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dc.contributor.authorNeupane, Sudan Prasad
dc.contributor.authorSkulberg, Andreas
dc.contributor.authorSkulberg, Knut Ragnvald
dc.contributor.authorAass, Hans Christian
dc.contributor.authorBramness, Jørgen Gustav
dc.descriptionThis is an Open Access article licensed under the Creative Commons Attribution License 3.0 (CC BY 3.0) and originally published in Mediators of Inflammation. You can access the article by following this link:
dc.descriptionDette er en vitenskapelig, fagfellevurdert artikkel som opprinnelig ble publisert i Mediators of Inflammation. Artikkelen er publisert under lisensen Creative Commons Attribution License 3.0 (CC BY 3.0). Du kan også få tilgang til artikkelen ved å følge denne lenken:
dc.description.abstractAlcohol is a known modulator of the innate immune system. Owing to the absence of human studies, alcohol’s effect on circulating cytokine profile remains unclear. We investigated the effect of acute high dose alcohol consumption on systemic cytokine release. After an overnight fasting, alcohol-experienced healthy male volunteers () aged 25–45 years were given oral ethanol in the form of vodka (4.28 mL/kg) which they drank over a period of 30 minutes reaching peak blood alcohol concentration of 0.12% (SD 0.028). Blood samples were obtained prior to alcohol intake as well as 2, 7, and 12 hours thereafter. Serum levels of the inflammatory cytokines IL-1β, IL-1Ra, IL-6, IL-10, IL-17, IFN-γ, MCP-1, and TNF-α were determined by the multibead-based assay. Baseline cytokine levels were not related to BMI, hepatic parameters, electrolytes, glucose, or morning cortisol levels. Within 2 hours of alcohol intake, levels of IL-1Ra were elevated and remained so throughout the assessment period ( for trend = 0.015). In contrast, the levels of the chemokine MCP-1 dropped acutely followed by steadily increasing levels during the observation period (). The impact of sustained elevated levels of MCP-1 even after the clearance of blood alcohol content deserves attention.nb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleCytokine Changes following Acute Ethanol Intoxication in Healthy Men: A Crossover Studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalMediators of Inflammationnb_NO

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal