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Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation

Fink, Trine; Rasmussen, Jeppe G.; Emmersen, Jeppe; Fahlman, Åsa; Brunberg, Sven; Josefsson, Johan; Arnemo, Jon Martin; Zachar, Vladimir; Swenson, Jon E.; Fröbert, Ole
Journal article, Peer reviewed
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URI
http://hdl.handle.net/11250/134346
Date
2011
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  • Artikkel - fagfellevurdert vitenskapelig / Articles - peer-reviewed [1252]
Original version
Fink, T. Rasmussen, J.G., Emmersen, J., Fahlman, Å., Brunberg, S., Josefsson, J., Arnemo, J.M., Zachar, V., Swenson, J.E. & Fröbert, O. (2011). Adipose-derived stem cells from the brown bear (Ursus arctos) spontaneously undergo chondrogenic and osteogenic differentiation. Stem Cell Research 7(1), 89-95   http://dx.doi.org/10.1016/j.scr.2011.03.003
Abstract
In the den, hibernating brown bears do not develop tissue atrophy or organ damage, despite

almost no physical activity. Mesenchymal stem cells could play an important role in tissue repair and

regeneration in brown bears. Our objective was to determine if adipose tissue-derived stem cells

(ASCs) can be recovered from adipose tissue of wild Scandinavian brown bears and characterize

osteogenic, chondrogenic, and adipogenic differentiation in the cells. Following immobilization of 8

wild brown bears 7-10 days after leaving the den in mid-April, adipose tissue biopsies (5-8 ml) were

obtained subcutaneously from 7 bears. ASCs were recovered and characterized. Adipose stem cell

cultures were established from 6 of 7 bears. Adipose tissue-derived stem cells from yearlings

spontaneously formed bone-like nodules surrounded by cartilaginous deposits, suggesting

differentiation into osteogenic and chondrogenic lineages. This ability appears to be lost gradually with

age. This is the first study to demonstrate stem cell recovery and growth from brown bears, and it is

the first report of ASCs spontaneously differentiating into osteocytes and chondrocytes. These findings

could have implications for the use of hibernating brown bears as a model to study osteoporosis.
Description
Dette er post-print versjonen av artikkelen. Den trykte versjonen kan leses her: http://www.sciencedirect.com/science/article/pii/S1873506111000286
Publisher
Elsevier
Journal
Stem Cell Research

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