1.9672 0 Td
(can)Tj
1.6611 0 Td
(produce)Tj
3.5943 0 Td
(\(i\))Tj
1.2019 0 Td
(own)Tj
1.9899 0 Td
(siderophores)Tj
5.5162 0 Td
(and)Tj
1.7688 0 Td
(the)Tj
1.5024 0 Td
(respective)Tj
-31.8952 -1.2983 Td
(receptors,)Tj
4.2519 0 Td
(and/or)Tj
3.0047 0 Td
(\(ii\))Tj
1.474 0 Td
(cheating)Tj
4.5071 0 Td
(receptors)Tj
4.0138 0 Td
(for)Tj
1.4173 0 Td
(utilization)Tj
4.4164 0 Td
(of)Tj
1.0374 0 Td
(siderophores)Tj
5.5162 0 Td
(produced)Tj
4.1329 0 Td
(by)Tj
-33.7717 -1.3039 Td
(others.)Tj
-0.004 Tc
1.1962 -1.2982 Td
(We)Tj
1.61 0 Td
(have)Tj
2.0636 0 Td
(in)Tj
1.0318 0 Td
(this)Tj
1.6781 0 Td
(work,)Tj
2.5002 0 Td
(studied)Tj
3.1578 0 Td
(siderophore)Tj
5.0229 0 Td
(biosynthesis)Tj
5.1024 0 Td
(systems)Tj
3.2995 0 Td
(and)Tj
1.7291 0 Td
(their)Tj
2.1089 0 Td
(respective)Tj
4.184 0 Td
(recep-)Tj
-34.6845 -1.2983 Td
(tors)Tj
1.7574 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
/F13 1 Tf
1.4683 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.3745 0 Td
(family.)Tj
/F13 1 Tf
2.9536 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.3745 0 Td
(represents)Tj
4.32 0 Td
(a)Tj
0.6576 0 Td
(large)Tj
2.16 0 Td
(and)Tj
1.7291 0 Td
(diverse)Tj
3.0501 0 Td
(group)Tj
2.6078 0 Td
(of)Tj
1.0148 0 Td
(Gram-)Tj
-34.6731 -1.3039 Td
(negative)Tj
3.5319 0 Td
(Gammaproteobacteria)Tj
9.0084 0 Td
(,)Tj
0.4422 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4684 0 Td
(evolutionary)Tj
5.261 0 Td
(relationships)Tj
5.3462 0 Td
(between)Tj
3.5319 0 Td
(many)Tj
2.4775 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-33.8171 -1.2983 Td
(approximately)Tj
5.9753 0 Td
(140)Tj
1.6441 0 Td
(different)Tj
3.6567 0 Td
(species)Tj
2.999 0 Td
(were)Tj
2.1203 0 Td
(recently)Tj
3.4129 0 Td
(updated)Tj
3.4753 0 Td
(by)Tj
1.1792 0 Td
(Sawabe)Tj
3.1804 0 Td
(and)Tj
1.7292 0 Td
(coworkers)Tj
4.3653 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
1.5987 0 Td
(Rep-)Tj
-35.3364 -1.2983 Td
(resentatives)Tj
4.8812 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6781 0 Td
(family)Tj
2.7269 0 Td
(have)Tj
2.0636 0 Td
(been)Tj
2.1203 0 Td
(heavily)Tj
3.0274 0 Td
(studied,)Tj
3.3789 0 Td
(typically)Tj
3.5602 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0262 0 Td
(their)Tj
2.1089 0 Td
(ability)Tj
2.6929 0 Td
(to)Tj
1.0262 0 Td
(cause)Tj
2.3867 0 Td
(seri-)Tj
-35.3931 -1.3039 Td
(ous)Tj
1.6157 0 Td
(diseases)Tj
3.3789 0 Td
(in)Tj
1.0318 0 Td
(humans)Tj
3.4412 0 Td
(or)Tj
1.0998 0 Td
(animals.)Tj
0.005 Tc
-9.3712 -1.2982 Td
(The)Tj
1.8141 0 Td
(causative)Tj
3.9231 0 Td
(agent)Tj
2.4322 0 Td
(of)Tj
1.0318 0 Td
(the)Tj
1.4966 0 Td
(human)Tj
3.1238 0 Td
(disease)Tj
3.0841 0 Td
(cholera,)Tj
/F13 1 Tf
3.4469 0 Td
[(\n)53()14()11(\r)-9()4()]TJ
2.7723 0 Td
[()13()6()10()4()2(\r)20()6()]TJ
/F8 1 Tf
(,)Tj
3.7417 0 Td
(is)Tj
0.8617 0 Td
(the)Tj
1.4967 0 Td
(most)Tj
2.245 0 Td
(famous)Tj
/F13 1 Tf
-32.6662 -1.2983 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.4821 0 Td
(representative.)Tj
/F13 1 Tf
6.1965 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1282 0 Td
[()13()6()10()4()2(\r)20()6()]TJ
/F8 1 Tf
3.4979 0 Td
(produces)Tj
3.9515 0 Td
(the)Tj
1.4967 0 Td
(catechol)Tj
3.5773 0 Td
(siderophore)Tj
5.125 0 Td
(vibriobactin)Tj
-30.4552 -1.3039 Td
(using)Tj
2.4321 0 Td
(proteins)Tj
3.5886 0 Td
(encoded)Tj
3.6623 0 Td
(by)Tj
/F13 1 Tf
1.2019 0 Td
[()-13()14()-7()13()]TJ
/F8 1 Tf
5.828 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
2.8403 0 Td
(Ferric)Tj
2.6589 0 Td
(iron-vibriobactin)Tj
7.268 0 Td
(complexes)Tj
4.4844 0 Td
(are)Tj
1.4796 0 Td
(rec-)Tj
-35.4441 -1.2983 Td
(ognized)Tj
3.4355 0 Td
(by)Tj
1.1962 0 Td
(the)Tj
1.4967 0 Td
(receptor)Tj
3.6283 0 Td
(ViuA)Tj
2.4321 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(].)Tj
2.1204 0 Td
(Moreover,)Tj
/F13 1 Tf
4.4787 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1225 0 Td
[()13()6()10()4()2(\r)20()6()]TJ
/F8 1 Tf
3.5036 0 Td
(can)Tj
1.6554 0 Td
(cheat)Tj
3.1748 0 Td
(on)Tj
1.2926 0 Td
(derivatives)Tj
4.6034 0 Td
(of)Tj
-34.1402 -1.2982 Td
(enterobactin)Tj
5.3744 0 Td
(\(produced)Tj
4.4674 0 Td
(by)Tj
1.2019 0 Td
(e.g.,)Tj
/F13 1 Tf
1.8311 0 Td
[()-4()-3()13()6()2(\r)-9()4()13()18()4()]TJ
4.7282 0 Td
[()7()10()12()]TJ
/F8 1 Tf
(\))Tj
1.9389 0 Td
(using)Tj
2.4378 0 Td
(the)Tj
1.4966 0 Td
(receptors)Tj
3.9969 0 Td
(IrgA)Tj
2.1146 0 Td
(and)Tj
1.7575 0 Td
(VctA)Tj
2.3584 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(],)Tj
2.1203 0 Td
(flu-)Tj
-35.824 -1.2983 Td
(vibactin)Tj
3.4922 0 Td
(\(synthesized)Tj
5.2724 0 Td
(by)Tj
/F13 1 Tf
1.2019 0 Td
[(\n)53()14()11(\r)-9()4()]TJ
2.7723 0 Td
[()-36()12()15()-13()4()11()12()-4()]TJ
/F8 1 Tf
(\))Tj
3.6963 0 Td
(using)Tj
2.4378 0 Td
(the)Tj
1.4967 0 Td
(ViuA,)Tj
2.6645 0 Td
(VctA)Tj
2.3528 0 Td
(and)Tj
1.7574 0 Td
(IrgA)Tj
2.1203 0 Td
(receptors,)Tj
4.2293 0 Td
(and)Tj
-33.4939 -1.3039 Td
(finally)Tj
2.7665 0 Td
(ferrichrome)Tj
5.1137 0 Td
(by)Tj
1.1962 0 Td
(using)Tj
2.4378 0 Td
(the)Tj
1.4967 0 Td
(FhuA)Tj
2.5228 0 Td
(receptor)Tj
3.6283 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(].)Tj
/F13 1 Tf
3.617 0 Td
[(\n)53()14()11(\r)-9()4()]TJ
2.7723 0 Td
[()-13()4()12()18()12()-8()4()1()-4()]TJ
/F8 1 Tf
4.0648 0 Td
(represents)Tj
4.4107 0 Td
(another)Tj
-34.0268 -1.2983 Td
(significant)Tj
4.4843 0 Td
(human)Tj
3.1238 0 Td
(pathogen)Tj
4.0138 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
2.1203 0 Td
(This)Tj
2.0239 0 Td
(bacterium)Tj
4.371 0 Td
(produces)Tj
3.9515 0 Td
(the)Tj
1.4967 0 Td
(catechol)Tj
3.5773 0 Td
(siderophores)Tj
5.4935 0 Td
(vulni-)Tj
-34.6561 -1.2983 Td
(bactin)Tj
2.7495 0 Td
(by)Tj
1.2019 0 Td
(using)Tj
2.4321 0 Td
(proteins)Tj
3.5887 0 Td
(encoded)Tj
3.6623 0 Td
(by)Tj
1.2019 0 Td
(the)Tj
1.4967 0 Td
(gene)Tj
2.1146 0 Td
(cluster)Tj
2.9367 0 Td
(VV2_0830VV2_0844)Tj
9.8248 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(],)Tj
2.1203 0 Td
(and)Tj
-33.3295 -1.3039 Td
(recognizes)Tj
4.5127 0 Td
(ferri-vulnibactin)Tj
6.9675 0 Td
(via)Tj
1.4003 0 Td
(the)Tj
1.4967 0 Td
(VuuA)Tj
2.6929 0 Td
(receptor)Tj
3.6283 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
2.1203 0 Td
(It)Tj
0.8787 0 Td
(has)Tj
1.5648 0 Td
(also)Tj
1.8084 0 Td
(been)Tj
2.1544 0 Td
(proposed)Tj
4.0251 0 Td
(that)Tj
/F13 1 Tf
1.8142 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
-35.0643 -1.2982 Td
[()-13()4()12()18()12()-8()4()1()-4()]TJ
/F8 1 Tf
4.0648 0 Td
(produces)Tj
3.9515 0 Td
(an)Tj
1.2189 0 Td
(uncharacterized)Tj
6.7691 0 Td
(hydroxamate)Tj
5.5842 0 Td
(siderophore,)Tj
5.3574 0 Td
(and)Tj
1.7575 0 Td
(an)Tj
1.2189 0 Td
(uncharacterized)Tj
-29.9223 -1.2983 Td
(catechol)Tj
3.5716 0 Td
(siderophore)Tj
5.125 0 Td
(using,)Tj
2.6702 0 Td
(in)Tj
1.0545 0 Td
(part,)Tj
2.109 0 Td
(same)Tj
2.296 0 Td
(genes)Tj
2.4831 0 Td
(as)Tj
1.0375 0 Td
(for)Tj
1.4117 0 Td
(vulnibactin)Tj
4.8415 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
3.3222 0 Td
(Finally,)Tj
/F13 1 Tf
3.2428 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1282 0 Td
[()-13()4()12()18()12()-8()]TJ
-34.2933 -1.3039 Td
[()1()-4()]TJ
/F8 1 Tf
1.474 0 Td
(can)Tj
1.6554 0 Td
(transport)Tj
4.0081 0 Td
(and)Tj
1.7575 0 Td
(utilize)Tj
2.7213 0 Td
(aerobactin)Tj
4.524 0 Td
(\(IutA)Tj
2.4548 0 Td
(receptor\))Tj
3.9798 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(],)Tj
2.1203 0 Td
(deferoxamine)Tj
5.828 0 Td
(B)Tj
0.8107 0 Td
(\(DesA)Tj
2.8063 0 Td
(recep-)Tj
-34.1402 -1.2983 Td
(tor\))Tj
1.7688 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(])Tj
3.0954 0 Td
(and)Tj
1.7574 0 Td
(vibriobactin)Tj
5.1761 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
2.1259 0 Td
(The)Tj
1.8085 0 Td
(human)Tj
3.1238 0 Td
(pathogen)Tj
/F13 1 Tf
4.0082 0 Td
[(\n)53()14()11(\r)-9()4()]TJ
2.7779 0 Td
[( )4()16(\r)20()11()6()6()2()6()10()15()-15()7()4()1()-4()]TJ
/F8 1 Tf
7.2623 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(])Tj
-32.9043 -1.2983 Td
(produces)Tj
3.9514 0 Td
(the)Tj
1.4967 0 Td
(carboxylate)Tj
4.8812 0 Td
(siderophore)Tj
5.125 0 Td
(named)Tj
3.0161 0 Td
(vibrioferrin)Tj
4.9719 0 Td
(\(encoded)Tj
4.0139 0 Td
(by)Tj
/F13 1 Tf
1.2018 0 Td
[( )12()2()13()]TJ
/F8 1 Tf
(\))Tj
4.337 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
-32.995 -1.3039 Td
(Vibrioferrin)Tj
5.21 0 Td
(is)Tj
0.8674 0 Td
(sensitive)Tj
3.702 0 Td
(to)Tj
1.0432 0 Td
(photolysis)Tj
4.3596 0 Td
(and)Tj
1.7575 0 Td
(has)Tj
1.5704 0 Td
(a)Tj
0.6633 0 Td
(lower)Tj
2.4944 0 Td
(affinity)Tj
3.1408 0 Td
(for)Tj
1.4117 0 Td
(iron)Tj
1.9502 0 Td
(compared)Tj
4.3143 0 Td
(to)Tj
1.0431 0 Td
(other)Tj
2.3925 0 Td
(cat-)Tj
-35.9204 -1.2982 Td
(echol-type)Tj
4.4787 0 Td
(siderophores)Tj
5.4935 0 Td
(in)Tj
1.0545 0 Td
(vibrios.)Tj
3.2541 0 Td
(Ferri-vibrioferrin)Tj
7.336 0 Td
(is)Tj
0.8674 0 Td
(recognized)Tj
4.6772 0 Td
(and)Tj
1.7574 0 Td
(transported)Tj
4.9776 0 Td
(over)Tj
2.0126 0 Td
(the)Tj
-35.909 -1.2983 Td
(membranes)Tj
5.0059 0 Td
(using)Tj
2.4378 0 Td
(the)Tj
1.4967 0 Td
(receptor)Tj
3.6283 0 Td
(PvuA)Tj
2.4775 0 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(].)Tj
/F13 1 Tf
2.1259 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1225 0 Td
[( )4()16(\r)20()11()6()6()2()6()10()15()-15()7()4()1()-4()]TJ
/F8 1 Tf
7.268 0 Td
(can)Tj
1.6498 0 Td
(cheat)Tj
3.1748 0 Td
(using)Tj
2.4377 0 Td
(the)Tj
1.4967 0 Td
(exoge-)Tj
-34.3216 -1.2983 Td
(nous)Tj
2.1996 0 Td
(siderophores)Tj
5.4935 0 Td
(enterobactin,)Tj
5.6126 0 Td
(aerobactin,)Tj
4.7565 0 Td
(ferrichrome)Tj
5.1137 0 Td
(and)Tj
1.7574 0 Td
(possibly)Tj
3.515 0 Td
(vibriobactin)Tj
5.176 0 Td
(and)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 447.0803 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Sideropho)Tj
4.4716 0 Td
(re)Tj
1.0985 0 Td
(systems)Tj
3.8409 0 Td
(in)Tj
/F7 1 Tf
0.978 0 Td
(Vibrionac)Tj
4.0819 0 Td
(eae)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01918)Tj
4.089 0 Td
(60)Tj
0 g
2.0906 0 Td
(February)Tj
4.1599 0 Td
(14,)Tj
1.5874 0 Td
(2018)Tj
33.1585 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(20)Tj
/F10 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(transporter;)Tj
4.5638 0 Td
(BLASTp)Tj
2.9905 0 Td
(,)Tj
0.4465 0 Td
(Protein)Tj
2.8701 0 Td
(BLAST;)Tj
2.9693 0 Td
(G.)Tj
1.0276 0 Td
(sp,)Tj
/F11 1 Tf
-14.8678 -1.3748 Td
(Grimontia)Tj
/F10 1 Tf
3.8764 0 Td
(species;)Tj
3.2173 0 Td
(ML,)Tj
1.6725 0 Td
(Maximum)Tj
3.9898 0 Td
(Likelihood;)Tj
-12.756 -1.3749 Td
(MLSA,)Tj
2.7212 0 Td
(Multilocus)Tj
4.0749 0 Td
(sequen)Tj
2.6787 0 Td
(ce)Tj
1.063 0 Td
(alignment;)Tj
4.1032 0 Td
(NRPS,)Tj
-14.641 -1.3748 Td
(Non-Ribos)Tj
3.9897 0 Td
(omal)Tj
2.0623 0 Td
(Peptide)Tj
2.9835 0 Td
(Synthase;)Tj
3.8551 0 Td
(nt,)Tj
1.1764 0 Td
(nucleotide;)Tj
-14.067 -1.3748 Td
(P.)Tj
0.9708 0 Td
(sp,)Tj
/F11 1 Tf
1.3394 0 Td
(Photobact)Tj
3.7701 0 Td
(erium)Tj
/F10 1 Tf
2.367 0 Td
(species;)Tj
3.2244 0 Td
(V.)Tj
0.9638 0 Td
(sp,)Tj
/F11 1 Tf
1.3394 0 Td
(Vibrio)Tj
ET
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
endstream
endobj
62 0 obj
<>stream
endstream
endobj
63 0 obj
<>stream
endstream
endobj
64 0 obj
<>stream
endstream
endobj
65 0 obj
<>stream
endstream
endobj
66 0 obj
<>stream
endstream
endobj
67 0 obj
<>stream
endstream
endobj
68 0 obj
<>stream
endstream
endobj
69 0 obj
<>stream
BT
/F10 1 Tf
0 77.2163 Td
(species.)Tj
ET
Q
endstream
endobj
70 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 71 0 R/Contents 72 0 R/TrimBox[0 0 612 792]>>
endobj
71 0 obj
[73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R 100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R 107 0 R]
endobj
73 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref022)>>
endobj
74 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref026)>>
endobj
75 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref029)>>
endobj
76 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref030)>>
endobj
77 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref005)>>
endobj
78 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref031)>>
endobj
79 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref032)>>
endobj
80 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref033)>>
endobj
81 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref034)>>
endobj
82 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref035)>>
endobj
83 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref036)>>
endobj
84 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref037)>>
endobj
85 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref038)>>
endobj
86 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref030)>>
endobj
87 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref039)>>
endobj
88 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref040)>>
endobj
89 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref041)>>
endobj
90 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref042)>>
endobj
91 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref040)>>
endobj
92 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref043)>>
endobj
93 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref044)>>
endobj
94 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref045)>>
endobj
95 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref046)>>
endobj
96 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref047)>>
endobj
97 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref046)>>
endobj
98 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref048)>>
endobj
99 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref049)>>
endobj
