Browsing Brage INN by Author "Larsson, Anders"
Now showing items 1-7 of 7
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Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: a subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK
Alehagen, Urban; Alexander, Jan; Aaseth, Jan; Larsson, Anders (Journal article; Peer reviewed, 2019)Background Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons ... -
Effects of an Intervention with Selenium and Coenzyme Q<inf>10</inf> on Five Selected Age-Related Biomarkers in Elderly Swedes Low in Selenium: Results That Point to an Anti-Ageing Effect—A Sub-Analysis of a Previous Prospective Double-Blind Placebo-Controlled Randomised Clinical Trial
Alehagen, Urban; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Svensson, Erland; Opstad, Trine Baur (Peer reviewed; Journal article, 2023)Background: Ageing is associated with cardiovascular disease (CVD). As no single biomarker reflects the full ageing process, we aimed to investigate five CVD- and age-related markers and the effects of selenium and coenzyme ... -
Impact of selenium on biomarkers and clinical aspects related to ageing. A review
Alehagen, Urban; Opstad, Trine B.; Alexander, Jan; Larsson, Anders; Aaseth, Jan (Peer reviewed; Journal article, 2021)Selenium (Se) is an essential dietary trace element that plays an important role in the prevention of inflammation, cardiovascular diseases, infections, and cancer. Selenoproteins contain selenocysteine in the active center ... -
Increased SIRT1 Concentration Following Four Years of Selenium and Q<inf>10</inf> Intervention Associated with Reduced Cardiovascular Mortality at 10-Year Follow-Up—Sub-Study of a Previous Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial
Opstad, Trine Baur; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Seljeflot, Ingebjørg; Alehagen, Urban (Peer reviewed; Journal article, 2023)Background: Selenium and coenzyme Q10 (SeQ10) possess antioxidant and anti-inflammatory properties, potentially mediated via Sirtuin1 (SIRT1). We aimed to investigate the influence of a SeQ10 intervention on SIRT1 ... -
Selenium and coenzyme Q<inf>10</inf> improve the systemic redox status while reducing cardiovascular mortality in elderly population-based individuals
Dunning, Belinda J.; Bourgonje, Arno R.; Bulthuis, Marian L.C.; Alexander, Jan; Aaseth, Jan; Larsson, Anders; van Goor, Harry; Alehagen, Urban (Peer reviewed; Journal article, 2023)Background Serum sulfhydryl groups (R–SH, free thiols) reflect the systemic redox status in health and disease, and may be amenable to therapeutic modulation. Since R–SH are readily oxidized by reactive species, oxidative ... -
Selenium and Coenzyme Q<inf>10</inf> Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality-Sub-Study of a Randomized Clinical Trial
Opstad, Trine Baur; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Seljeflot, Ingebjørg; Alehagen, Urban (Peer reviewed; Journal article, 2022)Short telomeres have been associated with ageing and cardiovascular disease. The influence on leukocyte telomere length (LTL) of long-term intervention with combined selenium and coenzyme Q10 is unknown. Our aim was to ... -
Supplementation with selenium and coenzyme Q<inf>10</inf> in an elderly Swedish population low in selenium — positive effects on thyroid hormones, cardiovascular mortality, and quality of life
Alehagen, Urban; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Opstad, Trine Baur (Peer reviewed; Journal article, 2024)Background Selenium-dependent deiodinases play a central role in thyroid hormone regulation and metabolism. In many European countries, insufficient selenium intake may consequently lead to adverse effects on thyroid ...