• Body mass is associated with hibernation length, body temperature, and heart rate in free-ranging brown bears 

      Evans, Alina; Fuchs, Boris; Singh, Navinder; Thiel, Alexandra; Giroud, Sylvain; Blanc, Stephane; Laske, Timothy G.; Frobert, Ole; Friebe, Andrea; Swenson, Jon; Arnemo, Jon Martin (Peer reviewed; Journal article, 2023)
      Background Despite centuries of research, debate remains on the scaling of metabolic rate to mass especially for intraspecific cases. The high variation of body mass within brown bears presents a unique opportunity to ...
    • The cost of research: Lasting effects of capture, surgery and muscle biopsy on brown bear (Ursus arctos) movement and physiology 

      Thiel, Alexandra; Hertel, Anne Gabriela; Giroud, Sylvain; Friebe, Andrea; Fuchs, Boris; Kindberg, Jonas; Græsli, Anne Randi; Arnemo, Jon Martin; Evans, Alina (Peer reviewed; Journal article, 2023)
      Animal models are a key component of translational medicine, helping transfer scientific findings into practical applications for human health. A fundamental principle of research ethics involves weighing the benefits of ...
    • Hibernating brown bears are protected against atherogenic dyslipidemia 

      Giroud, Sylvain; Chery, Isabelle; Arrivé, Mathilde; Prost, Michel; Zumsteg, Julie; Heintz, Dimitri; Evans, Alina; Gauquelin-Koch, Guillemette; Arnemo, Jon Martin; Swenson, Jon E.; Lefai, Etienne; Bertile, Fabrice; Simon, Chantal; Blanc, Stéphane (Peer reviewed; Journal article, 2021)
      To investigate mechanisms by which hibernators avoid atherogenic hyperlipidemia during hibernation, we assessed lipoprotein and cholesterol metabolisms of free-ranging Scandinavian brown bears (Ursus arctos). In winter- ...
    • Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears 

      Ebert, Thomas; Painer, Johanna; Bergman, Peter; Qureshi, Abdul Rashid; Giroud, Sylvain; Stalder, Gabrielle; Kublickiene, Karolina; Göritz, Frank; Vetter, Sebastian G.; Bieber, Claudia; Fröbert, Ole; Arnemo, Jon Martin; Zedrosser, Andreas; Redtenbacher, Irene; Shiels, Paul; Johnson, Richard J.; Stenvinkel, Peter (Peer reviewed; Journal article, 2020)
      Experimental studies suggest involvement of trimethylamine N-oxide (TMAO) in the aetiology of cardiometabolic diseases and chronic kidney disease (CKD), in part via metabolism of ingested food. Using a comparative biomimetic ...
    • Lipidomics reveals seasonal shifts in a large-bodied hibernator, the brown bear 

      Giroud, Sylvain; Chery, Isabelle; Bertile, Fabrice; Bertrand-Michel, Justine; Tascher, Georg; Gauquelin-Koch, Guillemette; Arnemo, Jon Martin; Swenson, Jon; Singh, Navinder; Lefai, Etienne; Evans, Alina L.; Simon, Chantal; Blanc, Stéphane (Peer reviewed; Journal article, 2019)
    • Seasonal changes in eicosanoid metabolism in the brown bear 

      Giroud, Sylvain; Evans, Alina L.; Chery, Isabelle; Bertile, Fabrice; Tascher, Georg; Bertrand-Michel, Justine; Gauquelin-Koch, Guillemette; Arnemo, Jon Martin; Swenson, Jon; Lefai, Etienne; Blanc, Stéphane; Simon, Chantal (Peer reviewed; Journal article, 2018)
    • Seasonality in Biological Rhythms in Scandinavian brown Bears 

      Thiel, Alexandra; Giroud, Sylvain; Hertel, Anne Gabriela; Friebe, Andrea; Devineau, Olivier; Fuchs, Boris; Blanc, Stephane; Støen, Ole-Gunnar; Laske, Timothy G.; Arnemo, Jon Martin; Evans, Alina (Peer reviewed; Journal article, 2022)
      Biological rhythms, such as rhythms in activity and body temperature, are usually highly synchronized and entrained by environmental conditions, such as photoperiod. However, how the expression of these rhythms changes ...