100 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref049)>>
endobj
101 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref037)>>
endobj
102 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref038)>>
endobj
103 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref050)>>
endobj
104 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref051)>>
endobj
105 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref052)>>
endobj
106 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref007)>>
endobj
107 0 obj
<>/Border[0 0 0]/A 108 0 R>>
endobj
108 0 obj
<>
endobj
72 0 obj
[109 0 R 110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R 116 0 R 117 0 R 118 0 R 119 0 R 120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R 128 0 R 129 0 R 130 0 R 131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R 137 0 R]
endobj
109 0 obj
<>stream
q
0.83 0.64 0.02 0 k
249.2787 706.337 m
258.9732 706.337 l
h
f*
261.3543 706.337 m
271.0488 706.337 l
h
f*
276.2646 706.337 m
285.9591 706.337 l
h
f*
358.6394 693.2976 m
368.2772 693.2976 l
h
f*
257.9528 680.315 m
262.8283 680.315 l
h
f*
265.1528 680.315 m
274.8472 680.315 l
h
f*
373.663 667.3323 m
383.3575 667.3323 l
h
f*
385.7386 667.3323 m
395.4331 667.3323 l
h
f*
324.0567 628.3276 m
333.7512 628.3276 l
h
f*
390.0472 615.3449 m
399.7417 615.3449 l
h
f*
402.0661 615.3449 m
411.7606 615.3449 l
h
f*
222.2362 602.3055 m
231.9307 602.3055 l
h
f*
234.3118 602.3055 m
244.0063 602.3055 l
h
f*
336.3024 602.3055 m
345.9969 602.3055 l
h
f*
203.4709 563.3008 m
213.1654 563.3008 l
h
f*
215.5465 563.3008 m
225.2409 563.3008 l
h
f*
203.4709 537.3354 m
213.1654 537.3354 l
h
f*
411.7039 537.3354 m
421.3984 537.3354 l
h
f*
229.3228 511.3134 m
238.9606 511.3134 l
h
f*
368.7874 498.3307 m
378.4819 498.3307 l
h
f*
249.052 407.3386 m
258.7465 407.3386 l
h
f*
261.0709 407.3386 m
270.7654 407.3386 l
h
f*
542.6079 394.2992 m
552.3024 394.2992 l
h
f*
554.6835 394.2992 m
564.378 394.2992 l
h
f*
247.2945 342.3118 m
256.989 342.3118 l
h
f*
272.4094 316.3465 m
282.1039 316.3465 l
h
f*
217.7008 290.3244 m
227.3953 290.3244 l
h
f*
321.052 277.3417 m
330.7465 277.3417 l
h
f*
410.5701 251.3197 m
420.2646 251.3197 l
h
f*
422.6457 251.3197 m
432.3402 251.3197 l
h
f*
434.6646 251.3197 m
444.3591 251.3197 l
h
f*
439.2 225.2976 m
448.8945 225.2976 l
h
f*
244.9134 134.3055 m
254.6079 134.3055 l
h
f*
392.315 121.3228 m
397.1339 121.3228 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F8 1 Tf
1 TL
0.005 Tc
0 0 Td
(fluvibactin)Tj
4.5807 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(29)Tj
0 g
(].)Tj
/F13 1 Tf
4.8189 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1282 0 Td
[()11()10( )-8()12()6()10()15()-15()7()4()1()-4()]TJ
/F8 1 Tf
5.193 0 Td
(is)Tj
0.8674 0 Td
(an)Tj
1.2189 0 Td
(emerging)Tj
4.0762 0 Td
(foodborne)Tj
4.49 0 Td
(pathogen)Tj
4.0139 0 Td
(that)Tj
1.8141 0 Td
(causes)Tj
2.8063 0 Td
(gas-)Tj
-35.0076 -1.3039 Td
(troenteritis)Tj
4.7621 0 Td
(and)Tj
1.7575 0 Td
(peritonitis)Tj
4.4447 0 Td
(in)Tj
1.0545 0 Td
(humans)Tj
3.4922 0 Td
([)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(].)Tj
2.1203 0 Td
(The)Tj
1.8085 0 Td
(B522)Tj
2.2621 0 Td
(strain)Tj
2.5568 0 Td
(contains)Tj
3.6793 0 Td
(the)Tj
1.4967 0 Td
(vibrioferrin)Tj
4.972 0 Td
(biosyn-)Tj
-34.4067 -1.2982 Td
(thesis)Tj
2.5114 0 Td
(cluster)Tj
2.9367 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(],)Tj
2.8403 0 Td
(and)Tj
1.7575 0 Td
(can)Tj
1.6497 0 Td
(also)Tj
1.8028 0 Td
(utilize)Tj
2.727 0 Td
(siderophores)Tj
5.4935 0 Td
(synthesized)Tj
4.9266 0 Td
(by)Tj
/F13 1 Tf
1.1962 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1281 0 Td
[()13()6()10()4()2(\r)20()6()]TJ
/F8 1 Tf
(,)Tj
/F13 1 Tf
3.7361 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1282 0 Td
[()-36()12()15()-13()4()11()12()-4()]TJ
/F8 1 Tf
-33.8341 -1.2983 Td
(and)Tj
/F13 1 Tf
1.7574 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1225 0 Td
[( )4()16(\r)20()11()6()6()2()6()10()15()-15()7()4()1()-4()]TJ
/F8 1 Tf
7.268 0 Td
(and)Tj
1.7575 0 Td
(ferrichrome)Tj
5.1137 0 Td
([)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(33)Tj
0 g
(].)Tj
-15.8229 -1.2983 Td
(Several)Tj
/F13 1 Tf
3.1124 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.4822 0 Td
(fish)Tj
1.7007 0 Td
(pathogens)Tj
4.3824 0 Td
(have)Tj
2.0976 0 Td
(been)Tj
2.16 0 Td
(studied)Tj
3.2144 0 Td
(with)Tj
2.0353 0 Td
(respect)Tj
3.1011 0 Td
(to)Tj
1.0431 0 Td
(siderophore)Tj
5.1194 0 Td
(pro-)Tj
-34.6448 -1.3039 Td
(duction)Tj
3.3788 0 Td
(and)Tj
1.7575 0 Td
(utilization,)Tj
4.6318 0 Td
(e.g.,)Tj
/F13 1 Tf
1.8255 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1282 0 Td
[()16()13( )-8()12()4()4()4()16(\r)-9()12()]TJ
/F8 1 Tf
(,)Tj
5.4028 0 Td
(a)Tj
0.6576 0 Td
(pathogen)Tj
4.0138 0 Td
(causing)Tj
3.3109 0 Td
(haemorrhagic)Tj
5.9017 0 Td
(septicemia)Tj
4.5467 0 Td
(in)Tj
-36.5553 -1.2982 Td
(fish,)Tj
1.9332 0 Td
(bivalves)Tj
3.4412 0 Td
(and)Tj
1.7575 0 Td
(crustaceans)Tj
4.9209 0 Td
([)Tj
0.83 0.64 0.02 0 k
(34)Tj
0 g
(],)Tj
/F13 1 Tf
2.126 0 Td
[()20()12()12()15()-13()14()11(\r)-9()4()]TJ
4.0025 0 Td
[()-3()11()12()6()11()18()4()1()4()4()]TJ
/F8 1 Tf
(,)Tj
5.261 0 Td
(causing)Tj
3.3109 0 Td
(cold-water)Tj
4.5751 0 Td
(vibriosis)Tj
3.6623 0 Td
(in)Tj
-34.9906 -1.2983 Td
(Atlantic)Tj
3.4922 0 Td
(salmon)Tj
3.1861 0 Td
(at)Tj
0.9751 0 Td
(low)Tj
1.6838 0 Td
(seawater)Tj
3.719 0 Td
(temperatures)Tj
5.5956 0 Td
([)Tj
0.83 0.64 0.02 0 k
(35)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(36)Tj
0 g
(],)Tj
/F13 1 Tf
3.3279 0 Td
[()4()6()12()11()13()4()6()-4()11()2(\r)-9()12()12()]TJ
6.5876 0 Td
[()4()16()-3()15()4()6()]TJ
3.8891 0 Td
[()10()14()7()10( )]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
2.6362 0 Td
[( )11()-4()-3()1()]TJ
-35.0926 -1.3039 Td
[()1()4()4()]TJ
/F8 1 Tf
1.8765 0 Td
([)Tj
0.83 0.64 0.02 0 k
(37)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(38)Tj
0 g
(],)Tj
3.3222 0 Td
(and)Tj
/F13 1 Tf
1.7574 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1282 0 Td
[()11()10( )-8()12()6()10()15()-15()7()4()1()-4()]TJ
/F8 1 Tf
5.1987 0 Td
([)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(].)Tj
2.1203 0 Td
(Depending)Tj
4.7565 0 Td
(on)Tj
1.2926 0 Td
(strain,)Tj
/F13 1 Tf
2.7893 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1282 0 Td
[()16()13( )-8()12()4()4()4()16(\r)-9()12()]TJ
/F8 1 Tf
5.1647 0 Td
(can)Tj
1.6554 0 Td
(synthesize)Tj
-32.19 -1.2983 Td
(and)Tj
1.7574 0 Td
(utilize)Tj
2.7269 0 Td
(the)Tj
1.4967 0 Td
(mixed)Tj
2.7666 0 Td
(catechol/hydroxamate)Tj
9.2749 0 Td
(siderophore)Tj
5.125 0 Td
(anguibactin)Tj
5.04 0 Td
(\(only)Tj
2.3584 0 Td
(serotype)Tj
3.651 0 Td
(O1)Tj
-34.1969 -1.2983 Td
(strain;)Tj
2.7892 0 Td
(biosynthesis)Tj
5.2101 0 Td
(encoded)Tj
3.6623 0 Td
(by)Tj
/F13 1 Tf
1.2019 0 Td
[()16()13( )-7()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 367.4834 581.8393 cm
BT
/F13 1 Tf
1 TL
0.0067 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 371.7921 577.4173 cm
BT
/F8 1 Tf
1 TL
0.005 Tc
0 0 Td
(/)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 375.1937 575.7165 cm
BT
/F13 1 Tf
1 TL
0.0067 Tc
0 0 Td
[(!)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 380.3527 577.4173 cm
BT
/F13 1 Tf
1 TL
0.005 Tc
0 0 Td
[("#$%&)]TJ
/F8 1 Tf
5.1533 0 Td
(and)Tj
1.7575 0 Td
(recognized)Tj
4.6828 0 Td
(by)Tj
1.1962 0 Td
(FatA)Tj
2.1997 0 Td
(receptor\))Tj
-33.0234 -1.3039 Td
([)Tj
0.83 0.64 0.02 0 k
(39)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(40)Tj
0 g
(],)Tj
3.3222 0 Td
(or)Tj
1.1169 0 Td
(vanchrobactin)Tj
6.0831 0 Td
(\(found)Tj
3.0104 0 Td
(in)Tj
1.0544 0 Td
(all)Tj
1.1736 0 Td
(serotype)Tj
3.6509 0 Td
(O2)Tj
1.457 0 Td
(strains,)Tj
3.1634 0 Td
(some)Tj
2.3641 0 Td
(plasmid)Tj
3.4582 0 Td
(less)Tj
1.6441 0 Td
(O1)Tj
1.4627 0 Td
(strains,)Tj
-32.961 -1.2982 Td
(and)Tj
1.7575 0 Td
(several)Tj
2.9934 0 Td
(other)Tj
2.3924 0 Td
(serotypes\).)Tj
4.6034 0 Td
(Biosynthesis)Tj
5.2838 0 Td
(of)Tj
1.0317 0 Td
(the)Tj
1.4967 0 Td
(latter)Tj
2.3471 0 Td
(is)Tj
0.8673 0 Td
(encoded)Tj
3.6624 0 Td
(by)Tj
/F13 1 Tf
1.2019 0 Td
[()4()12( )]TJ
/F8 1 Tf
2.4491 0 Td
(and)Tj
/F13 1 Tf
1.7575 0 Td
[()3()22()-7()]TJ
/F8 1 Tf
-31.8442 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(41)Tj
0 g
(],)Tj
2.1203 0 Td
(and)Tj
1.7575 0 Td
(recognized)Tj
4.6828 0 Td
(by)Tj
1.1962 0 Td
(a)Tj
0.6633 0 Td
(receptor)Tj
3.6284 0 Td
(encoded)Tj
3.6623 0 Td
(by)Tj
/F13 1 Tf
1.2018 0 Td
[()-22()-15()]TJ
/F8 1 Tf
1.9049 0 Td
([)Tj
0.83 0.64 0.02 0 k
(42)Tj
0 g
(]\).)Tj
2.4717 0 Td
(Anguibactin)Tj
5.2895 0 Td
(biosynthesis)Tj
5.2157 0 Td
(genes)Tj
2.4831 0 Td
(are)Tj
-36.2775 -1.3039 Td
(located)Tj
3.1408 0 Td
(both)Tj
2.0976 0 Td
(on)Tj
1.2926 0 Td
(a)Tj
0.6633 0 Td
(conjugative)Tj
4.9266 0 Td
(plasmid)Tj
3.4526 0 Td
(named)Tj
3.0216 0 Td
(pJM1,)Tj
2.7042 0 Td
(and)Tj
1.7575 0 Td
(on)Tj
1.2926 0 Td
(chromosomes)Tj
5.947 0 Td
(\()Tj
/F13 1 Tf
[()16()13( )-7()]TJ
/F8 1 Tf
3.8948 0 Td
(and)Tj
/F13 1 Tf
-34.1912 -1.2983 Td
[()16()13( )]TJ
/F8 1 Tf
(\))Tj
2.5796 0 Td
([)Tj
0.83 0.64 0.02 0 k
(40)Tj
0 g
(].)Tj
2.1203 0 Td
(Intriguingly,)Tj
5.3631 0 Td
(for)Tj
/F13 1 Tf
1.4116 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1282 0 Td
[()16()13( )-8()12()4()4()4()16(\r)-9()12()]TJ
/F8 1 Tf
5.1647 0 Td
(strain)Tj
2.5567 0 Td
(775)Tj
1.6725 0 Td
(the)Tj
1.4966 0 Td
(presence)Tj
3.7814 0 Td
(of)Tj
1.0375 0 Td
(pJM1)Tj
2.4661 0 Td
(and)Tj
1.7575 0 Td
(anguibactin)Tj
-32.5358 -1.2982 Td
(coincides)Tj
4.0422 0 Td
(with)Tj
2.0353 0 Td
(the)Tj
1.491 0 Td
(lack)Tj
1.8539 0 Td
(of)Tj
1.0261 0 Td
(vanchrobactin)Tj
6.0774 0 Td
([)Tj
0.83 0.64 0.02 0 k
(43)Tj
0 g
(].)Tj
2.1202 0 Td
(Its)Tj
1.2416 0 Td
(chromosome)Tj
5.5729 0 Td
(contains)Tj
3.6793 0 Td
(entire)Tj
2.6022 0 Td
(vanchrobactin)Tj
-31.7421 -1.2983 Td
(gene)Tj
2.1147 0 Td
(cluster,)Tj
3.1691 0 Td
(except)Tj
2.8233 0 Td
(that)Tj
/F13 1 Tf
1.8141 0 Td
[()3()22()]TJ
/F8 1 Tf
2.1714 0 Td
(is)Tj
0.8674 0 Td
(interrupted)Tj
4.8925 0 Td
(by)Tj
1.2018 0 Td
(an)Tj
1.2189 0 Td
(RS1)Tj
1.8198 0 Td
(transposon)Tj
4.7622 0 Td
(originating)Tj
4.7565 0 Td
(from)Tj
2.245 0 Td
(pJM1.)Tj
-33.8567 -1.3039 Td
(Closely)Tj
3.1862 0 Td
(related)Tj
3.0047 0 Td
(strains)Tj
2.9253 0 Td
(that)Tj
1.8142 0 Td
(lacks)Tj
2.228 0 Td
(this)Tj
1.7064 0 Td
(plasmid)Tj
3.4582 0 Td
(produce)Tj
3.5773 0 Td
(vanchrobactin.)Tj
6.3212 0 Td
(The)Tj
1.8085 0 Td
(authors)Tj
3.3052 0 Td
(therefore)Tj
-33.3352 -1.2983 Td
(hypothesize)Tj
5.04 0 Td
(that)Tj
1.8142 0 Td
(vanchrobactin)Tj
6.0831 0 Td
(was)Tj
1.7234 0 Td
(produced)Tj
4.1158 0 Td
(by)Tj
1.2019 0 Td
(the)Tj
1.4967 0 Td
(bacterium)Tj
4.371 0 Td
(prior)Tj
2.3017 0 Td
(to)Tj
1.0431 0 Td
(the)Tj
1.4967 0 Td
(acquisition)Tj
4.7282 0 Td
(of)Tj
-35.4158 -1.2983 Td
(pJM1)Tj
2.4718 0 Td
(\(and)Tj
2.1033 0 Td
(thus)Tj
1.9729 0 Td
(the)Tj
1.4967 0 Td
(anguibactin)Tj
5.04 0 Td
(cluster\),)Tj
3.5149 0 Td
(and)Tj
1.7574 0 Td
(that)Tj
1.8142 0 Td
(production)Tj
4.8075 0 Td
(of)Tj
1.0318 0 Td
(vanchrobactin)Tj
6.0831 0 Td
(at)Tj
0.9694 0 Td
(some)Tj
-33.063 -1.3039 Td
(point)Tj
2.4038 0 Td
(was)Tj
1.7235 0 Td
(suppressed)Tj
4.6998 0 Td
(by)Tj
1.2019 0 Td
(inactivation)Tj
5.0739 0 Td
(of)Tj
/F13 1 Tf
1.0318 0 Td
[()3()22()]TJ
/F8 1 Tf
2.1713 0 Td
(since)Tj
2.2904 0 Td
(anguibactin)Tj
5.0399 0 Td
(has)Tj
1.5704 0 Td
(a)Tj
0.6576 0 Td
(higher)Tj
2.8573 0 Td
(affinity)Tj
3.1408 0 Td
(for)Tj
1.4117 0 Td
(iron.)Tj
-35.2741 -1.2982 Td
(Moreover,)Tj
/F13 1 Tf
4.4788 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1225 0 Td
[()16()13( )-8()12()4()4()4()16(\r)-9()12()]TJ
/F8 1 Tf
5.1647 0 Td
(utilizes)Tj
3.0954 0 Td
(exogenous)Tj
4.5296 0 Td
(siderophores)Tj
5.4935 0 Td
(like)Tj
1.6895 0 Td
(enterobactin,)Tj
5.6125 0 Td
(ferrichrome)Tj
-31.1865 -1.2983 Td
(and)Tj
1.7575 0 Td
(citrate)Tj
2.795 0 Td
([)Tj
0.83 0.64 0.02 0 k
(44)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(45)Tj
0 g
(].)Tj
/F13 1 Tf
3.3278 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1169 0 Td
[()-3()11()12()6()11()18()4()1()4()4()]TJ
/F8 1 Tf
5.0286 0 Td
(synthesizes)Tj
4.7564 0 Td
(and)Tj
1.7575 0 Td
(utilizes)Tj
3.0954 0 Td
(the)Tj
1.4967 0 Td
(di-hydroxamate)Tj
6.7577 0 Td
(siderophore)Tj
-31.8895 -1.3039 Td
(bisucaberin)Tj
4.955 0 Td
(\(biosynthesis)Tj
5.5615 0 Td
(encoded)Tj
3.6624 0 Td
(by)Tj
/F13 1 Tf
1.2018 0 Td
[()11()14()-7()]TJ
/F8 1 Tf
3.3335 0 Td
(and)Tj
1.7574 0 Td
(recognized)Tj
4.6828 0 Td
(by)Tj
1.1962 0 Td
(the)Tj
1.4967 0 Td
(BitA)Tj
2.0863 0 Td
(receptor\))Tj
3.9798 0 Td
([)Tj
0.83 0.64 0.02 0 k
(46)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(47)Tj
0 g
(].)Tj
-33.9134 -1.2983 Td
(It)Tj
0.8731 0 Td
(has)Tj
1.5647 0 Td
(been)Tj
2.1543 0 Td
(postulated)Tj
4.4447 0 Td
(that)Tj
1.8142 0 Td
(the)Tj
1.491 0 Td
(siderophore)Tj
5.1194 0 Td
(production)Tj
4.8017 0 Td
(is)Tj
0.8617 0 Td
(vital)Tj
1.9616 0 Td
(for)Tj
1.406 0 Td
(the)Tj
1.4967 0 Td
(virulence)Tj
3.9798 0 Td
(of)Tj
/F13 1 Tf
1.0318 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1112 0 Td
[()-3()11()12()6()11()18()]TJ
-34.1119 -1.2982 Td
[()1()4()4()]TJ
/F8 1 Tf
(.)Tj
2.109 0 Td
(This)Tj
2.0239 0 Td
(assumption)Tj
4.9493 0 Td
(is)Tj
0.8674 0 Td
(based)Tj
2.5171 0 Td
(on)Tj
1.2926 0 Td
(that)Tj
1.8142 0 Td
(production)Tj
4.8074 0 Td
(of)Tj
1.0318 0 Td
(significant)Tj
4.4901 0 Td
(amounts)Tj
3.7757 0 Td
(of)Tj
1.0318 0 Td
(bisucaberin)Tj
4.9606 0 Td
(is)Tj
-35.6709 -1.2983 Td
(restricted)Tj
4.0762 0 Td
(to)Tj
1.0432 0 Td
(low)Tj
1.6838 0 Td
(temperature)Tj
5.227 0 Td
(conditions)Tj
4.5638 0 Td
(\(i.e.,)Tj
1.9841 0 Td
(the)Tj
1.4967 0 Td
(bacterium)Tj
4.371 0 Td
(only)Tj
2.0126 0 Td
(causes)Tj
2.8062 0 Td
(disease)Tj
3.0785 0 Td
(at)Tj
0.9694 0 Td
(low)Tj
1.6838 0 Td
(tem-)Tj
-34.9963 -1.3039 Td
(peratures\))Tj
4.3767 0 Td
([)Tj
0.83 0.64 0.02 0 k
(46)Tj
0 g
(].)Tj
2.1203 0 Td
(Also,)Tj
2.2904 0 Td
(we)Tj
1.3436 0 Td
(recently)Tj
3.4809 0 Td
(showed)Tj
3.3052 0 Td
(that)Tj
1.8141 0 Td
(the)Tj
1.4967 0 Td
(genes)Tj
2.4888 0 Td
(responsible)Tj
4.8528 0 Td
(for)Tj
1.4117 0 Td
(bisucaberin)Tj
4.9549 0 Td
(produc-)Tj
-33.9361 -1.2983 Td
(tion)Tj
1.8766 0 Td
(are)Tj
1.474 0 Td
(highly)Tj
2.7609 0 Td
(up-regulated)Tj
5.4425 0 Td
(under)Tj
2.6645 0 Td
(low)Tj
1.6838 0 Td
(iron)Tj
1.9502 0 Td
(conditions)Tj
4.5637 0 Td
(and)Tj
1.7575 0 Td
(that)Tj
1.8141 0 Td
(the)Tj
1.4967 0 Td
(production)Tj
4.8075 0 Td
(is)Tj
0.8674 0 Td
(strongly)Tj
-33.1594 -1.2983 Td
(regulated)Tj
4.0196 0 Td
(by)Tj
1.1962 0 Td
(Fur)Tj
1.6724 0 Td
([)Tj
0.83 0.64 0.02 0 k
(48)Tj
0 g
(].)Tj
2.126 0 Td
(A)Tj
0.9127 0 Td
(system)Tj
2.9934 0 Td
(for)Tj
1.4116 0 Td
(aerobactin)Tj
4.524 0 Td
(synthesis)Tj
3.9004 0 Td
(is)Tj
0.8674 0 Td
(in)Tj
1.0545 0 Td
(contrast)Tj
3.532 0 Td
(not)Tj
1.6044 0 Td
(expressed,)Tj
4.405 0 Td
(proba-)Tj
-34.2196 -1.3039 Td
(bly)Tj
1.4514 0 Td
(because)Tj
3.3845 0 Td
(the)Tj
1.4967 0 Td
(cluster)Tj
2.9367 0 Td
(is)Tj
0.8617 0 Td
(non-functional)Tj
6.3893 0 Td
(due)Tj
1.729 0 Td
(to)Tj
1.0431 0 Td
(frameshift)Tj
4.388 0 Td
(mutations)Tj
4.3597 0 Td
(and)Tj
1.7575 0 Td
(loss)Tj
1.7347 0 Td
(of)Tj
1.0319 0 Td
(the)Tj
1.4966 0 Td
(promo-)Tj
-34.0608 -1.2982 Td
(tor)Tj
1.423 0 Td
([)Tj
0.83 0.64 0.02 0 k
(49)Tj
0 g
(].)Tj
2.1203 0 Td
(The)Tj
1.8085 0 Td
(genome)Tj
3.4639 0 Td
(of)Tj
/F13 1 Tf
1.0318 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1169 0 Td
[()-3()11()12()6()11()18()4()1()4()4()]TJ
/F8 1 Tf
5.0286 0 Td
(also)Tj
1.8028 0 Td
(encodes)Tj
3.4979 0 Td
(the)Tj
1.4967 0 Td
(deferroxamine)Tj
6.2078 0 Td
(B)Tj
0.8107 0 Td
(receptor)Tj
3.6283 0 Td
(DesA)Tj
2.4605 0 Td
(and)Tj
-35.8977 -1.2983 Td
(the)Tj
1.4967 0 Td
(aerobactin)Tj
4.5241 0 Td
(receptor)Tj
3.6283 0 Td
(IutA)Tj
2.1033 0 Td
([)Tj
0.83 0.64 0.02 0 k
(49)Tj
0 g
(].)Tj
2.1203 0 Td
(The)Tj
1.8142 0 Td
(fish)Tj
1.6951 0 Td
(pathogen)Tj
/F13 1 Tf
4.0137 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0148 0 Td
[()4()16()-3()15()4()6()]TJ
3.8891 0 Td
[()10()14()7()10( )]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
2.6362 0 Td
[( )11()-4()-3()1()4()1()4()4()]TJ
/F8 1 Tf
3.634 0 Td
(produces)Tj
-32.5698 -1.3039 Td
(the)Tj
1.4967 0 Td
(mixed)Tj
2.7666 0 Td
(carboxylate/hydroxam)Tj
9.1842 0 Td
(ate)Tj
1.4003 0 Td
(siderophore)Tj
5.1249 0 Td
(piscibactin)Tj
4.6318 0 Td
(\(encoded)Tj
4.0139 0 Td
(by)Tj
/F13 1 Tf
1.1962 0 Td
[()4()12( )]TJ
/F8 1 Tf
2.4548 0 Td
(and)Tj
/F13 1 Tf
-32.2694 -1.2983 Td
[()12(\r)-20( '\(\)*+,)]TJ
/F8 1 Tf
(\),)Tj
4.7792 0 Td
(which)Tj
2.6929 0 Td
(is)Tj
0.8674 0 Td
(probably)Tj
3.8381 0 Td
(transported)Tj
4.9719 0 Td
(by)Tj
1.2018 0 Td
(FrpA)Tj
2.3584 0 Td
([)Tj
0.83 0.64 0.02 0 k
(37)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(38)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(50)Tj
0 g
(].)Tj
4.5298 0 Td
(The)Tj
1.8085 0 Td
(shrimp)Tj
3.1351 0 Td
(pathogen)Tj
/F13 1 Tf
4.0138 0 Td
[(\n)53()14()11(\r)-9()4()]TJ
-34.1969 -1.2983 Td
[()7()16()15( )13()4()15()4()12()]TJ
/F8 1 Tf
4.0196 0 Td
(produces)Tj
3.9458 0 Td
(the)Tj
1.4966 0 Td
(catechol)Tj
3.5773 0 Td
(siderophore)Tj
5.1249 0 Td
(amphi-enterobactin)Tj
8.3452 0 Td
(\(biosynthesis)Tj
5.5615 0 Td
(encoded)Tj
3.668 0 Td
(by)Tj
/F13 1 Tf
-35.7389 -1.3039 Td
[()6()20()-7(!)]TJ
/F8 1 Tf
(\),)Tj
5.2951 0 Td
(however)Tj
3.6737 0 Td
(the)Tj
1.4967 0 Td
(receptor)Tj
3.6283 0 Td
(has)Tj
1.5704 0 Td
(not)Tj
1.5987 0 Td
(been)Tj
2.1599 0 Td
(identified)Tj
4.1499 0 Td
([)Tj
0.83 0.64 0.02 0 k
(51)Tj
0 g
(].)Tj
2.1203 0 Td
(In)Tj
1.1282 0 Td
(addition,)Tj
/F13 1 Tf
3.9004 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
-30.7216 -1.2982 Td
(representatives)Tj
6.3326 0 Td
(may)Tj
1.9559 0 Td
(produce)Tj
3.5773 0 Td
(other)Tj
2.3924 0 Td
(siderophores)Tj
5.4934 0 Td
(such)Tj
2.0977 0 Td
(as)Tj
1.0318 0 Td
(amphibactins,)Tj
5.9697 0 Td
(deferroaxamines,)Tj
7.251 0 Td
(tri-)Tj
-36.1018 -1.2983 Td
(vanchrobactins,)Tj
6.6841 0 Td
(ochrobactins)Tj
5.5048 0 Td
(and)Tj
1.7575 0 Td
(probably)Tj
3.8381 0 Td
(several)Tj
2.9933 0 Td
(more.)Tj
2.6135 0 Td
(However,)Tj
4.1499 0 Td
(although)Tj
3.8267 0 Td
(the)Tj
1.4967 0 Td
(biosyn-)Tj
-32.8646 -1.2983 Td
(thetic)Tj
2.5115 0 Td
(gene)Tj
2.1147 0 Td
(clusters)Tj
3.3051 0 Td
(responsible)Tj
4.8529 0 Td
(for)Tj
1.4117 0 Td
(production)Tj
4.8074 0 Td
(of)Tj
1.0318 0 Td
(these)Tj
2.3017 0 Td
(molecules)Tj
4.2746 0 Td
(are)Tj
1.4797 0 Td
(well)Tj
1.8539 0 Td
(known)Tj
3.05 0 Td
(from)Tj
2.2394 0 Td
(other)Tj
-35.2344 -1.3039 Td
(bacteria,)Tj
3.6851 0 Td
(they)Tj
1.9615 0 Td
(may)Tj
1.9503 0 Td
(not)Tj
1.6043 0 Td
(have)Tj
2.092 0 Td
(been)Tj
2.16 0 Td
(conclusively)Tj
5.2099 0 Td
(identified)Tj
4.1499 0 Td
(in)Tj
/F13 1 Tf
1.0545 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
(.)Tj
5.7203 0 Td
(In)Tj
/F13 1 Tf
1.1225 0 Td
[(\n)53()14()11(\r)-9()4()]TJ
2.7723 0 Td
[()7()16()15( )13()4()15()4()12()12()]TJ
/F8 1 Tf
-33.4826 -1.2982 Td
(DS40M4,)Tj
4.0366 0 Td
(the)Tj
1.4966 0 Td
(same)Tj
2.2961 0 Td
(gene)Tj
2.1146 0 Td
(cluster)Tj
2.9367 0 Td
(is)Tj
0.8674 0 Td
(responsible)Tj
4.8528 0 Td
(for)Tj
1.4116 0 Td
(production)Tj
4.8019 0 Td
(of)Tj
1.0375 0 Td
(both)Tj
2.0919 0 Td
(vanchrobactin)Tj
6.0831 0 Td
(and)Tj
1.7575 0 Td
(tri-)Tj
-35.7843 -1.2983 Td
(vanchrobactin,)Tj
6.3156 0 Td
(but)Tj
1.5817 0 Td
(the)Tj
1.4967 0 Td
(main)Tj
2.3244 0 Td
(determinant)Tj
5.2781 0 Td
(that)Tj
1.814 0 Td
(regulates)Tj
3.8495 0 Td
(which)Tj
2.6985 0 Td
(of)Tj
1.0318 0 Td
(them)Tj
2.3244 0 Td
(is)Tj
0.8674 0 Td
(produced)Tj
4.1159 0 Td
(remains)Tj
-33.698 -1.3039 Td
(unknown)Tj
4.1443 0 Td
([)Tj
0.83 0.64 0.02 0 k
(52)Tj
0 g
(].)Tj
2.1203 0 Td
(Payne)Tj
2.6872 0 Td
(and)Tj
1.7575 0 Td
(co-workers)Tj
4.8018 0 Td
(recently)Tj
3.4809 0 Td
(reviewed)Tj
3.8664 0 Td
(siderophore)Tj
5.125 0 Td
(biosynthesis)Tj
5.21 0 Td
(and)Tj
1.7575 0 Td
(utili-)Tj
-34.9509 -1.2983 Td
(zation)Tj
2.7383 0 Td
(in)Tj
/F13 1 Tf
1.0545 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
(,)Tj
5.7146 0 Td
(with)Tj
2.0296 0 Td
(a)Tj
0.6633 0 Td
(focus)Tj
2.3697 0 Td
(on)Tj
1.2926 0 Td
(vibrios)Tj
3.016 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
1.6384 0 Td
(This)Tj
2.0182 0 Td
(inspired)Tj
3.5773 0 Td
(us)Tj
1.1226 0 Td
(to)Tj
1.0431 0 Td
(use)Tj
1.559 0 Td
(the)Tj
1.4911 0 Td
(existing)Tj
3.3902 0 Td
(knowl-)Tj
-34.7185 -1.2983 Td
(edge)Tj
2.092 0 Td
(to)Tj
1.0431 0 Td
(investigate)Tj
4.5638 0 Td
(the)Tj
1.4967 0 Td
(distribution)Tj
5.074 0 Td
(and)Tj
1.7574 0 Td
(evolution)Tj
4.0818 0 Td
(of)Tj
1.0318 0 Td
(the)Tj
1.4967 0 Td
(different)Tj
3.736 0 Td
(siderophore)Tj
5.125 0 Td
(systems)Tj
-31.4983 -1.3039 Td
(further.)Tj
3.3222 0 Td
(In)Tj
1.1282 0 Td
(this)Tj
1.7121 0 Td
(work,)Tj
2.5455 0 Td
(we)Tj
1.3493 0 Td
(first)Tj
1.8482 0 Td
(performed)Tj
4.5524 0 Td
(literature)Tj
3.9684 0 Td
(searches)Tj
3.617 0 Td
(on)Tj
/F13 1 Tf
1.2926 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.4878 0 Td
(siderophore)Tj
-30.8237 -1.2982 Td
(gene)Tj
2.1147 0 Td
(systems,)Tj
3.6 0 Td
(then)Tj
2.0522 0 Td
(we)Tj
1.3436 0 Td
(used)Tj
2.0977 0 Td
(this)Tj
1.7121 0 Td
(knowledge)Tj
4.6204 0 Td
(to)Tj
1.0431 0 Td
(search)Tj
2.8176 0 Td
(the)Tj
1.4967 0 Td
(databases)Tj
4.0762 0 Td
(for)Tj
1.4173 0 Td
(siderophore)Tj
5.1193 0 Td
(systems)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 447.0803 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Sideropho)Tj
4.4716 0 Td
(re)Tj
1.0985 0 Td
(systems)Tj
3.8409 0 Td
(in)Tj
/F7 1 Tf
0.978 0 Td
(Vibrionac)Tj
4.0819 0 Td
(eae)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01918)Tj
4.089 0 Td
(60)Tj
0 g
2.0906 0 Td
(February)Tj
4.1599 0 Td
(14,)Tj
1.5874 0 Td
(2018)Tj
33.1585 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
110 0 obj
<>stream
endstream
endobj
111 0 obj
<>stream
endstream
endobj
112 0 obj
<>stream
endstream
endobj
113 0 obj
<>stream
endstream
endobj
114 0 obj
<>stream
endstream
endobj
115 0 obj
<>stream
endstream
endobj
116 0 obj
<>stream
endstream
endobj
117 0 obj
<>stream
endstream
endobj
118 0 obj
<>stream
endstream
endobj
119 0 obj
<>stream
endstream
endobj
120 0 obj
<>stream
endstream
endobj
121 0 obj
<>stream
endstream
endobj
122 0 obj
<>stream
endstream
endobj
123 0 obj
<>stream
endstream
endobj
124 0 obj
<>stream
endstream
endobj
125 0 obj
<>stream
endstream
endobj
126 0 obj
<>stream
endstream
endobj
127 0 obj
<>stream
endstream
endobj
128 0 obj
<>stream
endstream
endobj
129 0 obj
<>stream
endstream
endobj
130 0 obj
<>stream
endstream
endobj
131 0 obj
<>stream
endstream
endobj
132 0 obj
<>stream
endstream
endobj
133 0 obj
<>stream
endstream
endobj
134 0 obj
<>stream
endstream
endobj
135 0 obj
<>stream
endstream
endobj
136 0 obj
<>stream
endstream
endobj
137 0 obj
<>stream
BT
66.402 0 Td
(20)Tj
ET
Q
endstream
endobj
138 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 142 0 R/Contents 143 0 R/TrimBox[0 0 612 792]>>
endobj
142 0 obj
[144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R 150 0 R 151 0 R 152 0 R 153 0 R 154 0 R 155 0 R 156 0 R 157 0 R 158 0 R]
endobj
144 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.t001)>>
endobj
145 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.t002)>>
endobj
146 0 obj
<>/Border[0 0 0]/Dest(Lpone.0191860.t001)>>
endobj
147 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref053)>>
endobj
148 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref047)>>
endobj
149 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref024)>>
endobj
150 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref009)>>
endobj
151 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref010)>>
endobj
152 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref041)>>
endobj
153 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref037)>>
endobj
154 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref040)>>
endobj
155 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref016)>>
endobj
156 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref051)>>
endobj
157 0 obj
<>/Border[0 0 0]/A 159 0 R>>
endobj
159 0 obj
<>
endobj
158 0 obj
<>/Border[0 0 0]/A 160 0 R>>
endobj
160 0 obj
<>
endobj
143 0 obj
[161 0 R 162 0 R 163 0 R 164 0 R 165 0 R 166 0 R 167 0 R 168 0 R 169 0 R 170 0 R 171 0 R 172 0 R 173 0 R 174 0 R 175 0 R 176 0 R]
endobj
161 0 obj
<>stream
q
0.83 0.64 0.02 0 k
495.4961 250.9228 m
500.2583 250.9228 l
h
f*
520.1008 250.9228 m
524.9764 250.9228 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 443.3952 cm
BT
/F8 1 Tf
1 TL
0.005 Tc
0 0 Td
(in)Tj
1.0544 0 Td
(all)Tj
1.1736 0 Td
(available)Tj
/F13 1 Tf
3.7473 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.4822 0 Td
(genomes,)Tj
4.0649 0 Td
(and)Tj
1.7574 0 Td
(mapped)Tj
3.5093 0 Td
(the)Tj
1.4967 0 Td
(result)Tj
2.5058 0 Td
(onto)Tj
2.1146 0 Td
(a)Tj
/F13 1 Tf
0.6633 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.4822 0 Td
(phyloge-)Tj
-33.0517 -1.2982 Td
(netic)Tj
2.2223 0 Td
(network.)Tj
3.8494 0 Td
(The)Tj
1.8085 0 Td
(evolution)Tj
4.0819 0 Td
(of)Tj
1.0318 0 Td
(individual)Tj
4.3766 0 Td
(siderophore)Tj
5.1251 0 Td
(biosynthesis)Tj
5.21 0 Td
(systems)Tj
3.3619 0 Td
(and)Tj
1.7574 0 Td
(receptors)Tj
-32.8249 -1.3039 Td
(was)Tj
1.7234 0 Td
(next)Tj
1.9956 0 Td
(studied)Tj
3.2144 0 Td
(by)Tj
1.1963 0 Td
(constructing)Tj
5.3687 0 Td
(phylogenetic)Tj
5.4312 0 Td
(trees)Tj
2.143 0 Td
(based)Tj
2.5171 0 Td
(on)Tj
1.2926 0 Td
(amino)Tj
2.846 0 Td
(acids)Tj
2.2734 0 Td
(datasets,)Tj
3.668 0 Td
(and)Tj
1.7574 0 Td
(by)Tj
-35.4271 -1.2983 Td
(comparing)Tj
4.6544 0 Td
(the)Tj
1.4967 0 Td
(resulting)Tj
3.8097 0 Td
(tree)Tj
1.7688 0 Td
(topologies)Tj
4.4107 0 Td
(to)Tj
1.0432 0 Td
(host)Tj
1.9502 0 Td
(trees.)Tj
2.3754 0 Td
(Through)Tj
3.8211 0 Td
(the)Tj
1.4967 0 Td
(presented)Tj
4.1952 0 Td
(work,)Tj
2.5512 0 Td
(we)Tj
1.3436 0 Td
(wish)Tj
-34.9169 -1.2983 Td
(to)Tj
1.0431 0 Td
(broaden)Tj
3.6 0 Td
(the)Tj
1.4967 0 Td
(perspective)Tj
4.8018 0 Td
(and)Tj
1.7575 0 Td
(existing)Tj
3.3845 0 Td
(knowledge)Tj
4.6261 0 Td
(on)Tj
1.2926 0 Td
(siderophore)Tj
5.125 0 Td
(synthesis)Tj
3.9005 0 Td
(and)Tj
1.7575 0 Td
(utilization)Tj
-32.7853 -1.2982 Td
(within)Tj
2.8629 0 Td
(the)Tj
/F13 1 Tf
1.4967 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.4878 0 Td
(family.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 352.0062 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Materials)Tj
4.5071 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
/F14 1 Tf
-6.4961 -1.5023 Td
(Data)Tj
2.2441 0 Td
(retrieval)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 317.0267 cm
BT
/F8 1 Tf
1 TL
0.005 Tc
0 0 Td
(Siderophore)Tj
5.2383 0 Td
(biosynthesis)Tj
5.2101 0 Td
(gene)Tj
2.1146 0 Td
(clusters)Tj
3.3052 0 Td
(and)Tj
1.7575 0 Td
(associated)Tj
4.3483 0 Td
(siderophore)Tj
5.125 0 Td
(receptor)Tj
3.6226 0 Td
(genes)Tj
2.4888 0 Td
(in)Tj
/F13 1 Tf
1.0545 0 Td
[(\n)53()14()11(\r)-9()4()]TJ
-34.2649 -1.3039 Td
[()6()6()7()7()6()]TJ
/F8 1 Tf
2.931 0 Td
(were)Tj
2.1543 0 Td
(identified)Tj
4.1499 0 Td
(by)Tj
1.2018 0 Td
(literature)Tj
3.9685 0 Td
(searches,)Tj
3.8495 0 Td
(and)Tj
1.7574 0 Td
(the)Tj
1.4967 0 Td
(corresponding)Tj
6.1795 0 Td
(protein)Tj
3.2145 0 Td
(sequences)Tj
4.3029 0 Td
(were)Tj
-35.206 -1.2982 Td
(retrieved)Tj
3.8607 0 Td
(from)Tj
2.2394 0 Td
(NCBI's)Tj
3.1691 0 Td
(protein)Tj
3.2201 0 Td
(sequence)Tj
3.9288 0 Td
(databank.)Tj
4.2066 0 Td
(The)Tj
1.8085 0 Td
(literature)Tj
3.9741 0 Td
(search)Tj
2.812 0 Td
(was)Tj
1.7234 0 Td
(done)Tj
2.2677 0 Td
(over)Tj
2.0126 0 Td
(sev-)Tj
-35.223 -1.2983 Td
(eral)Tj
1.7291 0 Td
(months)Tj
3.3392 0 Td
(during)Tj
2.982 0 Td
(fall)Tj
1.4683 0 Td
(2016.)Tj
2.3925 0 Td
(Updated)Tj
3.7473 0 Td
(RefSeq)Tj
3.0104 0 Td
(accession)Tj
4.0535 0 Td
(numbers)Tj
3.8381 0 Td
(for)Tj
1.4173 0 Td
(identified)Tj
4.1443 0 Td
(proteins)Tj
3.5886 0 Td
(with)Tj
-35.7106 -1.3039 Td
(the)Tj
1.4966 0 Td
(`WP')Tj
2.2224 0 Td
(prefix)Tj
2.6022 0 Td
(\(the)Tj
1.8481 0 Td
(`WP')Tj
2.2224 0 Td
(accession)Tj
4.0478 0 Td
(prefix)Tj
2.6079 0 Td
(was)Tj
1.7235 0 Td
(introduced)Tj
4.7338 0 Td
(to)Tj
1.0431 0 Td
(decrease)Tj
3.6794 0 Td
(redundancy)Tj
5.0966 0 Td
(in)Tj
1.0545 0 Td
(RefSeq,)Tj
-34.3783 -1.2983 Td
(and)Tj
1.7574 0 Td
(has)Tj
1.5704 0 Td
(replaced)Tj
3.6567 0 Td
(the)Tj
1.4967 0 Td
(`YP',)Tj
2.1203 0 Td
(`NP')Tj
1.9955 0 Td
(and)Tj
1.7518 0 Td
(`ZP')Tj
1.8596 0 Td
(prefixes\))Tj
3.7587 0 Td
(are)Tj
1.474 0 Td
(presented)Tj
4.1952 0 Td
(in)Tj
1.0545 0 Td
(Tables)Tj
0.83 0.64 0.02 0 k
2.8573 0 Td
(1)Tj
0 g
0.703 0 Td
(and)Tj
0.83 0.64 0.02 0 k
1.7575 0 Td
(2)Tj
0 g
(.)Tj
0.9411 0 Td
(These)Tj
-32.9497 -1.2982 Td
(sequences)Tj
4.2972 0 Td
(were)Tj
2.16 0 Td
(next)Tj
1.9899 0 Td
(used)Tj
2.0977 0 Td
(as)Tj
1.0318 0 Td
(queries)Tj
3.1634 0 Td
(in)Tj
1.0545 0 Td
(BLASTp)Tj
3.6793 0 Td
(searches)Tj
3.617 0 Td
(to)Tj
1.0432 0 Td
(find)Tj
1.8878 0 Td
(homologous)Tj
5.2838 0 Td
(protein)Tj
-31.3056 -1.304 Td
(sequences.)Tj
4.5354 0 Td
(BLASTp)Tj
3.6793 0 Td
(was)Tj
1.7235 0 Td
(run)Tj
1.6951 0 Td
(using)Tj
2.4377 0 Td
(the)Tj
1.4967 0 Td
(non-redundant)Tj
6.497 0 Td
(protein)Tj
3.2145 0 Td
(database)Tj
3.7133 0 Td
(while)Tj
2.4095 0 Td
(restricting)Tj
4.4163 0 Td
(the)Tj
-35.8183 -1.2982 Td
(search)Tj
2.8119 0 Td
(to)Tj
1.0431 0 Td
(the)Tj
/F13 1 Tf
1.4967 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.4822 0 Td
(family)Tj
2.7836 0 Td
(\(NCBI)Tj
2.9253 0 Td
(taxid:)Tj
2.4945 0 Td
(641\).)Tj
2.2564 0 Td
(The)Tj
1.8085 0 Td
(following)Tj
4.0592 0 Td
(criteria)Tj
3.1464 0 Td
(were)Tj
2.16 0 Td
(used)Tj
2.0976 0 Td
(to)Tj
-34.5654 -1.2983 Td
(decide)Tj
2.8629 0 Td
(if)Tj
0.7937 0 Td
(a)Tj
0.6633 0 Td
(siderophore)Tj
5.125 0 Td
(biosynthesis)Tj
5.2101 0 Td
(gene)Tj
2.1203 0 Td
(cluster)Tj
2.931 0 Td
(is)Tj
0.8674 0 Td
(present)Tj
3.2258 0 Td
(in)Tj
1.0545 0 Td
(any)Tj
1.6837 0 Td
(given)Tj
2.4265 0 Td
(species:)Tj
3.2938 0 Td
(\(i\))Tj
1.1906 0 Td
(threshold)Tj
-33.4486 -1.3039 Td
(values)Tj
2.7212 0 Td
(from)Tj
2.2393 0 Td
(BLASTp)Tj
3.6794 0 Td
(were)Tj
2.16 0 Td
(set)Tj
1.3323 0 Td
(to)Tj
/F15 1 Tf
0 Tc
1.0431 0 Td
()Tj
/F8 1 Tf
0.005 Tc
(80%)Tj
2.7269 0 Td
(coverage)Tj
3.7927 0 Td
(and)Tj
/F15 1 Tf
0 Tc
1.7575 0 Td
()Tj
/F8 1 Tf
0.005 Tc
(50%)Tj
2.7269 0 Td
(identity,)Tj
3.6113 0 Td
(\(ii\))Tj
1.4684 0 Td
(all)Tj
1.1735 0 Td
(proteins)Tj
3.5887 0 Td
(associ-)Tj
-34.0212 -1.2983 Td
(ated)Tj
1.9388 0 Td
(with)Tj
2.0353 0 Td
(a)Tj
0.6576 0 Td
(siderophore)Tj
5.125 0 Td
(gene)Tj
2.1203 0 Td
(cluster)Tj
2.931 0 Td
(must)Tj
2.2621 0 Td
(be)Tj
1.1678 0 Td
(present)Tj
3.2259 0 Td
(in)Tj
1.0544 0 Td
(the)Tj
1.4967 0 Td
(same)Tj
2.2961 0 Td
(species,)Tj
3.2938 0 Td
(\(iii\))Tj
1.7461 0 Td
(pseudogenes)Tj
-31.3509 -1.2982 Td
(were)Tj
2.1599 0 Td
(rejected,)Tj
3.6737 0 Td
(and)Tj
1.7575 0 Td
(\(iv\))Tj
1.6554 0 Td
(BLASTp)Tj
3.6794 0 Td
(hits)Tj
1.7121 0 Td
(labelled)Tj
3.3448 0 Td
(low)Tj
2.0863 0 Td
(quality)Tj
3.0161 0 Td
(protein)Tj
3.6169 0 Td
(in)Tj
1.0545 0 Td
(the)Tj
1.4967 0 Td
(databases)Tj
4.0819 0 Td
(were)Tj
-33.3352 -1.2983 Td
(excluded.)Tj
4.0875 0 Td
(Within-species)Tj
6.3495 0 Td
(variations)Tj
4.252 0 Td
(were)Tj
2.16 0 Td
(not)Tj
1.5987 0 Td
(considered)Tj
4.6942 0 Td
(because)Tj
3.3788 0 Td
(it)Tj
0.8051 0 Td
(would)Tj
2.7609 0 Td
(require)Tj
3.1748 0 Td
(extensive)Tj
-33.2615 -1.3039 Td
(manual)Tj
3.2824 0 Td
(curation)Tj
3.6681 0 Td
(of)Tj
1.0318 0 Td
(a)Tj
0.6633 0 Td
(huge)Tj
2.1996 0 Td
(number)Tj
3.4753 0 Td
(of)Tj
1.0318 0 Td
(blast)Tj
2.109 0 Td
(hits)Tj
1.7121 0 Td
(and)Tj
1.7574 0 Td
(database)Tj
3.7134 0 Td
(entries,)Tj
3.2088 0 Td
(which)Tj
2.6929 0 Td
(was)Tj
1.7291 0 Td
(not)Tj
1.5988 0 Td
(feasible)Tj
-33.8738 -1.2983 Td
(to)Tj
1.0374 0 Td
(do)Tj
1.2643 0 Td
(as)Tj
1.0261 0 Td
(part)Tj
1.8709 0 Td
(of)Tj
1.0261 0 Td
(this)Tj
1.7008 0 Td
(study.)Tj
2.6645 0 Td
(Also,)Tj
2.2791 0 Td
(some)Tj
2.3584 0 Td
(of)Tj
1.0261 0 Td
(the)Tj
1.491 0 Td
(siderophore)Tj
5.1137 0 Td
(pathways)Tj
3.9968 0 Td
(may)Tj
1.9502 0 Td
(share)Tj
2.3755 0 Td
(parts)Tj
2.2393 0 Td
(of)Tj
1.0261 0 Td
(the)Tj
1.4911 0 Td
(bio-)Tj
-35.9374 -1.2982 Td
(synthesis)Tj
3.9004 0 Td
(steps)Tj
2.228 0 Td
(e.g.,)Tj
1.8312 0 Td
(in)Tj
1.0545 0 Td
(the)Tj
1.4966 0 Td
(proposed)Tj
4.0196 0 Td
(pathways)Tj
4.0024 0 Td
(of)Tj
1.0375 0 Td
(anguibactin,)Tj
5.2724 0 Td
(vanchrobaction,)Tj
6.8315 0 Td
(vibriobactin)Tj
-31.6741 -1.304 Td
(and)Tj
1.7574 0 Td
(enterobactin)Tj
5.3745 0 Td
(synthesis,)Tj
4.1385 0 Td
(all)Tj
1.1736 0 Td
(involve)Tj
3.1861 0 Td
(synthesis)Tj
3.9061 0 Td
(of)Tj
1.0318 0 Td
(DHBA,)Tj
3.2598 0 Td
(later)Tj
2.0353 0 Td
(the)Tj
1.4967 0 Td
(four)Tj
1.9502 0 Td
(pathways)Tj
4.0025 0 Td
(split)Tj
1.9559 0 Td
(into)Tj
-35.2684 -1.2982 Td
(unique)Tj
3.0727 0 Td
(steps.)Tj
2.4604 0 Td
(Siderophore)Tj
5.2384 0 Td
(synthesis)Tj
3.9062 0 Td
(pathways)Tj
4.0024 0 Td
(may)Tj
1.9559 0 Td
(therefore)Tj
3.9345 0 Td
(use)Tj
1.559 0 Td
(common)Tj
3.9005 0 Td
(enzymes,)Tj
3.9571 0 Td
(or)Tj
1.1169 0 Td
(they)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 703.8893 m
576 703.8893 l
576 703.3893 l
36 703.3893 l
f*
99.157 703.3893 m
99.157 690.8893 l
98.657 690.8893 l
98.657 703.3893 l
f*
98.657 690.8893 m
36 690.8893 l
36 691.3894 l
98.657 691.3894 l
f*
181.1327 703.3893 m
181.1327 690.8893 l
180.6327 690.8893 l
180.6327 703.3893 l
f*
180.6327 690.8893 m
99.157 690.8893 l
99.157 691.3894 l
180.6327 691.3894 l
f*
551.2263 703.3893 m
551.2263 690.8893 l
550.7263 690.8893 l
550.7263 703.3893 l
f*
550.7263 690.8893 m
181.1327 690.8893 l
181.1327 691.3894 l
550.7263 691.3894 l
f*
576 690.8893 m
551.2263 690.8893 l
551.2263 691.3894 l
576 691.3894 l
f*
99.157 690.8893 m
99.157 678.3894 l
98.657 678.3894 l
98.657 690.8893 l
f*
98.657 678.3894 m
36 678.3894 l
36 678.8894 l
98.657 678.8894 l
f*
181.1327 690.8893 m
181.1327 678.3894 l
180.6327 678.3894 l
180.6327 690.8893 l
f*
180.6327 678.3894 m
99.157 678.3894 l
99.157 678.8894 l
180.6327 678.8894 l
f*
551.2263 690.8893 m
551.2263 678.3894 l
550.7263 678.3894 l
550.7263 690.8893 l
f*
550.7263 678.3894 m
181.1327 678.3894 l
181.1327 678.8894 l
550.7263 678.8894 l
f*
576 678.3894 m
551.2263 678.3894 l
551.2263 678.8894 l
576 678.8894 l
f*
99.157 678.3894 m
99.157 665.8894 l
98.657 665.8894 l
98.657 678.3894 l
f*
98.657 665.8894 m
36 665.8894 l
36 666.3895 l
98.657 666.3895 l
f*
181.1327 678.3894 m
181.1327 665.8894 l
180.6327 665.8894 l
180.6327 678.3894 l
f*
180.6327 665.8894 m
99.157 665.8894 l
99.157 666.3895 l
180.6327 666.3895 l
f*
551.2263 678.3894 m
551.2263 665.8894 l
550.7263 665.8894 l
550.7263 678.3894 l
f*
550.7263 665.8894 m
181.1327 665.8894 l
181.1327 666.3895 l
550.7263 666.3895 l
f*
576 665.8894 m
551.2263 665.8894 l
551.2263 666.3895 l
576 666.3895 l
f*
99.157 665.8894 m
99.157 643.8895 l
98.657 643.8895 l
98.657 665.8894 l
f*
98.657 643.8895 m
36 643.8895 l
36 644.3895 l
98.657 644.3895 l
f*
181.1327 665.8894 m
181.1327 643.8895 l
180.6327 643.8895 l
180.6327 665.8894 l
f*
180.6327 643.8895 m
99.157 643.8895 l
99.157 644.3895 l
180.6327 644.3895 l
f*
551.2263 665.8894 m
551.2263 643.8895 l
550.7263 643.8895 l
550.7263 665.8894 l
f*
550.7263 643.8895 m
181.1327 643.8895 l
181.1327 644.3895 l
550.7263 644.3895 l
f*
576 643.8895 m
551.2263 643.8895 l
551.2263 644.3895 l
576 644.3895 l
f*
99.157 643.8895 m
99.157 621.8895 l
98.657 621.8895 l
98.657 643.8895 l
f*
98.657 621.8895 m
36 621.8895 l
36 622.3895 l
98.657 622.3895 l
f*
181.1327 643.8895 m
181.1327 621.8895 l
180.6327 621.8895 l
180.6327 643.8895 l
f*
180.6327 621.8895 m
99.157 621.8895 l
99.157 622.3895 l
180.6327 622.3895 l
f*
551.2263 643.8895 m
551.2263 621.8895 l
550.7263 621.8895 l
550.7263 643.8895 l
f*
550.7263 621.8895 m
181.1327 621.8895 l
181.1327 622.3895 l
550.7263 622.3895 l
f*
576 621.8895 m
551.2263 621.8895 l
551.2263 622.3895 l
576 622.3895 l
f*
99.157 621.8895 m
99.157 599.8895 l
98.657 599.8895 l
98.657 621.8895 l
f*
98.657 599.8895 m
36 599.8895 l
36 600.3896 l
98.657 600.3896 l
f*
181.1327 621.8895 m
181.1327 599.8895 l
180.6327 599.8895 l
180.6327 621.8895 l
f*
180.6327 599.8895 m
99.157 599.8895 l
99.157 600.3896 l
180.6327 600.3896 l
f*
551.2263 621.8895 m
551.2263 599.8895 l
550.7263 599.8895 l
550.7263 621.8895 l
f*
550.7263 599.8895 m
181.1327 599.8895 l
181.1327 600.3896 l
550.7263 600.3896 l
f*
576 599.8895 m
551.2263 599.8895 l
551.2263 600.3896 l
576 600.3896 l
f*
99.157 599.8895 m
99.157 577.8896 l
98.657 577.8896 l
98.657 599.8895 l
f*
98.657 577.8896 m
36 577.8896 l
36 578.3896 l
98.657 578.3896 l
f*
181.1327 599.8895 m
181.1327 577.8896 l
180.6327 577.8896 l
180.6327 599.8895 l
f*
180.6327 577.8896 m
99.157 577.8896 l
99.157 578.3896 l
180.6327 578.3896 l
f*
551.2263 599.8895 m
551.2263 577.8896 l
550.7263 577.8896 l
550.7263 599.8895 l
f*
550.7263 577.8896 m
181.1327 577.8896 l
181.1327 578.3896 l
550.7263 578.3896 l
f*
576 577.8896 m
551.2263 577.8896 l
551.2263 578.3896 l
576 578.3896 l
f*
99.157 577.8896 m
99.157 546.3896 l
98.657 546.3896 l
98.657 577.8896 l
f*
98.657 546.3896 m
36 546.3896 l
36 546.8896 l
98.657 546.8896 l
f*
181.1327 577.8896 m
181.1327 546.3896 l
180.6327 546.3896 l
180.6327 577.8896 l
f*
180.6327 546.3896 m
99.157 546.3896 l
99.157 546.8896 l
180.6327 546.8896 l
f*
551.2263 577.8896 m
551.2263 546.3896 l
550.7263 546.3896 l
550.7263 577.8896 l
f*
550.7263 546.3896 m
181.1327 546.3896 l
181.1327 546.8896 l
550.7263 546.8896 l
f*
576 546.3896 m
551.2263 546.3896 l
551.2263 546.8896 l
576 546.8896 l
f*
99.157 546.3896 m
99.157 514.8896 l
98.657 514.8896 l
98.657 546.3896 l
f*
98.657 514.8896 m
36 514.8896 l
36 515.3896 l
98.657 515.3896 l
f*
181.1327 546.3896 m
181.1327 514.8896 l
180.6327 514.8896 l
180.6327 546.3896 l
f*
180.6327 514.8896 m
99.157 514.8896 l
99.157 515.3896 l
180.6327 515.3896 l
f*
551.2263 546.3896 m
551.2263 514.8896 l
550.7263 514.8896 l
550.7263 546.3896 l
f*
550.7263 514.8896 m
181.1327 514.8896 l
181.1327 515.3896 l
550.7263 515.3896 l
f*
576 514.8896 m
551.2263 514.8896 l
551.2263 515.3896 l
576 515.3896 l
f*
99.157 514.8896 m
99.157 492.8896 l
98.657 492.8896 l
98.657 514.8896 l
f*
98.657 492.8896 m
36 492.8896 l
36 493.3896 l
98.657 493.3896 l
f*
181.1327 514.8896 m
181.1327 492.8896 l
180.6327 492.8896 l
180.6327 514.8896 l
f*
180.6327 492.8896 m
99.157 492.8896 l
99.157 493.3896 l
180.6327 493.3896 l
f*
551.2263 514.8896 m
551.2263 492.8896 l
550.7263 492.8896 l
550.7263 514.8896 l
f*
550.7263 492.8896 m
181.1327 492.8896 l
181.1327 493.3896 l
550.7263 493.3896 l
f*
576 492.8896 m
551.2263 492.8896 l
551.2263 493.3896 l
576 493.3896 l
f*
0.83 0.64 0.02 0 k
556.9512 680.315 m
564.6047 680.315 l
h
f*
556.9512 667.7858 m
564.6047 667.7858 l
h
f*
556.9512 655.3134 m
564.6047 655.3134 l
h
f*
556.9512 633.3165 m
560.8063 633.3165 l
h
f*
562.6205 633.3165 m
570.274 633.3165 l
h
f*
556.9512 611.3197 m
564.6047 611.3197 l
h
f*
556.9512 589.3228 m
564.6047 589.3228 l
h
f*
556.9512 567.326 m
564.6047 567.326 l
h
f*
556.9512 535.8047 m
564.6047 535.8047 l
h
f*
556.9512 504.3402 m
564.6047 504.3402 l
h
f*
36 479.7921 m
186.7465 479.7921 l
h
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F14 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(1.)Tj
1.1763 0 Td
(RefSeq)Tj
3.0757 0 Td
(accession)Tj
4.0748 0 Td
(number)Tj
3.2882 0 Td
(s)Tj
0.6024 0 Td
(of)Tj
1.063 0 Td
(known)Tj
/F16 1 Tf
3.026 0 Td
[()48()12()4()-12()-1()4()5()5()3( )]TJ
4.9394 0 Td
[( )]TJ
/F14 1 Tf
0.6307 0 Td
(siderophore)Tj
5.2158 0 Td
(biosynt)Tj
3.0543 0 Td
(hetic)Tj
2.2394 0 Td
(proteins.)Tj
0 Tc
-34.9372 -1.8567 Td
(Siderophore)Tj
8.1425 0 Td
(Organism)Tj
10.2474 0 Td
(Siderophore)Tj
5.3929 0 Td
(biosynthes)Tj
4.4646 0 Td
(is)Tj
0.9071 0 Td
(protein)Tj
3.3307 0 Td
(accession)Tj
4.1245 0 Td
(numbers)Tj
28.0419 0 Td
(Ref)Tj
/F8 1 Tf
-64.6516 -1.559 Td
(Aerobacti)Tj
3.9331 0 Td
(n)Tj
/F13 1 Tf
4.337 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1197 0 Td
[()18()12()18()4()1()-4()]TJ
/F8 1 Tf
9.1276 0 Td
(IucA\(WP_0)Tj
4.826 0 Td
(00554936.1\))Tj
5.1024 0 Td
(IucB\(WP_)Tj
4.245 0 Td
(000033134.1)Tj
5.0031 0 Td
(\))Tj
0.5741 0 Td
(IucC\(WP_00)Tj
5.2866 0 Td
(0372426.1)Tj
4.0465 0 Td
(\))Tj
0.574 0 Td
(IucD\(WP_00)Tj
5.3576 0 Td
(0401386.1\))Tj
11.2465 0 Td
([)Tj
0.83 0.64 0.02 0 k
(53)Tj
0 g
(])Tj
-64.7792 -1.5662 Td
(Bisucaber)Tj
3.9118 0 Td
(in)Tj
/F13 1 Tf
4.3583 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1126 0 Td
[()-3()11()12()6()11()18()4()1()4()]TJ
4.2449 0 Td
[()]TJ
/F8 1 Tf
4.8898 0 Td
(BibA\(WP)Tj
3.9119 0 Td
(_012549025)Tj
4.7976 0 Td
(.1\))Tj
1.2827 0 Td
(BibB\(W)Tj
3.2457 0 Td
(P_012549026)Tj
5.3575 0 Td
(.1\))Tj
1.2827 0 Td
(BibC\(WP)Tj
3.8906 0 Td
(_012549027)Tj
4.7977 0 Td
(.1\))Tj
17.6954 0 Td
([)Tj
0.83 0.64 0.02 0 k
(47)Tj
0 g
(])Tj
-64.7792 -1.559 Td
(Vibrioferr)Tj
