Browsing Brage INN by Author "Alehagen, Urban"
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Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: a subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK
Alehagen, Urban; Alexander, Jan; Aaseth, Jan; Larsson, Anders (Journal article; Peer reviewed, 2019)Background Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons ... -
Diets and drugs for weight loss and health in obesity - An update
Aaseth, Jan Olav; Ellefsen, Stian; Alehagen, Urban; Sundfør, Tine Mejlbo; Alexander, Jan (Peer reviewed; Journal article, 2021)Numerous combinations of diets and pharmacological agents, including lifestyle changes, have been launched to treat obesity. There are still ambiguities regarding the efficacies of different approaches despite many clinical ... -
Diets and drugs for weight loss and health in obesity – An update
Aaseth, Jan; Ellefsen, Stian; Alehagen, Urban; Sundfør, Tine M.; Alexander, Jan (Peer reviewed; Journal article, 2021)Numerous combinations of diets and pharmacological agents, including lifestyle changes, have been launched to treat obesity. There are still ambiguities regarding the efficacies of different approaches despite many clinical ... -
Effects of an Intervention with Selenium and Coenzyme Q<inf>10</inf> on Five Selected Age-Related Biomarkers in Elderly Swedes Low in Selenium: Results That Point to an Anti-Ageing Effect—A Sub-Analysis of a Previous Prospective Double-Blind Placebo-Controlled Randomised Clinical Trial
Alehagen, Urban; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Svensson, Erland; Opstad, Trine Baur (Peer reviewed; Journal article, 2023)Background: Ageing is associated with cardiovascular disease (CVD). As no single biomarker reflects the full ageing process, we aimed to investigate five CVD- and age-related markers and the effects of selenium and coenzyme ... -
Impact of selenium on biomarkers and clinical aspects related to ageing. A review
Alehagen, Urban; Opstad, Trine B.; Alexander, Jan; Larsson, Anders; Aaseth, Jan (Peer reviewed; Journal article, 2021)Selenium (Se) is an essential dietary trace element that plays an important role in the prevention of inflammation, cardiovascular diseases, infections, and cancer. Selenoproteins contain selenocysteine in the active center ... -
Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden
Alehagen, Urban; Johansson, Peter; Svensson, Erland; Aaseth, Jan; Alexander, Jan (Peer reviewed; Journal article, 2022)Purpose Selenium and coenzyme Q10 have synergistic antioxidant functions. In a four-year supplemental trial in elderly Swedes with a low selenium status, we found improved cardiac function, less cardiac wall tension and ... -
Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10. A prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Brismar, Kerstin (Peer reviewed; Journal article, 2017) -
Increased SIRT1 Concentration Following Four Years of Selenium and Q<inf>10</inf> Intervention Associated with Reduced Cardiovascular Mortality at 10-Year Follow-Up—Sub-Study of a Previous Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial
Opstad, Trine Baur; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Seljeflot, Ingebjørg; Alehagen, Urban (Peer reviewed; Journal article, 2023)Background: Selenium and coenzyme Q10 (SeQ10) possess antioxidant and anti-inflammatory properties, potentially mediated via Sirtuin1 (SIRT1). We aimed to investigate the influence of a SeQ10 intervention on SIRT1 ... -
Levels of sP-selectin and hs-CRP Decrease with Dietary Intervention with Selenium and Coenzyme Q10 Combined: A Secondary Analysis of a Randomized Clinical Trial
Alehagen, Urban; Lindahl, Tomas L.; Aaseth, Jan; Svensson, Erland; Johansson, Peter (Journal article; Peer reviewed, 2015-09-16)Background/Objectives Inflammation and oxidative stress are central in many disease states. The major anti-oxidative enzymes contain selenium. The selenium intake in Europe is low, and supplementation with selenium and ... -
Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized DoubleBlind Placebo-Controlled Trial in Elderly Citizens
Alehagen, Urban; Aaseth, Jan; Johansson, Peter (Journal article; Peer reviewed, 2015)BACKGROUND: Selenium and coenzyme Q10 are important antioxidants in the body. As the intake of selenium is low in Europe, and the endogenous production of coenzyme Q10 decreases as age increases, an intervention trial using ... -
Selenium and coenzyme Q<inf>10</inf> improve the systemic redox status while reducing cardiovascular mortality in elderly population-based individuals
Dunning, Belinda J.; Bourgonje, Arno R.; Bulthuis, Marian L.C.; Alexander, Jan; Aaseth, Jan; Larsson, Anders; van Goor, Harry; Alehagen, Urban (Peer reviewed; Journal article, 2023)Background Serum sulfhydryl groups (R–SH, free thiols) reflect the systemic redox status in health and disease, and may be amenable to therapeutic modulation. Since R–SH are readily oxidized by reactive species, oxidative ... -
Selenium and Coenzyme Q<inf>10</inf> Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality-Sub-Study of a Randomized Clinical Trial
Opstad, Trine Baur; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Seljeflot, Ingebjørg; Alehagen, Urban (Peer reviewed; Journal article, 2022)Short telomeres have been associated with ageing and cardiovascular disease. The influence on leukocyte telomere length (LTL) of long-term intervention with combined selenium and coenzyme Q10 is unknown. Our aim was to ... -
Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Wågsäter, Dick (Journal article; Peer reviewed, 2017)Background Selenium and coenzyme Q10 is essential for important cellular functions. A low selenium intake is reported from many European countries, and the endogenous coenzyme Q10 production is decreasing in the body with ... -
Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly
Alehagen, Urban; Aaseth, Jan; Alexander, Jan; Johansson, Peter (Peer reviewed; Journal article, 2018)Selenium and coenzyme Q10 are both necessary for optimal cell function in the body. The intake of selenium is low in Europe, and the endogenous production of coenzyme Q10 decreases as age increases. Therefore, an intervention ... -
Supplementation with Selenium and Coenzyme Q10 Reduces Cardiovascular Mortality in Elderly with Low Selenium Status: A Secondary Analysis of a Randomised Clinical Trial
Alehagen, Urban; Alexander, Jan; Aaseth, Jan (Journal article; Peer reviewed, 2016)Background Selenium is needed by all living cells in order to ensure the optimal function of several enzyme systems. However, the selenium content in the soil in Europe is generally low. Previous reports indicate that a ... -
Treatment strategies in Alzheimer’s disease: a review with focus on selenium supplementation
Aaseth, Jan; Alexander, Jan; Bjørklund, Geir; Hestad, Knut; Dusek, Petr; Roos, Per M.; Alehagen, Urban (Journal article; Peer reviewed, 2016)Alzheimer’s disease (AD) is a neurodegenerative disorder presenting one of the biggest healthcare challenges in developed countries. No effective treatment exists. In recent years the main focus of AD research has been on ... -
Vitamin K and Calcium Chelation in Vascular Health
Aaseth, Jan; Alehagen, Urban; Opstad, Trine Baur; Alexander, Jan (Peer reviewed; Journal article, 2023)The observation that the extent of artery calcification correlates with the degree of atherosclerosis was the background for the alternative treatment of cardiovascular disease with chelator ethylenediamine tetraacetate ...