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dc.contributor.authorFagernes, Cathrine Elisabeth
dc.contributor.authorStensløkken, Kåre-Olav
dc.contributor.authorKjendseth, Åsmund Røhr
dc.contributor.authorBerenbrink, Michael
dc.contributor.authorEllefsen, Stian
dc.contributor.authorNilsson, Göran Erik
dc.date.accessioned2018-01-08T12:35:43Z
dc.date.available2018-01-08T12:35:43Z
dc.date.created2017-08-14T13:18:29Z
dc.date.issued2017
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11250/2476215
dc.description.abstractWithout oxygen, most vertebrates die within minutes as they cannot meet cellular energy demands with anaerobic metabolism. However, fish of the genus Carassius (crucian carp and goldfish) have evolved a specialized metabolic system that allows them to survive prolonged periods without oxygen by producing ethanol as their metabolic end-product. Here we show that this has been made possible by the evolution of a pyruvate decarboxylase, analogous to that in brewer’s yeast and the first described in vertebrates, in addition to a specialized alcohol dehydrogenase. Whole-genome duplication events have provided additional gene copies of the pyruvate dehydrogenase multienzyme complex that have evolved into a pyruvate decarboxylase, while other copies retained the essential function of the parent enzymes. We reveal the key molecular substitution in duplicated pyruvate dehydrogenase genes that underpins one of the most extreme hypoxic survival strategies among vertebrates and that is highly deleterious in humans.nb_NO
dc.language.isoengnb_NO
dc.titleExtreme anoxia tolerance in crucian carp and goldfish through neofunctionalization of duplicated genes creating a new ethanol- producing pyruvate decarboxylase pathwaynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.journalScientific Reportsnb_NO
dc.source.issue7nb_NO
dc.identifier.doi10.1038/s41598-017-07385-4
dc.identifier.cristin1486117
cristin.unitcode209,99,4,3
cristin.unitnameIdrett
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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