4.089 0 Td
(in)Tj
/F13 1 Tf
4.1811 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1197 0 Td
[( )4()16(\r)20()11()6()6()2()6()10()15()]TJ
5.1307 0 Td
[()7()4()1()-4()]TJ
/F8 1 Tf
3.9969 0 Td
(PvsA\(WP)Tj
3.9331 0 Td
(_015313675)Tj
4.7977 0 Td
(.1\))Tj
1.2827 0 Td
(PvsB\(W)Tj
3.2669 0 Td
(P_0153136)Tj
4.4009 0 Td
(76.1\))Tj
2.2393 0 Td
(PvsC\(WP)Tj
3.9119 0 Td
(_015313677)Tj
4.7977 0 Td
(.1\))Tj
1.2756 0 Td
(PvsD\(WP_01)Tj
5.4425 0 Td
(5313678.1\))Tj
4.6276 0 Td
(PvsE)Tj
-39.9759 -1.1906 Td
(\(WP_01531)Tj
4.7552 0 Td
(3679.1\))Tj
41.5066 1.1906 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(])Tj
-64.7792 -2.7497 Td
(Vibriobactin)Tj
/F13 1 Tf
8.2701 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1197 0 Td
[()13()6()10()4()2(\r)20()6()]TJ
/F8 1 Tf
9.1276 0 Td
(VibA)Tj
2.3882 0 Td
(\(WP_00065)Tj
4.7552 0 Td
(4285.1\))Tj
3.189 0 Td
(VibB)Tj
2.289 0 Td
(\(WP_00099)Tj
4.7551 0 Td
(7093.1\))Tj
3.189 0 Td
(VibC\(W)Tj
3.4442 0 Td
(P_000245175)Tj
5.3575 0 Td
(.1\))Tj
1.2827 0 Td
(VibD\(WP_)Tj
4.578 0 Td
(000874996.1)Tj
5.0031 0 Td
(\))Tj
0.5741 0 Td
(VibE)Tj
-40.8051 -1.1905 Td
(\(WP_00020)Tj
4.7552 0 Td
(5544.1\))Tj
3.189 0 Td
(VibF)Tj
2.2323 0 Td
(\(WP_00052)Tj
4.7551 0 Td
(3394.1\))Tj
3.189 0 Td
(VibH\(WP_0)Tj
5.0883 0 Td
(01880577.1\))Tj
23.0529 1.1905 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(])Tj
-64.7792 -2.7496 Td
(Vanchroba)Tj
4.4646 0 Td
(ctin)Tj
/F13 1 Tf
3.8055 0 Td
[(\n)53()14()11(\r)-9()4()]TJ
2.7425 0 Td
[()16()13( )-8()12()4()4()4()16(\r)-9()]TJ
4.089 0 Td
[()]TJ
/F8 1 Tf
3.4158 0 Td
(DapH\(WP_)Tj
4.826 0 Td
(011154675.1)Tj
5.0032 0 Td
(\))Tj
0.5741 0 Td
(VabA\(WP_0)Tj
5.1732 0 Td
(64624836.)Tj
4.0465 0 Td
(1\))Tj
1.0559 0 Td
(VabB\(WP)Tj
4.089 0 Td
(_06462483)Tj
4.3158 0 Td
(1.1\))Tj
1.7575 0 Td
(VabC\(WP_0)Tj
5.152 0 Td
(43004165.1\))Tj
5.1024 0 Td
(VabE)Tj
-41.0956 -1.1906 Td
(\(WP_01928)Tj
4.7552 0 Td
(1788.1\))Tj
3.189 0 Td
(VabF)Tj
2.4024 0 Td
(\(WP_0192)Tj
4.2732 0 Td
(81791.1\))Tj
3.6709 0 Td
(VabH)Tj
2.6363 0 Td
(\(WP_01928)Tj
4.7551 0 Td
(1793.1\))Tj
20.5797 1.1906 Td
([)Tj
0.83 0.64 0.02 0 k
(41)Tj
0 g
(])Tj
-64.7792 -2.7496 Td
(Piscibactin)Tj
/F13 1 Tf
8.2701 0 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0063 0 Td
[()4()16()-3()15()4()6()]TJ
3.8481 0 Td
[()10()14()7()10( )]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
-4.8544 -1.1906 Td
[( )11()-4()-3()1()4()1()4()4()]TJ
/F8 1 Tf
10.2473 1.1906 Td
(DapH)Tj
2.693 0 Td
(\(AKQ52)Tj
3.4016 0 Td
(526.1\))Tj
2.7141 0 Td
(Irp1\(AKQ)Tj
4.1599 0 Td
(52532.1\))Tj
3.6709 0 Td
(Irp2\(AKQ)Tj
4.1599 0 Td
(52531.1\))Tj
3.6709 0 Td
(Irp3\(AKQ)Tj
4.1599 0 Td
(52533.1\))Tj
3.6709 0 Td
(Irp4\(AKQ)Tj
4.1598 0 Td
(52534.1\))Tj
3.6709 0 Td
(Irp5)Tj
-40.1318 -1.1906 Td
(\(AKQ52)Tj
3.4016 0 Td
(536.1\))Tj
42.8602 1.1906 Td
([)Tj
0.83 0.64 0.02 0 k
(37)Tj
0 g
(])Tj
-64.7792 -2.7497 Td
(Anguiba)Tj
3.4441 0 Td
(ctin)Tj
/F13 1 Tf
4.826 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1197 0 Td
[()16()13( )-8()12()4()4()4()16(\r)-9()12()]TJ
/F8 1 Tf
9.1276 0 Td
(AngA\(WP_)Tj
4.7552 0 Td
(013857267.1)Tj
5.0032 0 Td
(\))Tj
0.574 0 Td
(AngB\(WP_)Tj
4.6488 0 Td
(013857270.1\))Tj
5.5843 0 Td
(AngC\(W)Tj
3.6709 0 Td
(P_0430041)Tj
4.4009 0 Td
(65.1\))Tj
2.2393 0 Td
(AngE\(W)Tj
3.5788 0 Td
(P_0138572)Tj
4.4008 0 Td
(69.1\))Tj
2.2394 0 Td
(AngB/G)Tj
-41.0956 -1.1905 Td
(\(WP_01115)Tj
4.7552 0 Td
(4672.1\))Tj
3.189 0 Td
(AngM\(WP)Tj
4.4646 0 Td
(_011154633)Tj
4.7977 0 Td
(.1\))Tj
1.2756 0 Td
(AngT\(WP_01)Tj
5.6409 0 Td
(1154640.1\))Tj
4.6206 0 Td
(AngH\(WP_01)Tj
5.7968 0 Td
(1154645.1)Tj
4.0465 0 Td
(\))Tj
0.5741 0 Td
(AngR)Tj
-39.161 -1.1835 Td
(\(WP_01115)Tj
4.7552 0 Td
(4639.1\))Tj
3.189 0 Td
(AngN\(WP)Tj
4.3087 0 Td
(_011154642)Tj
4.7976 0 Td
(.1\))Tj
1.2756 0 Td
(AngU\(WP_0)Tj
5.2867 0 Td
(11154641.1\))Tj
5.1024 0 Td
(AngD\(WP)Tj
4.3087 0 Td
(_011154670)Tj
4.7977 0 Td
(.1\))Tj
8.4402 2.374 Td
([)Tj
0.83 0.64 0.02 0 k
(40)Tj
0 g
(])Tj
-64.7792 -3.9401 Td
(Vulnibactin)Tj
/F13 1 Tf
8.2701 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1197 0 Td
[()-13()4()12()18()12()-8()4()1()-4()]TJ
/F8 1 Tf
9.1276 0 Td
(VV2_0830\()Tj
4.6205 0 Td
(WP_0110)Tj
3.9331 0 Td
(81748.1\))Tj
3.6709 0 Td
(VV2_0831)Tj
4.2733 0 Td
(\(AAO07755.1)Tj
5.5559 0 Td
(\))Tj
0.5741 0 Td
(VV2_0834\()Tj
4.6205 0 Td
(WP_0110)Tj
3.9331 0 Td
(81751.1\))Tj
3.6709 0 Td
(VV2_0835)Tj
-34.8523 -1.1835 Td
(\(WP_01108)Tj
4.7552 0 Td
(1752.1\))Tj
3.189 0 Td
(VV2_0836\()Tj
4.6205 0 Td
(WP_0110)Tj
3.9331 0 Td
(81753.1\))Tj
3.6709 0 Td
(VV2_0838/)Tj
4.6063 0 Td
(VenB\(WP_)Tj
4.6205 0 Td
(011081755.1\))Tj
5.5772 0 Td
(VV2_0839)Tj
-34.9727 -1.1906 Td
(\(WP_01108)Tj
4.7552 0 Td
(1756.1\))Tj
3.189 0 Td
(VV2_0840\()Tj
4.6205 0 Td
(WP_0110)Tj
3.9331 0 Td
(81757.1\))Tj
3.6709 0 Td
(VV2_0844\()Tj
4.6205 0 Td
(AAO0776)Tj
4.0252 0 Td
(7.2\))Tj
17.4474 2.3741 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(])Tj
-64.7792 -3.9331 Td
(Amphi-)Tj
0 -1.1906 Td
(enterobac)Tj
3.9543 0 Td
(tin)Tj
/F13 1 Tf
4.3158 1.1906 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1197 0 Td
[()7()16()15( )13()4()15()4()12()12()]TJ
/F8 1 Tf
9.1276 0 Td
(AebG)Tj
2.5654 0 Td
(\(WP_01212)Tj
4.7551 0 Td
(7281.1\))Tj
3.1891 0 Td
(AebA\(WP_0)Tj
5.152 0 Td
(41853223.)Tj
4.0464 0 Td
(1\))Tj
1.056 0 Td
(AebC\(WP_)Tj
4.6488 0 Td
(012127292.1)Tj
5.0032 0 Td
(\))Tj
0.574 0 Td
(AebE\(WP_)Tj
4.5568 0 Td
(012127293.1\))Tj
5.5772 0 Td
(AebB)Tj
-41.124 -1.1906 Td
(\(WP_01212)Tj
4.7552 0 Td
(7294.1\))Tj
3.189 0 Td
(AebF\(WP_)Tj
4.5142 0 Td
(041853220.1\))Tj
33.8034 1.1906 Td
([)Tj
0.83 0.64 0.02 0 k
(51)Tj
0 g
(])Tj
0.83 0.64 0.02 0 k
/F10 1 Tf
-0.025 Tc
-64.7792 -3.0686 Td
(https://do)Tj
3.5575 0 Td
(i.org/10.1371/j)Tj
5.4425 0 Td
(ournal.pone)Tj
4.4079 0 Td
(.0191860.t001)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 447.0803 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Sideropho)Tj
4.4716 0 Td
(re)Tj
1.0985 0 Td
(systems)Tj
3.8409 0 Td
(in)Tj
/F7 1 Tf
0.978 0 Td
(Vibrionac)Tj
4.0819 0 Td
(eae)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01918)Tj
4.089 0 Td
(60)Tj
0 g
2.0906 0 Td
(February)Tj
4.1599 0 Td
(14,)Tj
1.5874 0 Td
(2018)Tj
33.1585 0 Td
(4)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
162 0 obj
<>stream
endstream
endobj
163 0 obj
<>stream
endstream
endobj
164 0 obj
<>stream
endstream
endobj
165 0 obj
<>stream
endstream
endobj
166 0 obj
<>stream
endstream
endobj
167 0 obj
<>stream
endstream
endobj
168 0 obj
<>stream
endstream
endobj
169 0 obj
<>stream
endstream
endobj
170 0 obj
<>stream
endstream
endobj
171 0 obj
<>stream
endstream
endobj
172 0 obj
<>stream
endstream
endobj
173 0 obj
<>stream
endstream
endobj
174 0 obj
<>stream
endstream
endobj
175 0 obj
<>stream
endstream
endobj
176 0 obj
<>stream
BT
66.402 0 Td
(20)Tj
ET
Q
endstream
endobj
177 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 178 0 R/Contents 179 0 R/TrimBox[0 0 612 792]>>
endobj
178 0 obj
[180 0 R 181 0 R 182 0 R 183 0 R 184 0 R 185 0 R 186 0 R 187 0 R 188 0 R 189 0 R 190 0 R 191 0 R 192 0 R 193 0 R 194 0 R 195 0 R 196 0 R 197 0 R 198 0 R 199 0 R 200 0 R 201 0 R 202 0 R 203 0 R]
endobj
180 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref008)>>
endobj
181 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref056)>>
endobj
182 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.s001)>>
endobj
183 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.s002)>>
endobj
184 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref057)>>
endobj
185 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref056)>>
endobj
186 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref058)>>
endobj
187 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref059)>>
endobj
188 0 obj
<>/Border[0 0 0]/Dest(Lpone.0191860.t002)>>
endobj
189 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref053)>>
endobj
190 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref047)>>
endobj
191 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref025)>>
endobj
192 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref027)>>
endobj
193 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref011)>>
endobj
194 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref042)>>
endobj
195 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref054)>>
endobj
196 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref013)>>
endobj
197 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref013)>>
endobj
198 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref017)>>
endobj
199 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref014)>>
endobj
200 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref055)>>
endobj
201 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref037)>>
endobj
202 0 obj
<>/Border[0 0 0]/A 204 0 R>>
endobj
204 0 obj
<>
endobj
203 0 obj
<>/Border[0 0 0]/A 205 0 R>>
endobj
205 0 obj
<>
endobj
179 0 obj
[206 0 R 207 0 R 208 0 R 209 0 R 210 0 R 211 0 R 212 0 R 213 0 R 214 0 R 215 0 R 216 0 R 217 0 R 218 0 R 219 0 R 220 0 R 221 0 R 222 0 R 223 0 R 224 0 R 225 0 R 226 0 R 227 0 R 228 0 R]
endobj
206 0 obj
<>stream
q
0.83 0.64 0.02 0 k
475.7669 388.9134 m
480.5291 388.9134 l
h
f*
538.6961 388.9134 m
548.1638 388.9134 l
h
f*
373.5496 284.8819 m
383.074 284.8819 l
h
f*
402.5197 284.8819 m
412.1008 284.8819 l
h
f*
243.0425 224.9008 m
252.5102 224.9008 l
h
f*
553.6063 224.9008 m
563.1307 224.9008 l
h
f*
510.2362 211.9181 m
519.7606 211.9181 l
h
f*
355.9181 107.9433 m
365.3858 107.9433 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 462.9543 cm
BT
/F8 1 Tf
1 TL
0.005 Tc
0 0 Td
(may)Tj
1.9558 0 Td
(encode)Tj
3.1238 0 Td
(redundant)Tj
4.5127 0 Td
(enzymes.)Tj
3.9572 0 Td
(Such)Tj
2.211 0 Td
(overlapping)Tj
5.074 0 Td
(and)Tj
1.7574 0 Td
(redundancies)Tj
5.709 0 Td
(of)Tj
1.0318 0 Td
(pathways)Tj
4.0081 0 Td
(were)Tj
2.1544 0 Td
(not)Tj
-35.4952 -1.2982 Td
(specifically)Tj
4.6771 0 Td
(considered)Tj
4.6941 0 Td
(in)Tj
1.0545 0 Td
(this)Tj
1.7065 0 Td
(work.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 419.9811 cm
BT
/F14 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Mapping)Tj
3.9921 0 Td
(of)Tj
1.0677 0 Td
(siderophore)Tj
5.2442 0 Td
(systems)Tj
3.4441 0 Td
(onto)Tj
2.1496 0 Td
(a)Tj
/F16 1 Tf
0.6851 0 Td
[()48()12()4()-12()-1()4()5()5()3( )5( )]TJ
/F14 1 Tf
5.6032 0 Td
(phylogenetic)Tj
5.5417 0 Td
(network)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 402.9732 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(A)Tj
/F13 1 Tf
0.9014 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.3744 0 Td
(host)Tj
1.9162 0 Td
(phylogeny)Tj
4.3654 0 Td
(was)Tj
1.7007 0 Td
(inferred)Tj
3.4413 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2755 0 Td
(sequence)Tj
3.8551 0 Td
(alignments)Tj
4.6318 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(genes)Tj
/F13 1 Tf
2.4378 0 Td
[()-4(-)]TJ
/F8 1 Tf
(,)Tj
/F13 1 Tf
-34.8602 -1.2982 Td
[( )2()12( )]TJ
/F8 1 Tf
(,)Tj
/F13 1 Tf
1.8198 0 Td
[( )-21()-13(\r)]TJ
/F8 1 Tf
(,)Tj
/F13 1 Tf
2.2223 0 Td
[()18(\r)20()]TJ
/F8 1 Tf
(,)Tj
/F13 1 Tf
2.5455 0 Td
[( )12()-13(\r)]TJ
/F8 1 Tf
(,)Tj
/F13 1 Tf
2.4548 0 Td
[(\r)20()7()]TJ
/F8 1 Tf
(,)Tj
/F13 1 Tf
2.2224 0 Td
[(\r)-20( )4()]TJ
/F8 1 Tf
2.1713 0 Td
(and)Tj
/F13 1 Tf
1.7291 0 Td
[()11()11( )]TJ
/F8 1 Tf
(,)Tj
2.3414 0 Td
(provided)Tj
3.8154 0 Td
(by)Tj
1.1792 0 Td
(Dr.)Tj
1.5534 0 Td
(Sawabe)Tj
3.1805 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
1.5987 0 Td
(SplitsTree4)Tj
4.6941 0 Td
([)Tj
0.83 0.64 0.02 0 k
(56)Tj
0 g
(])Tj
1.8482 0 Td
(was)Tj
-35.3761 -1.3039 Td
(used)Tj
2.0579 0 Td
(to)Tj
1.0261 0 Td
(concatenate)Tj
4.9833 0 Td
(the)Tj
1.4683 0 Td
(sequences)Tj
4.218 0 Td
(to)Tj
1.0261 0 Td
(construct)Tj
3.9798 0 Td
(a)Tj
0.652 0 Td
(multi)Tj
2.3811 0 Td
(locus)Tj
2.2847 0 Td
(sequence)Tj
3.8607 0 Td
(alignment)Tj
4.269 0 Td
(\(MLSA\),)Tj
3.719 0 Td
(and)Tj
-35.926 -1.2983 Td
(to)Tj
1.0261 0 Td
(generate)Tj
3.6056 0 Td
(an)Tj
1.2019 0 Td
(unrooted)Tj
3.9345 0 Td
(phylogenetic)Tj
5.3177 0 Td
(network.)Tj
3.7758 0 Td
(Settings)Tj
3.3618 0 Td
(were)Tj
2.1203 0 Td
(set)Tj
1.304 0 Td
(to)Tj
1.0261 0 Td
(`NeighbourNet')Tj
6.4459 0 Td
(method)Tj
-33.1197 -1.2983 Td
(with)Tj
1.9955 0 Td
(`uncorrected)Tj
5.2894 0 Td
(P')Tj
0.9978 0 Td
(distance.)Tj
3.7304 0 Td
(Presence/absence)Tj
7.2 0 Td
(of)Tj
1.0148 0 Td
(siderophore)Tj
5.0286 0 Td
(biosynthesis)Tj
5.1023 0 Td
(and)Tj
1.7291 0 Td
(receptor)Tj
-32.0879 -1.2982 Td
(genes)Tj
2.4377 0 Td
(were)Tj
2.126 0 Td
(mapped)Tj
3.4582 0 Td
(onto)Tj
2.0807 0 Td
(the)Tj
1.4683 0 Td
(phylogenetic)Tj
5.3234 0 Td
(network.)Tj
3.7758 0 Td
(Only)Tj
2.2166 0 Td
(complete)Tj
3.8778 0 Td
(siderophore)Tj
5.023 0 Td
(biosynthesis)Tj
-31.7875 -1.3039 Td
(clusters)Tj
3.2314 0 Td
(are)Tj
1.4514 0 Td
(shown.)Tj
3.0727 0 Td
(The)Tj
1.7801 0 Td
(siderophore)Tj
5.023 0 Td
(receptors)Tj
3.9175 0 Td
(were)Tj
2.1259 0 Td
(considered)Tj
4.5978 0 Td
(separately,)Tj
4.4107 0 Td
(and)Tj
1.7291 0 Td
(mapped)Tj
3.4582 0 Td
(onto)Tj
-34.7978 -1.2983 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.2564 0 Td
(network.)Tj
3.7757 0 Td
(Species)Tj
3.1124 0 Td
(with)Tj
1.9956 0 Td
(positive)Tj
3.3165 0 Td
(hits,)Tj
1.8992 0 Td
(but)Tj
1.5534 0 Td
(not)Tj
1.576 0 Td
(included)Tj
3.7134 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(MLSA)Tj
2.812 0 Td
(dataset,)Tj
3.2258 0 Td
(were)Tj
-33.2048 -1.2983 Td
(placed)Tj
2.7892 0 Td
(onto)Tj
2.0806 0 Td
(the)Tj
1.474 0 Td
(network)Tj
3.549 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(literature.)Tj
