Browsing Brage INN by Author "Aaseth, Jan"
Now showing items 21-38 of 38
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Lead poisoning among opium users in Iran: an emerging health hazard
Hayatbakhsh, Mohammad Mahdi; Oghabian, Zohreh; Conlon, Elvira; Nakhaee, Samaneh; Amirabadizadeh, Ali Reza; Zahedi, Mohammad Javad; Moghadam, Sodief Darvish; Ahmadi, Bighan; Soroush, Somayeh; Aaseth, Jan; Mehrpour, Omid (Peer reviewed; Journal article, 2017)Background Lead (Pb) poisoning among people using opium has been an increasing problem in Iran. The present study highlights the clinical effects of lead toxicity associated with opium use in Iran, Kerman province. Methods ... -
Levels of sP-selectin and hs-CRP Decrease with Dietary Intervention with Selenium and Coenzyme Q10 Combined: A Secondary Analysis of a Randomized Clinical Trial
Alehagen, Urban; Lindahl, Tomas L.; Aaseth, Jan; Svensson, Erland; Johansson, Peter (Journal article; Peer reviewed, 2015-09-16)Background/Objectives Inflammation and oxidative stress are central in many disease states. The major anti-oxidative enzymes contain selenium. The selenium intake in Europe is low, and supplementation with selenium and ... -
Mercury exposure and its effects on fertility and pregnancy outcome
Bjørklund, Geir; Chirumbolo, Salvatore; Dadar, Maryam; Pivina, Lyudmila; Lindh, Ulf; Butnariu, Monica; Aaseth, Jan (Peer reviewed; Journal article, 2019)Mercury (Hg), a highly toxic environmental pollutant, shows harmfulness which still represents a big concern for human health, including hazards to fertility and pregnancy outcome. Research has shown that Hg could induce ... -
Postoperative Osteoporosis in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy
Aaseth, Jan; Alexander, Jan (Peer reviewed; Journal article, 2023)Obesity has become a worldwide epidemic accompanied by adverse health effects. The limited efficiency of traditional weight reduction regimens has led to a substantial increase in the use of bariatric surgery. Today, sleeve ... -
Prevention of progression in Parkinson’s disease
Aaseth, Jan; Dusek, Petr; Roos, Per M. (Peer reviewed; Journal article, 2018)Environmental influences affecting genetically susceptible individuals seem to contribute significantly to the development of Parkinson’s disease (PD). Xenobiotic exposure including transitional metal deposition into ... -
Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized DoubleBlind Placebo-Controlled Trial in Elderly Citizens
Alehagen, Urban; Aaseth, Jan; Johansson, Peter (Journal article; Peer reviewed, 2015)BACKGROUND: Selenium and coenzyme Q10 are important antioxidants in the body. As the intake of selenium is low in Europe, and the endogenous production of coenzyme Q10 decreases as age increases, an intervention trial using ... -
A review on coordination properties of thiol-containing chelating agents towards mercury, cadmium, and lead
Bjørklund, Geir; Crisponi, Guido; Nurchi, Valeria Marina; Cappai, Rosita; Djordjevic, Aleksandra Buha; Aaseth, Jan (Peer reviewed; Journal article, 2019)Abstract: The present article reviews the clinical use of thiol-based metal chelators in intoxications and overexposure with mercury (Hg), cadmium (Cd), and lead (Pb). Currently, very few commercially available pharmaceuticals ... -
The Role of Persistent Organic Pollutants in Obesity: A Review of Laboratory and Epidemiological Studies
Aaseth, Jan; Javorac, Dragana; Djordjevic, Aleksandra Buha; Bulat, Zorica; Skalny, Anatoly V.; Zaitseva, Irina P.; Aschner, Michael; Tinkov, Alexey A. (Peer reviewed; Journal article, 2022)Persistent organic pollutants (POPs) are considered as potential obesogens that may affect adipose tissue development and functioning, thus promoting obesity. However, various POPs may have different mechanisms of action. ... -
The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases
Hestad, Knut; Alexander, Jan; Rootwelt, Helge; Aaseth, Jan (Peer reviewed; Journal article, 2022-07-18)Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several ... -
Selenium and coenzyme Q<inf>10</inf> improve the systemic redox status while reducing cardiovascular mortality in elderly population-based individuals
Dunning, Belinda J.; Bourgonje, Arno R.; Bulthuis, Marian L.C.; Alexander, Jan; Aaseth, Jan; Larsson, Anders; van Goor, Harry; Alehagen, Urban (Peer reviewed; Journal article, 2023)Background Serum sulfhydryl groups (R–SH, free thiols) reflect the systemic redox status in health and disease, and may be amenable to therapeutic modulation. Since R–SH are readily oxidized by reactive species, oxidative ... -
Selenium and Coenzyme Q<inf>10</inf> Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality-Sub-Study of a Randomized Clinical Trial
Opstad, Trine Baur; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Seljeflot, Ingebjørg; Alehagen, Urban (Peer reviewed; Journal article, 2022)Short telomeres have been associated with ageing and cardiovascular disease. The influence on leukocyte telomere length (LTL) of long-term intervention with combined selenium and coenzyme Q10 is unknown. Our aim was to ... -
Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Wågsäter, Dick (Journal article; Peer reviewed, 2017)Background Selenium and coenzyme Q10 is essential for important cellular functions. A low selenium intake is reported from many European countries, and the endogenous coenzyme Q10 production is decreasing in the body with ... -
Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly
Alehagen, Urban; Aaseth, Jan; Alexander, Jan; Johansson, Peter (Peer reviewed; Journal article, 2018)Selenium and coenzyme Q10 are both necessary for optimal cell function in the body. The intake of selenium is low in Europe, and the endogenous production of coenzyme Q10 decreases as age increases. Therefore, an intervention ... -
Supplementation with Selenium and Coenzyme Q10 Reduces Cardiovascular Mortality in Elderly with Low Selenium Status: A Secondary Analysis of a Randomised Clinical Trial
Alehagen, Urban; Alexander, Jan; Aaseth, Jan (Journal article; Peer reviewed, 2016)Background Selenium is needed by all living cells in order to ensure the optimal function of several enzyme systems. However, the selenium content in the soil in Europe is generally low. Previous reports indicate that a ... -
Supplementation with selenium and coenzyme Q<inf>10</inf> in an elderly Swedish population low in selenium — positive effects on thyroid hormones, cardiovascular mortality, and quality of life
Alehagen, Urban; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Opstad, Trine Baur (Peer reviewed; Journal article, 2024)Background Selenium-dependent deiodinases play a central role in thyroid hormone regulation and metabolism. In many European countries, insufficient selenium intake may consequently lead to adverse effects on thyroid ... -
Toxic and Essential Metals in Human Health and Disease 2021
Aaseth, Jan (Others, 2022) -
Treatment strategies in Alzheimer’s disease: a review with focus on selenium supplementation
Aaseth, Jan; Alexander, Jan; Bjørklund, Geir; Hestad, Knut; Dusek, Petr; Roos, Per M.; Alehagen, Urban (Journal article; Peer reviewed, 2016)Alzheimer’s disease (AD) is a neurodegenerative disorder presenting one of the biggest healthcare challenges in developed countries. No effective treatment exists. In recent years the main focus of AD research has been on ... -
Vitamin K and Calcium Chelation in Vascular Health
Aaseth, Jan; Alehagen, Urban; Opstad, Trine Baur; Alexander, Jan (Peer reviewed; Journal article, 2023)The observation that the extent of artery calcification correlates with the degree of atherosclerosis was the background for the alternative treatment of cardiovascular disease with chelator ethylenediamine tetraacetate ...