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dc.contributor.authorFröbert, Ole
dc.contributor.authorChristensen, Kjeld
dc.contributor.authorFahlman, Åsa
dc.contributor.authorBrunberg, Sven
dc.contributor.authorJosefsson, Johan
dc.contributor.authorSärndahl, Eva
dc.contributor.authorSwenson, Jon E.
dc.contributor.authorArnemo, Jon Martin
dc.date.accessioned2011-02-10T09:34:13Z
dc.date.available2011-02-10T09:34:13Z
dc.date.issued2010
dc.identifier.citationFröbert et al. (2010). Platelet function in brown bear (Ursus arctos) compared to man. Trombosis Journal 8(11)en_US
dc.identifier.issn1477-9560
dc.identifier.urihttp://hdl.handle.net/11250/134324
dc.descriptionThe article can also be located here: http://www.thrombosisjournal.com/content/8/1/11en_US
dc.description.abstractBackground: Information on hemostasis and platelet function in brown bear (Ursus arctos) is of importance for understanding the physiological, protective changes during hibernation. Objective: The study objective was to document platelet activity values in brown bears shortly after leaving the den and compare them to platelet function in healthy humans. Methods: Blood was drawn from immobilized wild brown bears 7-10 days after leaving the den in mid April. Blood samples from healthy human adults before and after clopidogrel and acetylsalicylic acid administration served as control. We analyzed blood samples by standard blood testing and platelet aggregation was quantified after stimulation with various agonists using multiple electrode aggregometry within 3 hours of sampling. Results: Blood samples were collected from 6 bears (3 females) between 1 and 16 years old and from 10 healthy humans. Results of adenosine diphosphate, aspirin, and thrombin receptor activating peptide tests in bears were all half or less of those in humans. Platelet and white blood cell counts did not differ between species but brown bears had more and smaller red blood cells compared with humans. Conclusion: Using three different tests, we conclude that platelet function is lower in brown bears compared to humans. Our findings represent the first descriptive study on platelet function in brown bears and may contribute to explain how bears can endure denning without obvious thrombus building. However, the possibility that our findings reflect test-dependent and not true biological variations in platelet reactivity needs further studies.en_US
dc.language.isoengen_US
dc.publisherThrombosis Journalen_US
dc.relation.urihttp://www.thrombosisjournal.com/content/8/1/11
dc.subjectbrunbjørneren_US
dc.subjectUrsus arctosen_US
dc.subjectplatelet functionen_US
dc.subjectblodplateen_US
dc.titlePlatelet function in brown bear (Ursus arctos) compared to manen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.subject.nsiVDP::Mathematics and natural science: 400::Zoology and botany: 480en_US


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