4.1046 0 Td
(Unclassified)Tj
/F13 1 Tf
5.8903 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.3745 0 Td
(strains)Tj
2.8629 0 Td
(are)Tj
1.4457 0 Td
(not)Tj
-34.7865 -1.3039 Td
(shown)Tj
2.8459 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(network,)Tj
3.7758 0 Td
(but)Tj
1.5533 0 Td
(can)Tj
1.6271 0 Td
(be)Tj
1.1509 0 Td
(found)Tj
2.6192 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0374 0 Td
(S1)Tj
0 g
1.1679 0 Td
(and)Tj
0.83 0.64 0.02 0 k
1.7291 0 Td
(S2)Tj
0 g
1.1736 0 Td
(Tables.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 256.0251 cm
BT
/F14 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Phylogenetic)Tj
5.589 0 Td
(analysis)Tj
3.5055 0 Td
(of)Tj
1.0677 0 Td
(siderophore)Tj
5.2394 0 Td
(biosynthesis)Tj
5.3339 0 Td
(systems)Tj
3.4442 0 Td
(and)Tj
1.7905 0 Td
(receptors)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 239.0173 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Amino)Tj
3.0443 0 Td
(acid)Tj
1.8709 0 Td
(sequences)Tj
4.2236 0 Td
(of)Tj
1.0148 0 Td
(proteins)Tj
3.5093 0 Td
(involved)Tj
3.651 0 Td
(in)Tj
1.0374 0 Td
(siderophore)Tj
5.023 0 Td
(biosynthesis)Tj
5.1023 0 Td
(were)Tj
2.126 0 Td
(aligned)Tj
3.1294 0 Td
(using)Tj
-33.732 -1.3039 Td
(ClustalW)Tj
3.9628 0 Td
([)Tj
0.83 0.64 0.02 0 k
(57)Tj
0 g
(].)Tj
2.0749 0 Td
(Proteins)Tj
3.5546 0 Td
(belonging)Tj
4.2009 0 Td
(to)Tj
1.0262 0 Td
(same)Tj
2.2563 0 Td
(clusters)Tj
3.2315 0 Td
(were)Tj
2.1203 0 Td
(concatenated)Tj
5.5105 0 Td
(using)Tj
2.3925 0 Td
(SplitsTree4)Tj
4.6884 0 Td
([)Tj
0.83 0.64 0.02 0 k
(56)Tj
0 g
(])Tj
-35.0189 -1.2982 Td
(and)Tj
1.7291 0 Td
(exported)Tj
3.753 0 Td
(to)Tj
1.0262 0 Td
(Fasta)Tj
2.2733 0 Td
(format,)Tj
3.1635 0 Td
(thus)Tj
1.9389 0 Td
(generating)Tj
4.4617 0 Td
(the)Tj
1.4683 0 Td
(final)Tj
2.0069 0 Td
(datasets.)Tj
3.583 0 Td
(Next,)Tj
2.3697 0 Td
(Mega6)Tj
2.9084 0 Td
([)Tj
0.83 0.64 0.02 0 k
(58)Tj
0 g
(])Tj
1.8538 0 Td
(was)Tj
1.6951 0 Td
(used)Tj
2.0636 0 Td
(to)Tj
-36.2945 -1.2983 Td
(generate)Tj
3.6056 0 Td
(Maximum)Tj
4.4447 0 Td
(Likelihood)Tj
4.5297 0 Td
(\(ML\))Tj
2.3301 0 Td
(trees)Tj
2.0976 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.474 0 Td
(individual)Tj
4.286 0 Td
(siderophore)Tj
5.0229 0 Td
(biosynthesis)Tj
-31.538 -1.3039 Td
(datasets.)Tj
3.5829 0 Td
(The)Tj
1.7802 0 Td
(robustness)Tj
4.49 0 Td
(of)Tj
1.0148 0 Td
(nodes)Tj
2.5852 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(resulting)Tj
3.7304 0 Td
(phylogenies)Tj
4.9606 0 Td
(was)Tj
1.7008 0 Td
(tested)Tj
2.5511 0 Td
(by)Tj
1.1792 0 Td
(running)Tj
3.498 0 Td
(Bootstrap)Tj
-33.579 -1.2983 Td
(analyses,)Tj
3.7076 0 Td
(using)Tj
2.3868 0 Td
(the)Tj
1.474 0 Td
(ML)Tj
1.6498 0 Td
(method)Tj
3.3221 0 Td
(\(2000)Tj
2.4605 0 Td
(replicates,)Tj
4.2123 0 Td
(JTT)Tj
1.7744 0 Td
(substitution)Tj
4.989 0 Td
(model,)Tj
2.9707 0 Td
(uniform)Tj
3.5489 0 Td
(rates,)Tj
2.3301 0 Td
(and)Tj
-34.8262 -1.2982 Td
(`Complete)Tj
4.3426 0 Td
(deletion')Tj
3.6793 0 Td
(in)Tj
1.0319 0 Td
(gap)Tj
1.6384 0 Td
(handling\).)Tj
-9.496 -1.2983 Td
(To)Tj
1.3379 0 Td
(address)Tj
3.2315 0 Td
(inheritance)Tj
4.7508 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(siderophore)Tj
5.0229 0 Td
(biosynthesis)Tj
5.108 0 Td
(systems,)Tj
3.5206 0 Td
(we)Tj
1.3323 0 Td
(next)Tj
1.9502 0 Td
(constructed)Tj
4.9323 0 Td
(host)Tj
-34.8659 -1.3039 Td
(phylogenies)Tj
4.9605 0 Td
(of)Tj
1.0148 0 Td
(same)Tj
2.2564 0 Td
(taxa)Tj
1.8539 0 Td
(as)Tj
1.0148 0 Td
(those)Tj
2.3357 0 Td
(containing)Tj
4.5297 0 Td
(the)Tj
1.4684 0 Td
(siderophore)Tj
5.0229 0 Td
(systems.)Tj
3.5263 0 Td
(Host)Tj
2.1543 0 Td
(trees)Tj
2.0976 0 Td
(were)Tj
2.1203 0 Td
(based)Tj
-34.3556 -1.2983 Td
(on)Tj
1.2755 0 Td
(concatenated)Tj
5.5105 0 Td
(datasets)Tj
3.3562 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(same)Tj
2.262 0 Td
(eight)Tj
2.1997 0 Td
(genes)Tj
2.4434 0 Td
(as)Tj
1.0148 0 Td
(described)Tj
4.0479 0 Td
(above.)Tj
2.7722 0 Td
(ML-trees)Tj
3.8778 0 Td
(were)Tj
2.126 0 Td
(con-)Tj
-33.3692 -1.2983 Td
(structed)Tj
3.4525 0 Td
(using)Tj
2.3868 0 Td
(the)Tj
1.4683 0 Td
(Tamura-Nei)Tj
5.1987 0 Td
(model)Tj
2.7439 0 Td
([)Tj
0.83 0.64 0.02 0 k
(59)Tj
0 g
(],)Tj
2.075 0 Td
(and)Tj
1.7291 0 Td
(all)Tj
1.1452 0 Td
(gaps)Tj
2.0013 0 Td
(and)Tj
1.7291 0 Td
(missing)Tj
3.3108 0 Td
(data)Tj
1.9106 0 Td
(were)Tj
2.1259 0 Td
(removed.)Tj
3.9685 0 Td
(Phy-)Tj
-35.2457 -1.3039 Td
(logenies)Tj
3.4582 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(vibrioferrin)Tj
4.8642 0 Td
(\(PvsABCDE\),)Tj
5.7316 0 Td
(piscibactin)Tj
4.5354 0 Td
(\(Irp123459\),)Tj
5.2044 0 Td
(and)Tj
1.7348 0 Td
(aerobactin)Tj
4.4334 0 Td
(\(IucABCD\))Tj
-32.4508 -1.2982 Td
(biosynthesis)Tj
5.1023 0 Td
(systems,)Tj
3.5263 0 Td
(and)Tj
1.7291 0 Td
(their)Tj
2.1089 0 Td
(corresponding)Tj
6.0548 0 Td
(MLSA)Tj
2.812 0 Td
(host)Tj
1.9162 0 Td
(trees,)Tj
2.3244 0 Td
(were)Tj
2.1203 0 Td
(rooted)Tj
2.8573 0 Td
(on)Tj
/F13 1 Tf
1.2756 0 Td
[()20()12()12()15()-13()14()11(\r)-9()4()]TJ
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
35.9997 703.561 m
575.9997 703.561 l
575.9997 703.061 l
35.9997 703.061 l
f*
197.2029 703.061 m
197.2029 690.5611 l
196.7029 690.5611 l
196.7029 703.061 l
f*
196.7029 690.5611 m
35.9997 690.5611 l
35.9997 691.0611 l
196.7029 691.0611 l
f*
356.8113 703.061 m
356.8113 690.5611 l
356.3113 690.5611 l
356.3113 703.061 l
f*
356.3113 690.5611 m
197.2029 690.5611 l
197.2029 691.0611 l
356.3113 691.0611 l
f*
486.2662 703.061 m
486.2662 690.5611 l
485.7661 690.5611 l
485.7661 703.061 l
f*
485.7661 690.5611 m
356.8113 690.5611 l
356.8113 691.0611 l
485.7661 691.0611 l
f*
575.9997 690.5611 m
486.2662 690.5611 l
486.2662 691.0611 l
575.9997 691.0611 l
f*
197.2029 690.5611 m
197.2029 678.0611 l
196.7029 678.0611 l
196.7029 690.5611 l
f*
196.7029 678.0611 m
35.9997 678.0611 l
35.9997 678.5612 l
196.7029 678.5612 l
f*
356.8113 690.5611 m
356.8113 678.0611 l
356.3113 678.0611 l
356.3113 690.5611 l
f*
356.3113 678.0611 m
197.2029 678.0611 l
197.2029 678.5612 l
356.3113 678.5612 l
f*
486.2662 690.5611 m
486.2662 678.0611 l
485.7661 678.0611 l
485.7661 690.5611 l
f*
485.7661 678.0611 m
356.8113 678.0611 l
356.8113 678.5612 l
485.7661 678.5612 l
f*
575.9997 678.0611 m
486.2662 678.0611 l
486.2662 678.5612 l
575.9997 678.5612 l
f*
197.2029 678.0611 m
197.2029 665.5612 l
196.7029 665.5612 l
196.7029 678.0611 l
f*
196.7029 665.5612 m
35.9997 665.5612 l
35.9997 666.0612 l
196.7029 666.0612 l
f*
356.8113 678.0611 m
356.8113 665.5612 l
356.3113 665.5612 l
356.3113 678.0611 l
f*
356.3113 665.5612 m
197.2029 665.5612 l
197.2029 666.0612 l
356.3113 666.0612 l
f*
486.2662 678.0611 m
486.2662 665.5612 l
485.7661 665.5612 l
485.7661 678.0611 l
f*
485.7661 665.5612 m
356.8113 665.5612 l
356.8113 666.0612 l
485.7661 666.0612 l
f*
575.9997 665.5612 m
486.2662 665.5612 l
486.2662 666.0612 l
575.9997 666.0612 l
f*
197.2029 665.5612 m
197.2029 653.0613 l
196.7029 653.0613 l
196.7029 665.5612 l
f*
196.7029 653.0613 m
35.9997 653.0613 l
35.9997 653.5613 l
196.7029 653.5613 l
f*
356.8113 665.5612 m
356.8113 653.0613 l
356.3113 653.0613 l
356.3113 665.5612 l
f*
356.3113 653.0613 m
197.2029 653.0613 l
197.2029 653.5613 l
356.3113 653.5613 l
f*
486.2662 665.5612 m
486.2662 653.0613 l
485.7661 653.0613 l
485.7661 665.5612 l
f*
485.7661 653.0613 m
356.8113 653.0613 l
356.8113 653.5613 l
485.7661 653.5613 l
f*
575.9997 653.0613 m
486.2662 653.0613 l
486.2662 653.5613 l
575.9997 653.5613 l
f*
197.2029 653.0613 m
197.2029 640.5613 l
196.7029 640.5613 l
196.7029 653.0613 l
f*
196.7029 640.5613 m
35.9997 640.5613 l
35.9997 641.0614 l
196.7029 641.0614 l
f*
356.8113 653.0613 m
356.8113 640.5613 l
356.3113 640.5613 l
356.3113 653.0613 l
f*
356.3113 640.5613 m
197.2029 640.5613 l
197.2029 641.0614 l
356.3113 641.0614 l
f*
486.2662 653.0613 m
486.2662 640.5613 l
485.7661 640.5613 l
485.7661 653.0613 l
f*
485.7661 640.5613 m
356.8113 640.5613 l
356.8113 641.0614 l
485.7661 641.0614 l
f*
575.9997 640.5613 m
486.2662 640.5613 l
486.2662 641.0614 l
575.9997 641.0614 l
f*
197.2029 640.5613 m
197.2029 618.5614 l
196.7029 618.5614 l
196.7029 640.5613 l
f*
196.7029 618.5614 m
35.9997 618.5614 l
35.9997 619.0614 l
196.7029 619.0614 l
f*
356.8113 640.5613 m
356.8113 618.5614 l
356.3113 618.5614 l
356.3113 640.5613 l
f*
356.3113 618.5614 m
197.2029 618.5614 l
197.2029 619.0614 l
356.3113 619.0614 l
f*
486.2662 640.5613 m
486.2662 618.5614 l
485.7661 618.5614 l
485.7661 640.5613 l
f*
485.7661 618.5614 m
356.8113 618.5614 l
356.8113 619.0614 l
485.7661 619.0614 l
f*
575.9997 618.5614 m
486.2662 618.5614 l
486.2662 619.0614 l
575.9997 619.0614 l
f*
197.2029 618.5614 m
197.2029 606.0614 l
196.7029 606.0614 l
196.7029 618.5614 l
f*
196.7029 606.0614 m
35.9997 606.0614 l
35.9997 606.5614 l
196.7029 606.5614 l
f*
356.8113 618.5614 m
356.8113 606.0614 l
356.3113 606.0614 l
356.3113 618.5614 l
f*
356.3113 606.0614 m
197.2029 606.0614 l
197.2029 606.5614 l
356.3113 606.5614 l
f*
486.2662 618.5614 m
486.2662 606.0614 l
485.7661 606.0614 l
485.7661 618.5614 l
f*
485.7661 606.0614 m
356.8113 606.0614 l
356.8113 606.5614 l
485.7661 606.5614 l
f*
575.9997 606.0614 m
486.2662 606.0614 l
486.2662 606.5614 l
575.9997 606.5614 l
f*
197.2029 606.0614 m
197.2029 593.5615 l
196.7029 593.5615 l
196.7029 606.0614 l
f*
196.7029 593.5615 m
35.9997 593.5615 l
35.9997 594.0615 l
196.7029 594.0615 l
f*
356.8113 606.0614 m
356.8113 593.5615 l
356.3113 593.5615 l
356.3113 606.0614 l
f*
356.3113 593.5615 m
197.2029 593.5615 l
197.2029 594.0615 l
356.3113 594.0615 l
f*
486.2662 606.0614 m
486.2662 593.5615 l
485.7661 593.5615 l
485.7661 606.0614 l
f*
485.7661 593.5615 m
356.8113 593.5615 l
356.8113 594.0615 l
485.7661 594.0615 l
f*
575.9997 593.5615 m
486.2662 593.5615 l
486.2662 594.0615 l
575.9997 594.0615 l
f*
197.2029 593.5615 m
197.2029 571.5615 l
196.7029 571.5615 l
196.7029 593.5615 l
f*
196.7029 571.5615 m
35.9997 571.5615 l
35.9997 572.0615 l
196.7029 572.0615 l
f*
356.8113 593.5615 m
356.8113 571.5615 l
356.3113 571.5615 l
356.3113 593.5615 l
f*
356.3113 571.5615 m
197.2029 571.5615 l
197.2029 572.0615 l
356.3113 572.0615 l
f*
486.2662 593.5615 m
486.2662 571.5615 l
485.7661 571.5615 l
485.7661 593.5615 l
f*
485.7661 571.5615 m
356.8113 571.5615 l
356.8113 572.0615 l
485.7661 572.0615 l
f*
575.9997 571.5615 m
486.2662 571.5615 l
486.2662 572.0615 l
575.9997 572.0615 l
f*
197.2029 571.5615 m
197.2029 549.5615 l
196.7029 549.5615 l
196.7029 571.5615 l
f*
196.7029 549.5615 m
35.9997 549.5615 l
35.9997 550.0616 l
196.7029 550.0616 l
f*
356.8113 571.5615 m
356.8113 549.5615 l
356.3113 549.5615 l
356.3113 571.5615 l
f*
356.3113 549.5615 m
197.2029 549.5615 l
197.2029 550.0616 l
356.3113 550.0616 l
f*
486.2662 571.5615 m
486.2662 549.5615 l
485.7661 549.5615 l
485.7661 571.5615 l
f*
485.7661 549.5615 m
356.8113 549.5615 l
356.8113 550.0616 l
485.7661 550.0616 l
f*
575.9997 549.5615 m
486.2662 549.5615 l
486.2662 550.0616 l
575.9997 550.0616 l
f*
197.2029 549.5615 m
197.2029 537.0616 l
196.7029 537.0616 l
196.7029 549.5615 l
f*
196.7029 537.0616 m
35.9997 537.0616 l
35.9997 537.5616 l
196.7029 537.5616 l
f*
356.8113 549.5615 m
356.8113 537.0616 l
356.3113 537.0616 l
356.3113 549.5615 l
f*
356.3113 537.0616 m
197.2029 537.0616 l
197.2029 537.5616 l
356.3113 537.5616 l
f*
486.2662 549.5615 m
486.2662 537.0616 l
485.7661 537.0616 l
485.7661 549.5615 l
f*
485.7661 537.0616 m
356.8113 537.0616 l
356.8113 537.5616 l
485.7661 537.5616 l
f*
575.9997 537.0616 m
486.2662 537.0616 l
486.2662 537.5616 l
575.9997 537.5616 l
f*
197.2029 537.0616 m
197.2029 524.5617 l
196.7029 524.5617 l
196.7029 537.0616 l
f*
196.7029 524.5617 m
35.9997 524.5617 l
35.9997 525.0617 l
196.7029 525.0617 l
f*
356.8113 537.0616 m
356.8113 524.5617 l
356.3113 524.5617 l
356.3113 537.0616 l
f*
356.3113 524.5617 m
197.2029 524.5617 l
197.2029 525.0617 l
356.3113 525.0617 l
f*
486.2662 537.0616 m
486.2662 524.5617 l
485.7661 524.5617 l
485.7661 537.0616 l
f*
485.7661 524.5617 m
356.8113 524.5617 l
356.8113 525.0617 l
485.7661 525.0617 l
f*
575.9997 524.5617 m
486.2662 524.5617 l
486.2662 525.0617 l
575.9997 525.0617 l
f*
197.2029 524.5617 m
197.2029 512.0617 l
196.7029 512.0617 l
196.7029 524.5617 l
f*
196.7029 512.0617 m
35.9997 512.0617 l
35.9997 512.5618 l
196.7029 512.5618 l
f*
356.8113 524.5617 m
356.8113 512.0617 l
356.3113 512.0617 l
356.3113 524.5617 l
f*
356.3113 512.0617 m
197.2029 512.0617 l
197.2029 512.5618 l
356.3113 512.5618 l
f*
486.2662 524.5617 m
486.2662 512.0617 l
485.7661 512.0617 l
485.7661 524.5617 l
f*
485.7661 512.0617 m
356.8113 512.0617 l
356.8113 512.5618 l
485.7661 512.5618 l
f*
575.9997 512.0617 m
486.2662 512.0617 l
486.2662 512.5618 l
575.9997 512.5618 l
f*
197.2029 512.0617 m
197.2029 499.5618 l
196.7029 499.5618 l
196.7029 512.0617 l
f*
196.7029 499.5618 m
35.9997 499.5618 l
35.9997 500.0618 l
196.7029 500.0618 l
f*
356.8113 512.0617 m
356.8113 499.5618 l
356.3113 499.5618 l
356.3113 512.0617 l
f*
356.3113 499.5618 m
197.2029 499.5618 l
197.2029 500.0618 l
356.3113 500.0618 l
f*
486.2662 512.0617 m
486.2662 499.5618 l
485.7661 499.5618 l
485.7661 512.0617 l
f*
485.7661 499.5618 m
356.8113 499.5618 l
356.8113 500.0618 l
485.7661 500.0618 l
f*
575.9997 499.5618 m
486.2662 499.5618 l
486.2662 500.0618 l
575.9997 500.0618 l
f*
0.83 0.64 0.02 0 k
491.9811 679.9748 m
499.6346 679.9748 l
h
f*
491.9811 667.5024 m
499.6346 667.5024 l
h
f*
491.9811 654.9732 m
499.6346 654.9732 l
h
f*
491.9811 642.5008 m
499.6346 642.5008 l
h
f*
