Blar i Brage INN på forfatter "Aaseth, Jan"
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Cadmium, lead and mercury in Norwegian obese patients before and 12 months after bariatric surgery
Mikalsen, Solveig Meyer; Monsen, Anne Lise Bjørke; Flaten, Trond Peder; Whist, Jon Elling; Aaseth, Jan (Peer reviewed; Journal article, 2019)Purpose Previous studies have suggested a role for the toxic elements lead (Pb), mercury (Hg) and cadmium (Cd) in the development of insulin resistance and hypertension. Increased blood Pb levels have been reported after ... -
Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach
Bjørklund, Geir; Dadar, Maryam; Pen, Joeri J.; Chirumbolo, Salvatore; Aaseth, Jan (Peer reviewed; Journal article, 2019)Chronic fatigue syndrome (CFS) is known as a multi-systemic and complex illness, which induces fatigue andlong-term disability in educational, occupational, social, or personal activities. The diagnosis of this disease ... -
Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: a subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK
Alehagen, Urban; Alexander, Jan; Aaseth, Jan; Larsson, Anders (Journal article; Peer reviewed, 2019)Background Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons ... -
Dose-response relationship between dietary magnesium intake and cardiovascular mortality: A systematic review and dose-based meta-regression analysis of prospective studies
Fang, Xin; Liang, Chun; Li, Mei; Montgomery, Scott; Fall, Katja; Aaseth, Jan; Cao, Yang (Journal article; Peer reviewed, 2016)Background Although epidemiology studies have reported the relationship, including a dose-response relationship, between dietary magnesium intake and risk of cardiovascular disease (CVD), the risk for CVD mortality is ... -
Dose-response relationship between dietary magnesium intake, serum magnesium concentration and risk of hypertension: a systematic review and meta-analysis of prospective cohort studies
Han, Hedong; Fang, Xin; Wei, Xin; Liu, Yuzhou; Jin, Zhicao; Chen, Qi; Fan, Zhongjie; Aaseth, Jan; Hiyoshi, Ayako; He, Jia; Cao, Yang (Peer reviewed; Journal article, 2017)Background The findings of prospective cohort studies are inconsistent regarding the association between dietary magnesium intake and serum magnesium concentration and the risk of hypertension. We aimed to review the ... -
Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10. A prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Brismar, Kerstin (Peer reviewed; Journal article, 2017) -
Iron chelation in the treatment of neurodegenerative diseases
Dusek, Petr; Schneider, Susanne A.; Aaseth, Jan (Journal article; Peer reviewed, 2016)Disturbance of cerebral iron regulation is almost universal in neurodegenerative disorders. There is a growing body of evidence that increased iron deposits may contribute to degenerative changes. Thus, the effect of iron ... -
Is there a relationship between PTSD and complicated obesity? A review of the literature
Aaseth, Jan; Roer, Grethe Emilie; Lien, Lars; Bjørklund, Geir (Peer reviewed; Journal article, 2019)Recent research strongly supports the hypothesis that posttraumatic stress disorder (PTSD) can be accompanied by obesity and related metabolic disturbances. The mechanisms of these associations are however still not well ... -
Lead poisoning among opium users in Iran: an emerging health hazard
Hayatbakhsh, Mohammad Mahdi; Oghabian, Zohreh; Conlon, Elvira; Nakhaee, Samaneh; Amirabadizadeh, Ali Reza; Zahedi, Mohammad Javad; Moghadam, Sodief Darvish; Ahmadi, Bighan; Soroush, Somayeh; Aaseth, Jan; Mehrpour, Omid (Peer reviewed; Journal article, 2017)Background Lead (Pb) poisoning among people using opium has been an increasing problem in Iran. The present study highlights the clinical effects of lead toxicity associated with opium use in Iran, Kerman province. Methods ... -
Levels of sP-selectin and hs-CRP Decrease with Dietary Intervention with Selenium and Coenzyme Q10 Combined: A Secondary Analysis of a Randomized Clinical Trial
Alehagen, Urban; Lindahl, Tomas L.; Aaseth, Jan; Svensson, Erland; Johansson, Peter (Journal article; Peer reviewed, 2015-09-16)Background/Objectives Inflammation and oxidative stress are central in many disease states. The major anti-oxidative enzymes contain selenium. The selenium intake in Europe is low, and supplementation with selenium and ... -
Mercury exposure and its effects on fertility and pregnancy outcome
Bjørklund, Geir; Chirumbolo, Salvatore; Dadar, Maryam; Pivina, Lyudmila; Lindh, Ulf; Butnariu, Monica; Aaseth, Jan (Peer reviewed; Journal article, 2019)Mercury (Hg), a highly toxic environmental pollutant, shows harmfulness which still represents a big concern for human health, including hazards to fertility and pregnancy outcome. Research has shown that Hg could induce ... -
Prevention of progression in Parkinson’s disease
Aaseth, Jan; Dusek, Petr; Roos, Per M. (Peer reviewed; Journal article, 2018)Environmental influences affecting genetically susceptible individuals seem to contribute significantly to the development of Parkinson’s disease (PD). Xenobiotic exposure including transitional metal deposition into ... -
Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized DoubleBlind Placebo-Controlled Trial in Elderly Citizens
Alehagen, Urban; Aaseth, Jan; Johansson, Peter (Journal article; Peer reviewed, 2015)BACKGROUND: Selenium and coenzyme Q10 are important antioxidants in the body. As the intake of selenium is low in Europe, and the endogenous production of coenzyme Q10 decreases as age increases, an intervention trial using ... -
A review on coordination properties of thiol-containing chelating agents towards mercury, cadmium, and lead
Bjørklund, Geir; Crisponi, Guido; Nurchi, Valeria Marina; Cappai, Rosita; Djordjevic, Aleksandra Buha; Aaseth, Jan (Peer reviewed; Journal article, 2019)Abstract: The present article reviews the clinical use of thiol-based metal chelators in intoxications and overexposure with mercury (Hg), cadmium (Cd), and lead (Pb). Currently, very few commercially available pharmaceuticals ... -
Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Wågsäter, Dick (Journal article; Peer reviewed, 2017)Background Selenium and coenzyme Q10 is essential for important cellular functions. A low selenium intake is reported from many European countries, and the endogenous coenzyme Q10 production is decreasing in the body with ... -
Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly
Alehagen, Urban; Aaseth, Jan; Alexander, Jan; Johansson, Peter (Peer reviewed; Journal article, 2018)Selenium and coenzyme Q10 are both necessary for optimal cell function in the body. The intake of selenium is low in Europe, and the endogenous production of coenzyme Q10 decreases as age increases. Therefore, an intervention ... -
Supplementation with Selenium and Coenzyme Q10 Reduces Cardiovascular Mortality in Elderly with Low Selenium Status: A Secondary Analysis of a Randomised Clinical Trial
Alehagen, Urban; Alexander, Jan; Aaseth, Jan (Journal article; Peer reviewed, 2016)Background Selenium is needed by all living cells in order to ensure the optimal function of several enzyme systems. However, the selenium content in the soil in Europe is generally low. Previous reports indicate that a ... -
Treatment strategies in Alzheimer’s disease: a review with focus on selenium supplementation
Aaseth, Jan; Alexander, Jan; Bjørklund, Geir; Hestad, Knut; Dusek, Petr; Roos, Per M.; Alehagen, Urban (Journal article; Peer reviewed, 2016)Alzheimer’s disease (AD) is a neurodegenerative disorder presenting one of the biggest healthcare challenges in developed countries. No effective treatment exists. In recent years the main focus of AD research has been on ...