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dc.contributor.authorAaseth, Jan
dc.contributor.authorDusek, Petr
dc.contributor.authorRoos, Per M.
dc.date.accessioned2019-03-26T08:45:40Z
dc.date.available2019-03-26T08:45:40Z
dc.date.created2018-08-27T10:32:12Z
dc.date.issued2018
dc.identifier.citationBiometals. 2018, 737-747.
dc.identifier.issn0966-0844
dc.identifier.urihttp://hdl.handle.net/11250/2591728
dc.description.abstractEnvironmental influences affecting genetically susceptible individuals seem to contribute significantly to the development of Parkinson’s disease (PD). Xenobiotic exposure including transitional metal deposition into vulnerable CNS regions appears to interact with PD genes. Such exposure together with mitochondrial dysfunction evokes a destructive cascade of biochemical events, including oxidative stress and degeneration of the sensitive dopamine (DA) production system in the basal ganglia. Recent research indicates that the substantia nigra degeneration can be decelerated by treatment with iron binding compounds such as deferiprone. Interestingly compounds known to decrease PD risk including caffeine, niacin, nicotine and salbutamol also possess iron binding properties. Adequate function of antioxidative mechanisms in the vulnerable brain cells can be restored by acetylcysteine supplementation to normalize intracellular glutathione activity. Other preventive measures to reduce deterioration of dopaminergic neurons may involve life-style changes such as intake of natural antioxidants and physical exercise. Further research is recommended to identify therapeutic targets of the proposed interventions, in particular protection of the DA biosynthesis by oxygen radical scavengers and iron binding agents.
dc.description.abstractPrevention of progression in Parkinson’s disease
dc.language.isoeng
dc.titlePrevention of progression in Parkinson’s disease
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.source.pagenumber737-747
dc.source.journalBiometals
dc.identifier.doi10.1007/s10534-018-0131-5
dc.identifier.cristin1604584
cristin.unitcode209,4,1,0
cristin.unitnameInstitutt for sykepleiefag
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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