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Platelet function in brown bear (Ursus arctos) compared to man

Fröbert, Ole; Christensen, Kjeld; Fahlman, Åsa; Brunberg, Sven; Josefsson, Johan; Särndahl, Eva; Swenson, Jon E.; Arnemo, Jon Martin
Journal article, Peer reviewed
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1477-9560-8-11.pdf (502.5Kb)
Permanent link
http://hdl.handle.net/11250/134324
Issue date
2010
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  • Artikkel - fagfellevurdert vitenskapelig / Articles - peer-reviewed [917]
Original version
Fröbert et al. (2010). Platelet function in brown bear (Ursus arctos) compared to man. Trombosis Journal 8(11)  
Abstract
Background: Information on hemostasis and platelet function in brown bear (Ursus arctos) is of importance for

understanding the physiological, protective changes during hibernation.

Objective: The study objective was to document platelet activity values in brown bears shortly after leaving the den

and compare them to platelet function in healthy humans.

Methods: Blood was drawn from immobilized wild brown bears 7-10 days after leaving the den in mid April. Blood

samples from healthy human adults before and after clopidogrel and acetylsalicylic acid administration served as

control. We analyzed blood samples by standard blood testing and platelet aggregation was quantified after

stimulation with various agonists using multiple electrode aggregometry within 3 hours of sampling.

Results: Blood samples were collected from 6 bears (3 females) between 1 and 16 years old and from 10 healthy

humans. Results of adenosine diphosphate, aspirin, and thrombin receptor activating peptide tests in bears were all

half or less of those in humans. Platelet and white blood cell counts did not differ between species but brown bears

had more and smaller red blood cells compared with humans.

Conclusion: Using three different tests, we conclude that platelet function is lower in brown bears compared to

humans. Our findings represent the first descriptive study on platelet function in brown bears and may contribute to

explain how bears can endure denning without obvious thrombus building. However, the possibility that our findings

reflect test-dependent and not true biological variations in platelet reactivity needs further studies.
Description
The article can also be located here: http://www.thrombosisjournal.com/content/8/1/11
Publisher
Thrombosis Journal

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