491.9811 629.9717 m
499.6346 629.9717 l
h
f*
491.9811 607.9748 m
499.6346 607.9748 l
h
f*
491.9811 595.5024 m
499.6346 595.5024 l
h
f*
491.9811 582.9732 m
499.6346 582.9732 l
h
f*
491.9811 560.9764 m
499.6346 560.9764 l
h
f*
491.9811 538.9795 m
499.6346 538.9795 l
h
f*
491.9811 526.5071 m
499.6346 526.5071 l
h
f*
491.9811 513.978 m
499.6346 513.978 l
h
f*
491.9811 501.5055 m
499.6346 501.5055 l
h
f*
36 486.4819 m
186.7465 486.4819 l
h
f*
0 g
7.9999 0 0 7.9999 36 708.3779 cm
BT
/F14 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(2.)Tj
1.1763 0 Td
(RefSeq)Tj
3.0757 0 Td
(accession)Tj
4.0748 0 Td
(number)Tj
3.2882 0 Td
(s)Tj
0.6024 0 Td
(of)Tj
1.063 0 Td
(known)Tj
/F16 1 Tf
3.026 0 Td
[()48()12()4()-12()-1()4()5()5()3( )]TJ
4.9394 0 Td
[( )]TJ
/F14 1 Tf
0.6307 0 Td
(siderophore)Tj
5.2158 0 Td
(recepto)Tj
3.0756 0 Td
(r)Tj
0.6236 0 Td
(proteins)Tj
3.4442 0 Td
(.)Tj
0 Tc
-36.7869 -1.8496 Td
(Organism)Tj
20.4025 0 Td
(Recepto)Tj
3.3591 0 Td
(r)Tj
16.5898 0 Td
(Transpor)Tj
3.9332 0 Td
(t)Tj
12.2457 0 Td
(Ref)Tj
/F13 1 Tf
-56.5303 -1.5661 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1196 0 Td
[()18()12()18()4()1()-4()]TJ
/F8 1 Tf
19.4033 0 Td
(IutA)Tj
2.0906 0 Td
(\(WP_00084)Tj
4.7552 0 Td
(3157.1\))Tj
13.1103 0 Td
(Aerobac)Tj
3.3591 0 Td
(tin)Tj
12.8198 0 Td
([)Tj
0.83 0.64 0.02 0 k
(53)Tj
0 g
(])Tj
/F13 1 Tf
-56.6579 -1.5591 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1126 0 Td
[()-3()11()12()6()11()18()4()1()4()]TJ
4.2449 0 Td
[()]TJ
/F8 1 Tf
15.1654 0 Td
(BitA)Tj
2.0694 0 Td
(\(WP_01254)Tj
4.7551 0 Td
(9028.1\))Tj
13.1316 0 Td
(Bisucabe)Tj
3.5363 0 Td
(rin)Tj
12.6426 0 Td
([)Tj
0.83 0.64 0.02 0 k
(47)Tj
0 g
(])Tj
/F13 1 Tf
-56.6579 -1.5661 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1196 0 Td
[( )4()16(\r)20()11()6()6()2()6()10()15()]TJ
5.1308 0 Td
[()7()4()1()-4()]TJ
/F8 1 Tf
14.2725 0 Td
(PvuA)Tj
2.4662 0 Td
(\(WP_05762)Tj
4.7552 0 Td
(0147.1\))Tj
12.7347 0 Td
(Vibriof)Tj
2.9126 0 Td
(errin)Tj
13.2663 0 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(])Tj
/F13 1 Tf
-56.6579 -1.5591 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1196 0 Td
[( )4()16(\r)20()11()6()6()2()6()10()15()]TJ
5.1308 0 Td
[()7()4()1()-4()]TJ
/F8 1 Tf
14.2725 0 Td
(PeuA)Tj
2.4308 0 Td
(\(WP_0054796)Tj
5.7118 0 Td
(24.1\))Tj
11.8135 0 Td
(Enteroba)Tj
3.6709 0 Td
(ctin)Tj
12.508 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(])Tj
/F13 1 Tf
-56.6579 -1.5662 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1196 0 Td
[()13()6()10()4()2(\r)20()6()]TJ
/F8 1 Tf
19.4033 0 Td
(ViuA)Tj
2.4166 0 Td
(\(WP_00)Tj
3.3166 0 Td
(0279435.1\))Tj
14.2229 0 Td
(Vibriobact)Tj
4.2945 0 Td
(in)Tj
-4.2945 -1.1834 Td
(Fluvibac)Tj
3.4016 0 Td
(tin)Tj
12.7773 1.1834 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(])Tj
/F13 1 Tf
-56.6579 -2.7496 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1196 0 Td
[()16()13( )-8()12()4()4()4()16(\r)-9()12()]TJ
/F8 1 Tf
19.4033 0 Td
(FvtA)Tj
2.204 0 Td
(\(WP_01928)Tj
4.7552 0 Td
(1795.1\))Tj
12.9969 0 Td
(Vanchro)Tj
3.515 0 Td
(bactin)Tj
12.6639 0 Td
([)Tj
0.83 0.64 0.02 0 k
(42)Tj
0 g
(])Tj
/F13 1 Tf
-56.6579 -1.5591 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1196 0 Td
[()16()13( )-8()12()4()4()4()16(\r)-9()12()]TJ
/F8 1 Tf
19.4033 0 Td
(FatA)Tj
2.1827 0 Td
(\(WP_01115)Tj
4.7552 0 Td
(4638.1\))Tj
13.0182 0 Td
(Anguiba)Tj
3.4441 0 Td
(ctin)Tj
12.7348 0 Td
([)Tj
0.83 0.64 0.02 0 k
(54)Tj
0 g
(])Tj
/F13 1 Tf
-56.6579 -1.5661 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1196 0 Td
[()13()6()10()4()2(\r)20()6()]TJ
/F8 1 Tf
19.4033 0 Td
(VctA)Tj
2.3386 0 Td
(\(WP_00035)Tj
4.7552 0 Td
(0325.1\))Tj
12.8623 0 Td
(Enteroba)Tj
3.6709 0 Td
(ctin)Tj
-3.6709 -1.1835 Td
(Fluvibac)Tj
3.4016 0 Td
(tin)Tj
12.7773 1.1835 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(])Tj
/F13 1 Tf
-56.6579 -2.7496 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1196 0 Td
[()13()6()10()4()2(\r)20()6()]TJ
/F8 1 Tf
19.4033 0 Td
(IrgA)Tj
2.1048 0 Td
(\(WP_00)Tj
3.3165 0 Td
(0086048.1\))Tj
14.5348 0 Td
(Enteroba)Tj
3.6709 0 Td
(ctin)Tj
-3.6709 -1.1835 Td
(Fluvibac)Tj
3.4016 0 Td
(tin)Tj
12.7773 1.1835 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(])Tj
/F13 1 Tf
-56.6579 -2.7497 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1196 0 Td
[()-13()4()12()18()12()-8()4()1()-4()]TJ
/F8 1 Tf
19.4033 0 Td
(VvuA)Tj
2.6009 0 Td
(\(WP_01572)Tj
4.7551 0 Td
(8225.1\))Tj
12.6001 0 Td
(Vulnibact)Tj
3.9615 0 Td
(in)Tj
12.2174 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(])Tj
/F13 1 Tf
-56.6579 -1.559 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1196 0 Td
[()13()6()10()4()2(\r)20()6()]TJ
/F8 1 Tf
19.4033 0 Td
(FhuA)Tj
2.5087 0 Td
(\(WP_0530)Tj
4.2733 0 Td
(43596.1\))Tj
13.1741 0 Td
(Ferrichro)Tj
3.8056 0 Td
(me)Tj
12.3733 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(])Tj
/F13 1 Tf
-56.6579 -1.5662 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1196 0 Td
[()-8()12(\r)-9()18()-4()10()10()12()]TJ
/F8 1 Tf
19.4033 0 Td
(DesA)Tj
2.4449 0 Td
(\(WP_00472)Tj
4.7552 0 Td
(5209.1\))Tj
12.756 0 Td
(Deferox)Tj
3.2244 0 Td
(amine)Tj
2.7355 0 Td
(B)Tj
10.219 0 Td
([)Tj
0.83 0.64 0.02 0 k
(55)Tj
0 g
(])Tj
/F13 1 Tf
-56.6579 -1.5591 Td
[()]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.0063 0 Td
[()4()16()-3()15()4()6()]TJ
3.848 0 Td
[()10()14()7()10( )]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
2.6079 0 Td
[()2()-4()-3()1()4()1()4()4()]TJ
/F8 1 Tf
13.0607 0 Td
(FrpA)Tj
2.3386 0 Td
(\(AKQ52529.)Tj
5.067 0 Td
(1\))Tj
12.5505 0 Td
(Piscibact)Tj
3.5575 0 Td
(in)Tj
12.6214 0 Td
([)Tj
0.83 0.64 0.02 0 k
(37)Tj
0 g
(])Tj
0.83 0.64 0.02 0 k
/F10 1 Tf
-0.025 Tc
-56.6579 -1.8779 Td
(https://do)Tj
3.5575 0 Td
(i.org/10.1371/j)Tj
5.4425 0 Td
(ournal.pone)Tj
4.4079 0 Td
(.0191860.t002)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 447.0803 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Sideropho)Tj
4.4716 0 Td
(re)Tj
1.0985 0 Td
(systems)Tj
3.8409 0 Td
(in)Tj
/F7 1 Tf
0.978 0 Td
(Vibrionac)Tj
4.0819 0 Td
(eae)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01918)Tj
4.089 0 Td
(60)Tj
0 g
2.0906 0 Td
(February)Tj
4.1599 0 Td
(14,)Tj
1.5874 0 Td
(2018)Tj
33.1585 0 Td
(5)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
207 0 obj
<>stream
endstream
endobj
208 0 obj
<>stream
endstream
endobj
209 0 obj
<>stream
endstream
endobj
210 0 obj
<>stream
endstream
endobj
211 0 obj
<>stream
endstream
endobj
212 0 obj
<>stream
endstream
endobj
213 0 obj
<>stream
endstream
endobj
214 0 obj
<>stream
endstream
endobj
215 0 obj
<>stream
endstream
endobj
216 0 obj
<>stream
endstream
endobj
217 0 obj
<>stream
endstream
endobj
218 0 obj
<>stream
endstream
endobj
219 0 obj
<>stream
endstream
endobj
220 0 obj
<>stream
endstream
endobj
221 0 obj
<>stream
endstream
endobj
222 0 obj
<>stream
endstream
endobj
223 0 obj
<>stream
endstream
endobj
224 0 obj
<>stream
endstream
endobj
225 0 obj
<>stream
endstream
endobj
226 0 obj
<>stream
endstream
endobj
227 0 obj
<>stream
endstream
endobj
228 0 obj
<>stream
BT
66.402 0 Td
(20)Tj
ET
Q
endstream
endobj
229 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 230 0 R/Contents 231 0 R/TrimBox[0 0 612 792]>>
endobj
230 0 obj
[232 0 R 233 0 R 234 0 R 235 0 R 236 0 R 237 0 R 238 0 R 239 0 R 240 0 R 241 0 R 242 0 R 243 0 R 244 0 R 245 0 R 246 0 R 247 0 R 248 0 R]
endobj
232 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref058)>>
endobj
233 0 obj
<>/Border[0 0 0]/Dest(Rsec002)>>
endobj
234 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.g001)>>
endobj
235 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.t001)>>
endobj
236 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.g001)>>
endobj
237 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.g001)>>
endobj
238 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.s003)>>
endobj
239 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref060)>>
endobj
240 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref061)>>
endobj
241 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref062)>>
endobj
242 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref063)>>
endobj
243 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref064)>>
endobj
244 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.ref052)>>
endobj
245 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.g001)>>
endobj
246 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.s001)>>
endobj
247 0 obj
<>/Border[0 0 0]/Dest(Rpone.0191860.t002)>>
endobj
248 0 obj
<>/Border[0 0 0]/A 249 0 R>>
endobj
249 0 obj
<>
endobj
231 0 obj
[250 0 R 251 0 R 252 0 R 253 0 R 254 0 R 255 0 R 256 0 R 257 0 R 258 0 R 259 0 R 260 0 R 261 0 R 262 0 R 263 0 R 264 0 R 265 0 R]
endobj
250 0 obj
<>stream
q
0.83 0.64 0.02 0 k
550.148 680.315 m
559.6724 680.315 l
h
f*
443.6787 523.8992 m
536.7685 523.8992 l
h
f*
303.3071 510.9165 m
323.2063 510.9165 l
h
f*
342.9921 510.9165 m
372.6425 510.9165 l
h
f*
322.1291 471.9118 m
341.9717 471.9118 l
h
f*
509.726 341.915 m
529.6819 341.915 l
h
f*
254.211 328.9323 m
278.9858 328.9323 l
h
f*
396.1134 315.9496 m
405.8079 315.9496 l
h
f*
408.189 315.9496 m
417.8268 315.9496 l
h
f*
407.8488 302.9102 m
417.5433 302.9102 l
h
f*
556.2709 302.9102 m
565.9654 302.9102 l
h
f*
351.4961 289.9276 m
361.1906 289.9276 l
h
f*
319.4646 263.9055 m
329.1591 263.9055 l
h
f*
478.2047 250.9228 m
534.6709 250.9228 l
h
f*
363.1181 172.9134 m
397.1339 172.9134 l
h
f*
535.1811 94.9039 m
564.378 94.9039 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F13 1 Tf
1 TL
-0.004 Tc
0 0 Td
[()3()4()4()16()18()-4()]TJ
/F8 1 Tf
(,)Tj
/F13 1 Tf
3.6793 0 Td
[()4()6()12()11()13()4()6()-4()11()2(\r)-9()12()12()]TJ
6.4629 0 Td
[( )11(\r)20()11()-8()12()6()12()12()]TJ
/F8 1 Tf
(,)Tj
4.8699 0 Td
(and)Tj
/F13 1 Tf
1.7292 0 Td
[(!)13(\r)-9()12()6()11()22()7()4()]TJ
4.3483 0 Td
[()6()10()4()12()-4()-3()6()]TJ
/F8 1 Tf
(,)Tj
3.3618 0 Td
(respectively.)Tj
5.108 0 Td
(The)Tj
1.7859 0 Td
(phylogeny)Tj
4.3653 0 Td
(of)Tj
-35.7106 -1.3039 Td
(siderophore)Tj
5.0229 0 Td
(receptors)Tj
3.9175 0 Td
(was)Tj
1.7007 0 Td
(constructed)Tj
4.9266 0 Td
(essentially)Tj
4.286 0 Td
(as)Tj
1.0148 0 Td
(described)Tj
4.0535 0 Td
(above.)Tj
2.7723 0 Td
(Briefly,)Tj
3.0727 0 Td
(amino)Tj
2.7949 0 Td
(acid)Tj
-33.5619 -1.2982 Td
(sequences)Tj
4.2179 0 Td
(of)Tj
1.0148 0 Td
(homologous)Tj
5.193 0 Td
(receptor)Tj
3.5603 0 Td
(sequences)Tj
4.2179 0 Td
(were)Tj
2.1203 0 Td
(aligned)Tj
3.1351 0 Td
(using)Tj
2.3868 0 Td
(ClustalW,)Tj
4.1896 0 Td
(and)Tj
1.7291 0 Td
(Mega6)Tj
2.9083 0 Td
([)Tj
0.83 0.64 0.02 0 k
(58)Tj
0 g
(])Tj
-34.6731 -1.2983 Td
(was)Tj
1.6951 0 Td
(then)Tj
2.0182 0 Td
(used)Tj
2.0636 0 Td
(to)Tj
1.0262 0 Td
(make)Tj
2.3924 0 Td
(ML-trees.)Tj
4.1045 0 Td
(Bootstrap)Tj
4.0932 0 Td
(analysis)Tj
3.3279 0 Td
(was)Tj
1.6951 0 Td
(done)Tj
2.228 0 Td
(using)Tj
2.3924 0 Td
(the)Tj
1.4684 0 Td
(ML)Tj
1.6497 0 Td
(method,)Tj
3.549 0 Td
(2000)Tj
-33.7037 -1.2983 Td
(pseudoreplicates,)Tj
7.0752 0 Td
(the)Tj
1.4683 0 Td
(JTT)Tj
1.7745 0 Td
(model,)Tj
2.965 0 Td
(uniform)Tj
3.549 0 Td
(rates,)Tj
2.3357 0 Td
(and)Tj
1.7291 0 Td
(complete)Tj
3.8778 0 Td
(deletion)Tj
3.4639 0 Td
(of)Tj
1.0148 0 Td
(gaps.)Tj
2.2224 0 Td
(Corresponding)Tj
-31.4757 -1.3039 Td
(MLSA)Tj
2.8119 0 Td
(trees)Tj
2.0976 0 Td
(were)Tj
2.1203 0 Td
(constructed)Tj
4.9323 0 Td
(as)Tj
1.0148 0 Td
(described)Tj
4.0478 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(cluster.)Tj
3.0954 0 Td
(The)Tj
1.7859 0 Td
(receptor)Tj
3.5546 0 Td
(phylogenies)Tj
4.9606 0 Td
(were)Tj
2.126 0 Td
(com-)Tj
-35.4045 -1.2982 Td
(pared)Tj
2.4944 0 Td
(to)Tj
1.0262 0 Td
(host)Tj
1.9105 0 Td
(trees,)Tj
2.3244 0 Td
(which)Tj
2.6475 0 Td
(were)Tj
2.126 0 Td
(constructed)Tj
4.9266 0 Td
(as)Tj
1.0148 0 Td
(described)Tj
4.0535 0 Td
(above.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 599.9811 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
3.7984 0 Td
(and)Tj
1.989 0 Td
(discussion)Tj
/F14 1 Tf
-5.7874 -1.4976 Td
(Compilation)Tj
5.5323 0 Td
(of)Tj
1.0677 0 Td
(siderophore)Tj
5.2394 0 Td
(biosynthesis)Tj
5.3339 0 Td
(gene)Tj
2.1307 0 Td
(cluster)Tj
3.0284 0 Td
(sequences)Tj
4.3418 0 Td
(from)Tj
/F16 1 Tf
-26.6742 -1.1669 Td
[()48()12()4()-12()-1()4()5()5()3( )5( )]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 550.9984 cm
BT
/F8 1 Tf
1 TL
0.005 Tc
0 0 Td
(In)Tj
1.1281 0 Td
(this)Tj
1.7065 0 Td
(work,)Tj
2.5511 0 Td
(we)Tj
1.3437 0 Td
(set)Tj
1.3322 0 Td
(out)Tj
1.5761 0 Td
(to)Tj
1.0431 0 Td
(search)Tj
2.8176 0 Td
(both)Tj
2.0977 0 Td
(in)Tj
1.0488 0 Td
(the)Tj
1.4967 0 Td
(literature)Tj
3.9741 0 Td
(and)Tj
1.7575 0 Td
(the)Tj
1.4967 0 Td
(global)Tj
2.6759 0 Td
(sequence)Tj
3.9344 0 Td
(databases,)Tj
4.3143 0 Td
(to)Tj
-36.2945 -1.2982 Td
(identify)Tj
3.3561 0 Td
(gene)Tj
2.109 0 Td
(clusters)Tj
3.2938 0 Td
(for)Tj
1.406 0 Td
(biosynthesis)Tj
5.1987 0 Td
(of)Tj
1.0262 0 Td
(siderophores)Tj
5.4821 0 Td
(in)Tj
/F13 1 Tf
1.0432 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
(,)Tj
5.7089 0 Td
(and)Tj
1.7462 0 Td
(compile)Tj
3.4809 0 Td
(and)Tj
1.7461 0 Td
(visu-)Tj
-35.5972 -1.3039 Td
(alize)Tj
2.0466 0 Td
(the)Tj
1.4966 0 Td
(result)Tj
2.5002 0 Td
(in)Tj
1.0545 0 Td
(a)Tj
0.6633 0 Td
(simple)Tj
2.9083 0 Td
(and)Tj
1.7575 0 Td
(comprehensible)Tj
6.7124 0 Td
(manner.)Tj
3.6566 0 Td
(See)Tj
0.83 0.64 0.02 0 k
1.5704 0 Td
(Materials)Tj
4.0252 0 Td
(and)Tj
1.7575 0 Td
(methods)Tj
0 g
3.7473 0 Td
(for)Tj
-33.8964 -1.2983 Td
(details)Tj
2.8402 0 Td
(on)Tj
1.2926 0 Td
(search)Tj
