Blar i Brage INN på forfatter "Hestad, Knut"
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Neuropsychological function in individuals with morbid obesity: A cross-sectional study
Sargénius; Lydersen, Stian; Hestad, Knut (Journal article; Peer reviewed, 2017)Background:Previous research has shown cognitive dysfunction to be present in a significant number ofindividuals with obesity. The objective of this study was to assess the neuropsychological profile of morbidlyobese ... -
Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis
Hestad, Knut; Engedal, Knut; Aukrust, Pål; Farup, Per Grønaas; Mollnes, Tom Eirik; Ueland, Thor; Whist, Jon Elling (Journal article; Peer reviewed, 2016)Introduction: Several reports indicate that inflammation may play a role in depression and demonstrate enhanced systemic levels of inflammatory mediators. We hypothesized that 44 patients with a diagnosis of depression ... -
The Peripheral Kynurenine Pathway and Psychosomatic Comorbidity in Subjects with Morbid Obesity Undergoing Bariatric Surgery
Farup, Per Grønaas; Hestad, Knut (Peer reviewed; Journal article, 2022)Background: The Kynurenine pathway (KP) is involved in various disorders, but little is known about the KP and psychosomatic complaints. The aim was to study the peripheral KP and psychosomatic comorbidity in subjects with ... -
PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress.
Toft, Helge Prytz; Bramness, Jørgen Gustav; Lien, Lars; Abebe, Dawit Shawel; Wampold, Bruce E.; Tilden, Terje; Hestad, Knut; Neupane, Sudan Prasad (Peer reviewed; Journal article, 2018)Background: A reciprocal relationship between activated innate immune system and changes in mood and behavior has been established. There is still a paucity of knowledge on how the immune system responds during psychiatric ... -
Relationships of sources of meaning and resilience with meaningfulness and satisfaction with life: A population-based study of Norwegians in late adulthood
Sørensen, Torgeir; Hestad, Knut; Grov, Ellen Karine (Peer reviewed; Journal article, 2021)Abstract Health-promoting initiatives incorporating meaning-making to enhance the well-being of people in late adulthood are important, particularly as the number of older people is increasing. Resilience and sources of ... -
The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases
Hestad, Knut; Alexander, Jan; Rootwelt, Helge; Aaseth, Jan (Peer reviewed; Journal article, 2022-07-18)Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several ... -
The effect of ApoE e4 on blood pressure in patients with and without depression
Hestad, Knut; Engedal, Knut; Whist, Jon Elling; Farup, Per Grønaas (Journal article; Peer reviewed, 2016)Introduction: Depression is considered an independent risk factor for hypertension, particularly for people with recurrent episodes or a long history of depression. Another risk factor for cardiovascular disease is the ... -
The effect of blood pressure on cognitive performance. An 8-year follow-up of the Tromsø Study, comprising people aged 45–74 Years
Hestad, Knut; Engedal, Knut; Schirmer, Henrik; Strand, Bjørn Heine (Peer reviewed; Journal article, 2020)Background: The relationship between blood pressure (BP) and cognition is complex were age appears to be an intervening variable. High and low BP have been associated with cognitive deficits as part of the aging process, ... -
The Relationships among Tryptophan, Kynurenine, Indoleamine 2,3-Dioxygenase, Depression, and Neuropsychological Performance
Hestad, Knut; Engedal, Knut; Whist, Jon Elling; Farup, Per Grønaas (Peer reviewed; Journal article, 2017)It has been suggested that the metabolic enzyme indoleamine 2,3-dioxygenase (IDO) is a biological mediator of inflammation related to the psychopathology of depression, with a Kynurenine (KYN) increase in the Tryptophan ... -
Treatment strategies in Alzheimer’s disease: a review with focus on selenium supplementation
Aaseth, Jan; Alexander, Jan; Bjørklund, Geir; Hestad, Knut; Dusek, Petr; Roos, Per M.; Alehagen, Urban (Journal article; Peer reviewed, 2016)Alzheimer’s disease (AD) is a neurodegenerative disorder presenting one of the biggest healthcare challenges in developed countries. No effective treatment exists. In recent years the main focus of AD research has been on ... -
Trust in Crisis. Conspiracy Mentality, Lack of Trust and Religiosity Predicted Conspiracy Beliefs about COVID-19 in a Norwegian Sample.
Dyrendal, Asbjørn; Hestad, Knut (Peer reviewed; Journal article, 2021)Crises are associated with a search for meaning and security. In recent years, they have also been associated with increased attention to conspiracy theories. Such theories about COVID-19 have been many. We have looked at ... -
Visual-Constructional Ability in Individuals with Severe Obesity: Rey Complex Figure Test Accuracy and the Q-Score
Sargenius, Hanna; Bylsma, Frederick; Lydersen, Stian; Hestad, Knut (Peer reviewed; Journal article, 2017)The aims of this study were to investigate visual-construction and organizational strategy among individuals with severe obesity, as measured by the Rey Complex Figure Test (RCFT), and to examine the validity of the Q-score ...