• Body Temperature during Hibernation Is Highly Correlated with a Decrease in Circulating Innate Immune Cells in the Brown Bear (Ursus arctos): A Common Feature among Hibernators? 

      Sahdo, Berolla; Evans, Alina L.; Arnemo, Jon Martin; Fröbert, Ole; Särndahl, Eva; Blanc, Stéphane (Journal article; Peer reviewed, 2013)
      Background: Hibernation involves periods of severely depressed metabolism (torpor) and decreases in body temperature (Tb). Small arctic mammals (<5kg), in which Tb generally drop drastically, display leukopenia during ...
    • Concurrent BMP signalling maintenance and TGF-β signalling inhibition is a hallmark of natural resistance to muscle atrophy in the hibernating bear 

      Cussonneau, Laura; Boyer, Christian; Brun, Charlotte; Deval, Christiane; Loizon, Emmanuelle; Meugnier, Emmanuelle; Gueret, Elise; Dubois, Emeric; Taillandier, Daniel; Polge, Cecile; Bechet, Daniel; Gauquelin-Koch, Guillemette; Evans, Alina; Arnemo, Jon Martin; Swenson, Jon; Blanc, Stéphane; Simon, Chantal; Lefai, Etienne; Bertile, Fabrice; Combaret, Lydie (Peer reviewed; Journal article, 2021)
      Abstract: Muscle atrophy arises from a multiplicity of physio-pathological situations and has very detrimental consequences for the whole body. Although knowledge of muscle atrophy mechanisms keeps growing, there is still ...
    • Hibernating brown bears are protected against atherogenic dyslipidemia 

      Giroud, Sylvain; Chery, Isabelle; Arrivé, Mathilde; Prost, Michel; Zumsteg, Julie; Heintz, Dimitri; Evans, Alina; Gauquelin-Koch, Guillemette; Arnemo, Jon Martin; Swenson, Jon E.; Lefai, Etienne; Bertile, Fabrice; Simon, Chantal; Blanc, Stéphane (Peer reviewed; Journal article, 2021)
      To investigate mechanisms by which hibernators avoid atherogenic hyperlipidemia during hibernation, we assessed lipoprotein and cholesterol metabolisms of free-ranging Scandinavian brown bears (Ursus arctos). In winter- ...
    • Limited oxidative stress favors resistance to skeletal muscle atrophy in hibernating brown bears (Ursus Arctos) 

      Chazarin, Blandine; Ziemianin, Anna; Evans, Alina L.; Meugnier, Emmanuelle; Loizon, Emmanuelle; Chery, Isabelle; Arnemo, Jon Martin; Swenson, Jon; Gauquelin-Koch, Guillemette; Simon, Chantal; Blanc, Stéphane; Lefai, Etienne; Bertile, Fabrice (Peer reviewed; Journal article, 2019)
    • Lipidomics reveals seasonal shifts in a large-bodied hibernator, the brown bear 

      Giroud, Sylvain; Chery, Isabelle; Bertile, Fabrice; Bertrand-Michel, Justine; Tascher, Georg; Gauquelin-Koch, Guillemette; Arnemo, Jon Martin; Swenson, Jon; Singh, Navinder; Lefai, Etienne; Evans, Alina L.; Simon, Chantal; Blanc, Stéphane (Peer reviewed; Journal article, 2019)
    • Physiological reactions to capture in hibernating brown bears 

      Evans, Alina L.; Singh, Navinder J.; Fuchs, Boris; Blanc, Stéphane; Friebe, Andrea; Laske, Timothy; Fröbert, Ole; Swenson, Jon; Arnemo, Jon Martin (Peer reviewed; Journal article, 2016)
    • Proteolysis inhibition by hibernating bear serum leads to increased protein content in human muscle cells 

      Chanon, Stéphanie; Chazarin, Blandine; Toubhans, Benoit; Durand, Christine; Chery, Isabelle; Robert, Maud; Vieille-Marchiset, Aurélie; Swenson, Jon; Zedrosser, Andreas; Evans, Alina L.; Brunberg, Sven; Arnemo, Jon Martin; Gauquelin-Koch, Guillemette; Storey, Kenneth B.; Simon, Chantal; Blanc, Stéphane; Bertile, Fabrice; Lefai, Etienne (Journal article; Peer reviewed, 2018)
      Muscle atrophy is one of the main characteristics of human ageing and physical inactivity, with resulting adverse health outcomes. To date, there are still no efcient therapeutic strategies for its prevention and/or ...
    • Seasonal changes in eicosanoid metabolism in the brown bear 

      Giroud, Sylvain; Evans, Alina L.; Chery, Isabelle; Bertile, Fabrice; Tascher, Georg; Bertrand-Michel, Justine; Gauquelin-Koch, Guillemette; Arnemo, Jon Martin; Swenson, Jon; Lefai, Etienne; Blanc, Stéphane; Simon, Chantal (Peer reviewed; Journal article, 2018)
    • Seasonal variation in haematological and biochemical variables in free-ranging subadult brown bears (Ursus arctos) in Sweden 

      Græsli, Anne Randi; Evans, Alina L.; Fahlman, Åsa; Bertelsen, Mads Frost; Blanc, Stéphane; Arnemo, Jon Martin (Journal article, 2015)
      Background: Free-ranging brown bears exhibit highly contrasting physiological states throughout the year. They hibernate 6 months of the year, experiencing a decrease in body temperature, heart rate, respiratory rate and ...
    • Specific shifts in the endocannabinoid system in hibernating brown bears 

      Boyer, Christian; Cussonneau, Laura; Brun, Charlotte; Deval, Christiane; Pais de Barros, Jean-Paul; Chanon, Stéphanie; Bernoud-Hubac, Nathalie; Daira, Patricia; Evans, Alina L.; Arnemo, Jon Martin; Swenson, Jon; Gauquelin-Koch, Guillemette; Simon, Chantal; Blanc, Stéphane; Combaret, Lydie; Bertile, Fabrice; Lefai, Etienne (Peer reviewed; Journal article, 2020)
      In small hibernators, global downregulation of the endocannabinoid system (ECS), which is involved in modulating neuronal signaling, feeding behavior, energy metabolism, and circannual rhythms, has been reported to possibly ...