2.8177 0 Td
(criteria.)Tj
0.83 0.64 0.02 0 k
3.3788 0 Td
(Fig)Tj
1.5081 0 Td
(1)Tj
0 g
0.7029 0 Td
(and)Tj
0.83 0.64 0.02 0 k
1.7575 0 Td
(Table)Tj
2.4888 0 Td
(1)Tj
0 g
0.703 0 Td
(summarize)Tj
4.7395 0 Td
(our)Tj
1.6498 0 Td
(findings.)Tj
3.804 0 Td
(Based)Tj
2.5909 0 Td
(on)Tj
1.2926 0 Td
(the)Tj
1.4966 0 Td
(literature)Tj
-33.063 -1.2983 Td
(we)Tj
1.3436 0 Td
(identified)Tj
4.1499 0 Td
(nine)Tj
2.0409 0 Td
(siderophore)Tj
5.125 0 Td
(biosynthesis)Tj
5.21 0 Td
(gene)Tj
2.1203 0 Td
(clusters)Tj
3.3052 0 Td
(responsible)Tj
4.8472 0 Td
(for)Tj
1.4173 0 Td
(producing)Tj
4.4561 0 Td
(aerobac-)Tj
-34.0155 -1.3039 Td
(tin,)Tj
1.593 0 Td
(bisucaberin,)Tj
5.193 0 Td
(vibrioferrin,)Tj
5.2044 0 Td
(vibriobactin,)Tj
5.4142 0 Td
(vanchrobactin,)Tj
6.3155 0 Td
(piscibactin,)Tj
4.8699 0 Td
(anguibactin,)Tj
5.2724 0 Td
(amphi-)Tj
-33.8624 -1.2982 Td
(enterobactin)Tj
5.3744 0 Td
(and)Tj
1.7575 0 Td
(vulnibactin.)Tj
0.83 0.64 0.02 0 k
5.0796 0 Td
(Fig)Tj
1.508 0 Td
(1)Tj
0 g
0.703 0 Td
(shows)Tj
2.7043 0 Td
(that)Tj
1.8141 0 Td
(genes)Tj
2.4888 0 Td
(belonging)Tj
4.2803 0 Td
(to)Tj
1.0432 0 Td
(the)Tj
1.4967 0 Td
(individual)Tj
4.3766 0 Td
(siderophore)Tj
-32.6265 -1.2983 Td
(biosynthetic)Tj
5.21 0 Td
(pathways)Tj
4.0025 0 Td
(are)Tj
1.474 0 Td
(typically)Tj
3.6453 0 Td
(found)Tj
2.6646 0 Td
(clustered)Tj
3.9061 0 Td
(bumper-to-bumper)Tj
9.0028 0 Td
(on)Tj
1.2926 0 Td
(the)Tj
1.4966 0 Td
(chromo-)Tj
-32.6945 -1.2983 Td
(some,)Tj
2.6021 0 Td
(or)Tj
1.1169 0 Td
(as)Tj
1.0318 0 Td
(in)Tj
/F13 1 Tf
1.0545 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1225 0 Td
[()16()13( )-8()12()4()4()4()16(\r)-9()12()]TJ
/F8 1 Tf
(,)Tj
5.4028 0 Td
(on)Tj
1.2926 0 Td
(a)Tj
0.6633 0 Td
(plasmid.)Tj
3.6907 0 Td
(Pathways)Tj
4.0421 0 Td
(for)Tj
1.4117 0 Td
(hydroxamate)Tj
5.5842 0 Td
(or)Tj
1.1168 0 Td
(carboxylate)Tj
4.8813 0 Td
(type)Tj
-35.0133 -1.3039 Td
(siderophores)Tj
5.4935 0 Td
(are)Tj
1.474 0 Td
(encoded)Tj
3.6623 0 Td
(by)Tj
1.2019 0 Td
(35)Tj
1.7178 0 Td
(genes,)Tj
2.7212 0 Td
(all)Tj
1.1679 0 Td
(encoded)Tj
3.668 0 Td
(on)Tj
1.2926 0 Td
(the)Tj
1.4967 0 Td
(same)Tj
2.296 0 Td
(DNA)Tj
2.4038 0 Td
(strand,)Tj
3.0444 0 Td
(whereas)Tj
3.5092 0 Td
(cate-)Tj
-35.1493 -1.2983 Td
(chol)Tj
1.9615 0 Td
(or)Tj
1.1112 0 Td
(mixed)Tj
2.7723 0 Td
(siderophores)Tj
5.4935 0 Td
(pathways)Tj
4.0025 0 Td
(are)Tj
1.474 0 Td
(typically)Tj
3.6453 0 Td
(encoded)Tj
3.6623 0 Td
(by)Tj
1.2019 0 Td
(611)Tj
2.1997 0 Td
(genes,)Tj
2.7212 0 Td
(including)Tj
4.1216 0 Td
(one)Tj
1.7234 0 Td
(or)Tj
-36.0904 -1.2982 Td
(more)Tj
2.3754 0 Td
(non-ribosomal)Tj
6.3098 0 Td
(peptide)Tj
3.2599 0 Td
(synthase)Tj
3.702 0 Td
(\(NRPS\))Tj
3.3449 0 Td
(gene\(s\),)Tj
3.4185 0 Td
(located)Tj
3.1465 0 Td
(on)Tj
1.2925 0 Td
(both)Tj
2.092 0 Td
(strands)Tj
3.1861 0 Td
(and)Tj
1.7575 0 Td
(not)Tj
1.6044 0 Td
(nec-)Tj
-35.4895 -1.3039 Td
(essarily)Tj
3.2087 0 Td
(in)Tj
1.0545 0 Td
(immediate)Tj
4.5808 0 Td
(proximity)Tj
4.2689 0 Td
(to)Tj
1.0432 0 Td
(each)Tj
2.0636 0 Td
(other.)Tj
2.6305 0 Td
(The)Tj
1.8085 0 Td
(synteny)Tj
3.3732 0 Td
(and)Tj
1.7575 0 Td
(general)Tj
3.1918 0 Td
(organization)Tj
5.3914 0 Td
(of)Tj
1.0319 0 Td
(the)Tj
-35.4045 -1.2983 Td
(latter)Tj
2.347 0 Td
(siderophore)Tj
5.1194 0 Td
(biosynthetic)Tj
5.21 0 Td
(gene)Tj
2.1203 0 Td
(cluster)Tj
2.931 0 Td
(types)Tj
2.3244 0 Td
(therefore)Tj
3.9345 0 Td
(appear)Tj
2.9707 0 Td
(more)Tj
2.3754 0 Td
(complex.)Tj
3.9231 0 Td
(Other)Tj
-33.2558 -1.2983 Td
(siderophores)Tj
5.4935 0 Td
(are)Tj
1.474 0 Td
(known)Tj
3.05 0 Td
(to)Tj
1.0432 0 Td
(be)Tj
1.1678 0 Td
(produced)Tj
4.1159 0 Td
(by)Tj
/F13 1 Tf
1.2019 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.4822 0 Td
(representatives.)Tj
6.565 0 Td
(However,)Tj
4.1499 0 Td
(even)Tj
-33.7434 -1.3039 Td
(though)Tj
3.1237 0 Td
(their)Tj
2.1543 0 Td
(structures)Tj
4.2746 0 Td
(are)Tj
1.4741 0 Td
(known,)Tj
3.2881 0 Td
(their)Tj
2.1487 0 Td
(biosynthesis)Tj
5.2157 0 Td
(gene)Tj
2.1146 0 Td
(clusters)Tj
3.3052 0 Td
(have)Tj
2.0976 0 Td
(not)Tj
1.5987 0 Td
(been)Tj
2.16 0 Td
(conclu-)Tj
-32.9553 -1.2982 Td
(sively)Tj
2.4774 0 Td
(identified)Tj
4.1499 0 Td
(in)Tj
/F13 1 Tf
1.0545 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
(,)Tj
5.7146 0 Td
(and)Tj
1.7575 0 Td
(they)Tj
1.9615 0 Td
(have)Tj
2.0977 0 Td
(therefore)Tj
3.9344 0 Td
(been)Tj
2.16 0 Td
(omitted)Tj
3.4242 0 Td
(from)Tj
0.83 0.64 0.02 0 k
2.2394 0 Td
(Fig)Tj
1.508 0 Td
(1)Tj
0 g
(.)Tj
0.9411 0 Td
(Examples)Tj
-33.4202 -1.2983 Td
(are)Tj
1.474 0 Td
(shown)Tj
2.8913 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0545 0 Td
(S1)Tj
1.1905 0 Td
(Fig)Tj
0 g
(,)Tj
1.7405 0 Td
(e.g.,)Tj
/F13 1 Tf
1.8311 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1282 0 Td
[()-36()12()15()-13()4()11()12()-4()]TJ
/F8 1 Tf
3.3505 0 Td
(and)Tj
/F13 1 Tf
1.7575 0 Td
[(\n)53()14()11(\r)-9()4()]TJ
2.7723 0 Td
[()18()10( )-8(\r)-9()10( )11()4()4()13()18(\r)-9()14()7()4()4()]TJ
/F8 1 Tf
6.7351 0 Td
(produce)Tj
3.5773 0 Td
(the)Tj
1.4966 0 Td
(catechol)Tj
3.5773 0 Td
(sidero-)Tj
-34.5767 -1.2983 Td
(phores)Tj
2.982 0 Td
(fluvibactin)Tj
4.5807 0 Td
(and)Tj
1.7575 0 Td
(nigribactin,)Tj
4.9493 0 Td
(respectively)Tj
4.9946 0 Td
([)Tj
0.83 0.64 0.02 0 k
(60)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(61)Tj
0 g
(].)Tj
3.3222 0 Td
(Also,)Tj
/F13 1 Tf
2.2903 0 Td
[(\n)53()14()11(\r)-9()4()]TJ
/F8 1 Tf
2.7723 0 Td
(isolates)Tj
3.1918 0 Td
(are)Tj
1.474 0 Td
(known)Tj
3.0501 0 Td
(to)Tj
-35.3648 -1.3039 Td
(produce)Tj
3.5773 0 Td
(trivanchrobactin)Tj
7.0468 0 Td
(\()Tj
/F13 1 Tf
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.4797 0 Td
[()7()16()15( )13()4()15()4()12()12()]TJ
/F8 1 Tf
4.2916 0 Td
(DS40M4;)Tj
4.0422 0 Td
([)Tj
0.83 0.64 0.02 0 k
(62)Tj
0 g
(]\),)Tj
2.4661 0 Td
(ochrobactins)Tj
5.5049 0 Td
(\()Tj
/F13 1 Tf
[(\n)]TJ
/F8 1 Tf
(.)Tj
1.474 0 Td
(sp.)Tj
1.3549 0 Td
(DS40M5;)Tj
4.0366 0 Td
([)Tj
0.83 0.64 0.02 0 k
(63)Tj
0 g
(]\))Tj
-35.2741 -1.2983 Td
(and)Tj
1.7574 0 Td
(desferroxamines)Tj
6.9449 0 Td
(\()Tj
/F13 1 Tf
[(\n)]TJ
/F8 1 Tf
(.)Tj
1.474 0 Td
(sp.)Tj
1.3549 0 Td
(BLI-41;)Tj
3.2655 0 Td
([)Tj
0.83 0.64 0.02 0 k
(64)Tj
0 g
(]\).)Tj
2.4718 0 Td
(In)Tj
/F13 1 Tf
1.1282 0 Td
[(\n)]TJ
/F8 1 Tf
(.)Tj
/F13 1 Tf
1.1225 0 Td
[()7()16()15( )13()4()15()4()12()12()]TJ
/F8 1 Tf
4.2973 0 Td
(DS40M4)Tj
3.8041 0 Td
(vanchrobactin)Tj
6.0831 0 Td
(and)Tj
1.7574 0 Td
(tri-)Tj
-35.4611 -1.2982 Td
(vanchrobactin)Tj
6.0831 0 Td
(are)Tj
1.474 0 Td
(produced)Tj
4.1158 0 Td
(from)Tj
2.2451 0 Td
(the)Tj
1.4967 0 Td
(same)Tj
2.2903 0 Td
(biosynthesis)Tj
5.2158 0 Td
(gene)Tj
2.1146 0 Td
(cluster,)Tj
3.1691 0 Td
(but)Tj
1.5817 0 Td
(in)Tj
1.0488 0 Td
(the)Tj
1.4967 0 Td
(distinguish-)Tj
-32.3317 -1.3039 Td
(ing)Tj
1.525 0 Td
(determinant)Tj
5.2837 0 Td
(is)Tj
0.8618 0 Td
(unknown[)Tj
0.83 0.64 0.02 0 k
(52)Tj
0 g
(].)Tj
-0.004 Tc
-6.4743 -1.2983 Td
(Next,)Tj
2.3697 0 Td
(we)Tj
1.3266 0 Td
(used)Tj
2.0636 0 Td
(the)Tj
1.4684 0 Td
(known)Tj
/F13 1 Tf
3.0047 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.3744 0 Td
(amino)Tj
2.795 0 Td
(acids)Tj
2.2337 0 Td
(sequences)Tj
4.2179 0 Td
(\(see)Tj
0.83 0.64 0.02 0 k
1.7688 0 Td
(Fig)Tj
1.4797 0 Td
(1A)Tj
1.3833 0 Td
(and)Tj
1.7291 0 Td
(1B)Tj
0 g
(\))Tj
1.6157 0 Td
(as)Tj
1.0148 0 Td
(que-)Tj
-35.0416 -1.2983 Td
(ries)Tj
1.644 0 Td
(in)Tj
1.0318 0 Td
(BLASTp)Tj
3.6284 0 Td
(searches)Tj
3.5432 0 Td
(to)Tj
1.0262 0 Td
(identify)Tj
3.2938 0 Td
(homologous)Tj
5.1987 0 Td
(siderophore)Tj
5.023 0 Td
(gene)Tj
2.0806 0 Td
(clusters)Tj
3.2315 0 Td
(in)Tj
1.0375 0 Td
(all)Tj
1.1451 0 Td
(available)Tj
/F13 1 Tf
-31.8838 -1.3039 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.3744 0 Td
(genomes)Tj
3.7701 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(non-redundant)Tj
6.3836 0 Td
(protein)Tj
3.1521 0 Td
(sequences)Tj
4.2236 0 Td
(database.)Tj
3.8607 0 Td
(Threshold)Tj
4.3257 0 Td
(values)Tj
-33.5903 -1.2983 Td
(were)Tj
2.1203 0 Td
(set)Tj
1.3039 0 Td
(to)Tj
/F15 1 Tf
0 Tc
1.0261 0 Td
()Tj
/F8 1 Tf
-0.004 Tc
(80%)Tj
2.6986 0 Td
(coverage)Tj
3.7247 0 Td
(and)Tj
/F15 1 Tf
0 Tc
1.7291 0 Td
()Tj
/F8 1 Tf
-0.004 Tc
(50%)Tj
2.6986 0 Td
(identity.)Tj
3.5319 0 Td
(Only)Tj
2.2167 0 Td
(complete)Tj
3.8778 0 Td
(siderophore)Tj
5.0229 0 Td
(biosynthesis)Tj
5.108 0 Td
(clus-)Tj
-35.0586 -1.2982 Td
(ters)Tj
1.6724 0 Td
(were)Tj
2.1203 0 Td
(kept)Tj
1.9559 0 Td
(\(i.e.,)Tj
1.9275 0 Td
(all)Tj
1.1509 0 Td
(genes)Tj
2.4378 0 Td
(needed)Tj
3.0954 0 Td
(for)Tj
1.3889 0 Td
(biosynthesis)Tj
5.1024 0 Td
(must)Tj
2.228 0 Td
(be)Tj
1.1508 0 Td
(present\).)Tj
3.7247 0 Td
(Our)Tj
1.8652 0 Td
(search)Tj
2.761 0 Td
(identified)Tj
4.0591 0 Td
(81)Tj
-36.6403 -1.3039 Td
(biosynthetic)Tj
5.1023 0 Td
(clusters)Tj
3.2315 0 Td
(in)Tj
1.0374 0 Td
(total,)Tj
2.228 0 Td
(distributed)Tj
4.5978 0 Td
(among)Tj
2.9934 0 Td
(45)Tj
1.1735 0 Td
(species)Tj
2.9934 0 Td
(and)Tj
1.7348 0 Td
(4)Tj
0.6916 0 Td
(genera,)Tj
3.1124 0 Td
(and)Tj
1.7292 0 Td
(16)Tj
1.1735 0 Td
(unclassified)Tj
/F13 1 Tf
-31.7988 -1.2983 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.3744 0 Td
(strains)Tj
2.863 0 Td
(\(i.e.,)Tj
/F13 1 Tf
1.9219 0 Td
[(\n)53()14()11(\r)-9()4()]TJ
/F8 1 Tf
2.7212 0 Td
(sp.\))Tj
1.6611 0 Td
(\(see)Tj
0.83 0.64 0.02 0 k
1.7688 0 Td
(S1)Tj
1.1735 0 Td
(Table)Tj
0 g
2.4435 0 Td
(for)Tj
1.3833 0 Td
(details\).)Tj
3.3448 0 Td
(The)Tj
1.7802 0 Td
(majority)Tj
3.6283 0 Td
(of)Tj
1.0148 0 Td
(species)Tj
2.999 0 Td
(can)Tj
-34.0778 -1.2983 Td
(potentially)Tj
4.4617 0 Td
(produce)Tj
3.5149 0 Td
(13)Tj
1.6894 0 Td
(of)Tj
1.0148 0 Td
(known)Tj
/F13 1 Tf
3.0047 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.3745 0 Td
(siderophores,)Tj
5.6126 0 Td
(with)Tj
1.9955 0 Td
(zero)Tj
1.9332 0 Td
(being)Tj
2.4322 0 Td
(the)Tj
1.474 0 Td
(minimum)Tj
-32.5075 -1.2982 Td
(and)Tj
1.7291 0 Td
(four)Tj
1.9162 0 Td
(the)Tj
1.4683 0 Td
(maximum.)Tj
-3.9174 -1.3039 Td
(Bacteria)Tj
3.4525 0 Td
(must)Tj
2.2281 0 Td
(encode)Tj
3.0727 0 Td
(and)Tj
1.7291 0 Td
(express)Tj
3.1465 0 Td
(siderophore)Tj
5.0229 0 Td
(receptors)Tj
3.9175 0 Td
(on)Tj
1.2756 0 Td
(their)Tj
2.1089 0 Td
(surface)Tj
3.0444 0 Td
(in)Tj
1.0375 0 Td
(order)Tj
2.4208 0 Td
(to)Tj
1.0261 0 Td
(take)Tj
-34.6788 -1.2983 Td
(up)Tj
1.2642 0 Td
(and)Tj
1.7291 0 Td
(utilize)Tj
2.6646 0 Td
(siderophore-Fe)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 317.6503 126.4251 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(3+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 327.7417 122.0031 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(complexes.)Tj
4.6317 0 Td
(It)Tj
0.8561 0 Td
(is)Tj
0.8504 0 Td
(therefore)Tj
3.8551 0 Td
(of)Tj
1.0148 0 Td
(equal)Tj
2.3584 0 Td
(importance)Tj
4.8302 0 Td
(to)Tj
1.0261 0 Td
(identify)Tj
3.2939 0 Td
(and)Tj
-35.4895 -1.2982 Td
(map)Tj
1.9899 0 Td
(the)Tj
1.4684 0 Td
(existence)Tj
3.8551 0 Td
(of)Tj
1.0148 0 Td
(siderophore-associated)Tj
9.4108 0 Td
(receptors.)Tj
4.1442 0 Td
(In)Tj
1.1055 0 Td
(a)Tj
0.6577 0 Td
(similar)Tj
2.982 0 Td
(approach)Tj
3.9572 0 Td
(as)Tj
1.0147 0 Td
(described)Tj
-31.6003 -1.3039 Td
(above,)Tj
2.7723 0 Td
(we)Tj
1.3266 0 Td
(identified)Tj
4.0592 0 Td
(and)Tj
1.7291 0 Td
(used)Tj
2.0579 0 Td
(siderophore)Tj
5.0229 0 Td
(receptor)Tj
3.5603 0 Td
(sequences)Tj
4.2179 0 Td
(in)Tj
1.0375 0 Td
(BLASTp)Tj
3.6226 0 Td
(searches.)Tj
3.7701 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(2)Tj
0 g
(\).)Tj
-35.96 -1.2983 Td
(The)Tj
1.7688 0 Td
(receptor)Tj
3.549 0 Td
(searches)Tj
3.5319 0 Td
(identified)Tj
4.0478 0 Td
(410)Tj
1.6384 0 Td
(siderophore)Tj
5.0173 0 Td
(receptors)Tj
3.9061 0 Td
(in)Tj
1.0261 0 Td
(89)Tj
1.1566 0 Td
(classified)Tj
/F13 1 Tf
3.8097 0 Td
[(\n)53()14()11(\r)-9()4()11()6()6()7()7()6()]TJ
/F8 1 Tf
5.3688 0 Td
(species)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 447.0803 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Sideropho)Tj
4.4716 0 Td
(re)Tj
1.0985 0 Td
(systems)Tj
3.8409 0 Td
(in)Tj
/F7 1 Tf
0.978 0 Td
(Vibrionac)Tj
4.0819 0 Td
(eae)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01918)Tj
4.089 0 Td
(60)Tj
0 g
2.0906 0 Td
(February)Tj
4.1599 0 Td
(14,)Tj
1.5874 0 Td
(2018)Tj
33.1585 0 Td
(6)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
251 0 obj
<>stream
endstream
endobj
252 0 obj
<>stream
endstream
endobj
253 0 obj
<>stream
endstream
endobj
254 0 obj
<>stream
endstream
endobj
255 0 obj
<>stream
endstream
endobj
256 0 obj
<>stream
endstream
endobj
257 0 obj
<>stream
endstream
endobj
258 0 obj
<>stream
endstream
endobj
259 0 obj
<>stream
endstream
endobj
260 0 obj
<>stream
endstream
endobj
261 0 obj
<>stream
endstream
endobj
262 0 obj
<>stream
endstream
endobj
263 0 obj
<>stream
endstream
endobj
264 0 obj
<>stream
endstream
endobj
265 0 obj
<>stream
BT
66.402 0 Td
(20)Tj
ET
Q
endstream
endobj
266 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 268 0 R/Contents 269 0 R/TrimBox[0 0 612 792]>>
endobj
267 0 obj
<>stream
xUڇ?(ETJB@RC%VF='9?<=kf֬gf~#" " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " ɂ_u={=aԩSɢejn+W,Pce˖իWFdA{OO<,F@j%
S/~HHt" " " " " " " " " " " ",̚5+}\pҥ
*ɢj>g-Lsȑ?~r9WN}Ht" " " " " " " " " " " ",lڴG11bD+۶m,ZF@#0j(d˖ԩSSNM&%(PرcXD@D@D@D@D@D@D@D@D@D@D@1ӧON)]4
ڱc,.q+uxH}-[vM7d.]nݺF9qRJXD@D@D@D@D@D@D@D@D@D@D@15=жm۬A'N̘1{VXqË@j"wy:7tgȑbŊ]7v!" " " " " " " " " " " "̙㔚8?_~Ν^m$ӧO7m)5O?c-_n<j[D@D@D@D@D@D@D@D@D@D@D@D lo7.^zN:U|y'g@}Hp#GtMLf̘||p.Bv-y"" " " " " " " " Q`02?}D@D@D u8|c(eʔq:NyI ~ekyp@-_1t@j 0dȩfMJ˶rn?".Gq:u.:w&@J"p醈7租~rLLf͚j
")9@HNa5k",_5kW^" " "Y;}ƬW9uTӦM*9k{]tEH֭C>(" " " " " " " " 8g̜9K`-{bBlu]vzNFܹ