Blar i Brage INN på forfatter "Aaseth, Jan"
-
APOE Polymorphism and Endocrine Functions in Subjects with Morbid Obesity Undergoing Bariatric Surgery
Farup, Per Grønaas; Jansen, Aina; Hestad, Knut; Aaseth, Jan; Rootwelt, Helge (Peer reviewed; Journal article, 2022)Background: Obesity is an interplay between genes and the environment, including lifestyle. The genetics of obesity is insufficiently understood. Apolipoprotein E (APOE) genetic polymorphism has been associated with a wide ... -
Cadmium, lead and mercury in Norwegian obese patients before and 12 months after bariatric surgery
Mikalsen, Solveig Meyer; Monsen, Anne Lise Bjørke; Flaten, Trond Peder; Whist, Jon Elling; Aaseth, Jan (Peer reviewed; Journal article, 2019)Purpose Previous studies have suggested a role for the toxic elements lead (Pb), mercury (Hg) and cadmium (Cd) in the development of insulin resistance and hypertension. Increased blood Pb levels have been reported after ... -
Changes in circulating sirtuin 1 after bariatric surgery
Opstad, Trine Baur; Farup, Per Grønaas; Rootwelt, Helge; Aaseth, Jan (Peer reviewed; Journal article, 2022)Background and aims: Obesity is associated with chronic inflammation and oxidative stress. Weight loss after bariatric surgery improves the inflammatory state and risk of cardiovascular disease. Improvement in metabolic ... -
Chelation Combination - A Strategy to Mitigate the Neurotoxicity of Manganese, Iron, and Copper?
Aaseth, Jan; Nurchi, Valeria M. (Peer reviewed; Journal article, 2022)The chelating thiol dimercaptosuccinate (DMSA) and the traditional agent D-penicillamine (PSH) are effective in enhancing the urinary excretion of copper (Cu) and lead (Pb) in poisoned individuals. However, DMSA, PSH, EDTA ... -
Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach
Bjørklund, Geir; Dadar, Maryam; Pen, Joeri J.; Chirumbolo, Salvatore; Aaseth, Jan (Peer reviewed; Journal article, 2019)Chronic fatigue syndrome (CFS) is known as a multi-systemic and complex illness, which induces fatigue andlong-term disability in educational, occupational, social, or personal activities. The diagnosis of this disease ... -
Circulating Lipoproteins in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy
Aaseth, Jan; Rootwelt, Helge; Retterstøl, Kjetil; Hestad, Knut; Farup, Per Grønaas (Peer reviewed; Journal article, 2022)The efficacy of various bariatric procedures on the mitigation of the obese dyslipidemia remains debated, and the impact of these measures on lipoprotein(a) (Lp(a)) levels is unknown. In this study we aimed to compare the ... -
Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: a subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK
Alehagen, Urban; Alexander, Jan; Aaseth, Jan; Larsson, Anders (Journal article; Peer reviewed, 2019)Background Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons ... -
Diets and drugs for weight loss and health in obesity – An update
Aaseth, Jan; Ellefsen, Stian; Alehagen, Urban; Sundfør, Tine M.; Alexander, Jan (Peer reviewed; Journal article, 2021)Numerous combinations of diets and pharmacological agents, including lifestyle changes, have been launched to treat obesity. There are still ambiguities regarding the efficacies of different approaches despite many clinical ... -
Dose-response relationship between dietary magnesium intake and cardiovascular mortality: A systematic review and dose-based meta-regression analysis of prospective studies
Fang, Xin; Liang, Chun; Li, Mei; Montgomery, Scott; Fall, Katja; Aaseth, Jan; Cao, Yang (Journal article; Peer reviewed, 2016)Background Although epidemiology studies have reported the relationship, including a dose-response relationship, between dietary magnesium intake and risk of cardiovascular disease (CVD), the risk for CVD mortality is ... -
Dose-response relationship between dietary magnesium intake, serum magnesium concentration and risk of hypertension: a systematic review and meta-analysis of prospective cohort studies
Han, Hedong; Fang, Xin; Wei, Xin; Liu, Yuzhou; Jin, Zhicao; Chen, Qi; Fan, Zhongjie; Aaseth, Jan; Hiyoshi, Ayako; He, Jia; Cao, Yang (Peer reviewed; Journal article, 2017)Background The findings of prospective cohort studies are inconsistent regarding the association between dietary magnesium intake and serum magnesium concentration and the risk of hypertension. We aimed to review the ... -
Effects of an Intervention with Selenium and Coenzyme Q<inf>10</inf> on Five Selected Age-Related Biomarkers in Elderly Swedes Low in Selenium: Results That Point to an Anti-Ageing Effect—A Sub-Analysis of a Previous Prospective Double-Blind Placebo-Controlled Randomised Clinical Trial
Alehagen, Urban; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Svensson, Erland; Opstad, Trine Baur (Peer reviewed; Journal article, 2023)Background: Ageing is associated with cardiovascular disease (CVD). As no single biomarker reflects the full ageing process, we aimed to investigate five CVD- and age-related markers and the effects of selenium and coenzyme ... -
Gadolinium in Medical Imaging - Usefulness, Toxic Reactions and Possible Countermeasures - A Review
Blomqvist, Lennart; Nordberg, Gunnar F.; Nurchi, Valeria M.; Aaseth, Jan (Peer reviewed; Journal article, 2022)Gadolinium (Gd) is one of the rare-earth elements. The properties of its trivalent cation (Gd3+) make it suitable to serve as the central ion in chelates administered intravenously to patients as a contrast agent in magnetic ... -
Impact of selenium on biomarkers and clinical aspects related to ageing. A review
Alehagen, Urban; Opstad, Trine B.; Alexander, Jan; Larsson, Anders; Aaseth, Jan (Peer reviewed; Journal article, 2021)Selenium (Se) is an essential dietary trace element that plays an important role in the prevention of inflammation, cardiovascular diseases, infections, and cancer. Selenoproteins contain selenocysteine in the active center ... -
The Importance of Vitamin K and the Combination of Vitamins K and D for Calcium Metabolism and Bone Health: A Review
Aaseth, Jan; Finnes, Trine Elisabeth; Askim, Merete; Alexander, Jan (Peer reviewed; Journal article, 2024)The aim of the present review is to discuss the roles of vitamin K (phylloquinone or menaquinones) and vitamin K-dependent proteins, and the combined action of the vitamins K and D, for the maintenance of bone health. The ... -
Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden
Alehagen, Urban; Johansson, Peter; Svensson, Erland; Aaseth, Jan; Alexander, Jan (Peer reviewed; Journal article, 2022)Purpose Selenium and coenzyme Q10 have synergistic antioxidant functions. In a four-year supplemental trial in elderly Swedes with a low selenium status, we found improved cardiac function, less cardiac wall tension and ... -
Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10. A prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Brismar, Kerstin (Peer reviewed; Journal article, 2017) -
Increased SIRT1 Concentration Following Four Years of Selenium and Q<inf>10</inf> Intervention Associated with Reduced Cardiovascular Mortality at 10-Year Follow-Up—Sub-Study of a Previous Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial
Opstad, Trine Baur; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Seljeflot, Ingebjørg; Alehagen, Urban (Peer reviewed; Journal article, 2023)Background: Selenium and coenzyme Q10 (SeQ10) possess antioxidant and anti-inflammatory properties, potentially mediated via Sirtuin1 (SIRT1). We aimed to investigate the influence of a SeQ10 intervention on SIRT1 ... -
Inpatients experiences about the impact of traumatic stress on eating behaviors: an exploratory focus group study
Roer, Grethe Emilie; Hurlen Solbakken, Heidi; Abebe, Dawit Shawel; Aaseth, Jan; Bolstad, Ingeborg; Lien, Lars (Peer reviewed; Journal article, 2021)This study aimed to explore trauma-exposed inpatients experiences about the impact of traumatic stress on eating behavior. Thirteen female and two male inpatients with a history of trauma, recruited from a psychiatric ... -
Iron chelation in the treatment of neurodegenerative diseases
Dusek, Petr; Schneider, Susanne A.; Aaseth, Jan (Journal article; Peer reviewed, 2016)Disturbance of cerebral iron regulation is almost universal in neurodegenerative disorders. There is a growing body of evidence that increased iron deposits may contribute to degenerative changes. Thus, the effect of iron ... -
Is there a relationship between PTSD and complicated obesity? A review of the literature
Aaseth, Jan; Roer, Grethe Emilie; Lien, Lars; Bjørklund, Geir (Peer reviewed; Journal article, 2019)Recent research strongly supports the hypothesis that posttraumatic stress disorder (PTSD) can be accompanied by obesity and related metabolic disturbances. The mechanisms of these associations are however still not well ...