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dc.contributor.authorEbert, Thomas
dc.contributor.authorPainer, Johanna
dc.contributor.authorBergman, Peter
dc.contributor.authorQureshi, Abdul Rashid
dc.contributor.authorGiroud, Sylvain
dc.contributor.authorStalder, Gabrielle
dc.contributor.authorKublickiene, Karolina
dc.contributor.authorGöritz, Frank
dc.contributor.authorVetter, Sebastian G.
dc.contributor.authorBieber, Claudia
dc.contributor.authorFröbert, Ole
dc.contributor.authorArnemo, Jon Martin
dc.contributor.authorZedrosser, Andreas
dc.contributor.authorRedtenbacher, Irene
dc.contributor.authorShiels, Paul
dc.contributor.authorJohnson, Richard J.
dc.contributor.authorStenvinkel, Peter
dc.date.accessioned2021-06-28T14:14:16Z
dc.date.available2021-06-28T14:14:16Z
dc.date.created2021-01-20T16:32:31Z
dc.date.issued2020
dc.identifier.citationScientific Reports. 2020, 10, 20323 .en_US
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/11250/2761726
dc.description.abstractExperimental studies suggest involvement of trimethylamine N-oxide (TMAO) in the aetiology of cardiometabolic diseases and chronic kidney disease (CKD), in part via metabolism of ingested food. Using a comparative biomimetic approach, we have investigated circulating levels of the gut metabolites betaine, choline, and TMAO in human CKD, across animal species as well as during hibernation in two animal species. Betaine, choline, and TMAO levels were associated with renal function in humans and differed significantly across animal species. Free-ranging brown bears showed a distinct regulation pattern with an increase in betaine (422%) and choline (18%) levels during hibernation, but exhibited undetectable levels of TMAO. Free-ranging brown bears had higher betaine, lower choline, and undetectable TMAO levels compared to captive brown bears. Endogenously produced betaine may protect bears and garden dormice during the vulnerable hibernating period. Carnivorous eating habits are linked to TMAO levels in the animal kingdom. Captivity may alter the microbiota and cause a subsequent increase of TMAO production. Since free-ranging bears seems to turn on a metabolic switch that shunts choline to generate betaine instead of TMAO, characterisation and understanding of such an adaptive switch could hold clues for novel treatment options in burden of lifestyle diseases, such as CKD.en_US
dc.language.isoengen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectbrown bearen_US
dc.subjectfree-rangingen_US
dc.subjectcaptivityen_US
dc.subjecthibernationen_US
dc.subjecttrimetylamine N‑oxideen_US
dc.subjectmetabolismen_US
dc.titleInsights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bearsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480en_US
dc.source.volume10en_US
dc.source.journalScientific Reportsen_US
dc.identifier.doi10.1038/s41598-020-76346-1
dc.identifier.cristin1875833
dc.source.articlenumber20323en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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