Blar i Publikasjoner fra Cristin - INN på forfatter "Aaseth, Jan"
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Prevention of progression in Parkinson’s disease
Aaseth, Jan; Dusek, Petr; Roos, Per M. (Peer reviewed; Journal article, 2018)Environmental influences affecting genetically susceptible individuals seem to contribute significantly to the development of Parkinson’s disease (PD). Xenobiotic exposure including transitional metal deposition into ... -
A review on coordination properties of thiol-containing chelating agents towards mercury, cadmium, and lead
Bjørklund, Geir; Crisponi, Guido; Nurchi, Valeria Marina; Cappai, Rosita; Djordjevic, Aleksandra Buha; Aaseth, Jan (Peer reviewed; Journal article, 2019)Abstract: The present article reviews the clinical use of thiol-based metal chelators in intoxications and overexposure with mercury (Hg), cadmium (Cd), and lead (Pb). Currently, very few commercially available pharmaceuticals ... -
The Role of Persistent Organic Pollutants in Obesity: A Review of Laboratory and Epidemiological Studies
Aaseth, Jan; Javorac, Dragana; Djordjevic, Aleksandra Buha; Bulat, Zorica; Skalny, Anatoly V.; Zaitseva, Irina P.; Aschner, Michael; Tinkov, Alexey A. (Peer reviewed; Journal article, 2022)Persistent organic pollutants (POPs) are considered as potential obesogens that may affect adipose tissue development and functioning, thus promoting obesity. However, various POPs may have different mechanisms of action. ... -
The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases
Hestad, Knut; Alexander, Jan; Rootwelt, Helge; Aaseth, Jan (Peer reviewed; Journal article, 2022-07-18)Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several ... -
Selenium and coenzyme Q<inf>10</inf> improve the systemic redox status while reducing cardiovascular mortality in elderly population-based individuals
Dunning, Belinda J.; Bourgonje, Arno R.; Bulthuis, Marian L.C.; Alexander, Jan; Aaseth, Jan; Larsson, Anders; van Goor, Harry; Alehagen, Urban (Peer reviewed; Journal article, 2023)Background Serum sulfhydryl groups (R–SH, free thiols) reflect the systemic redox status in health and disease, and may be amenable to therapeutic modulation. Since R–SH are readily oxidized by reactive species, oxidative ... -
Selenium and Coenzyme Q<inf>10</inf> Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality-Sub-Study of a Randomized Clinical Trial
Opstad, Trine Baur; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Seljeflot, Ingebjørg; Alehagen, Urban (Peer reviewed; Journal article, 2022)Short telomeres have been associated with ageing and cardiovascular disease. The influence on leukocyte telomere length (LTL) of long-term intervention with combined selenium and coenzyme Q10 is unknown. Our aim was to ... -
Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Wågsäter, Dick (Journal article; Peer reviewed, 2017)Background Selenium and coenzyme Q10 is essential for important cellular functions. A low selenium intake is reported from many European countries, and the endogenous coenzyme Q10 production is decreasing in the body with ... -
Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly
Alehagen, Urban; Aaseth, Jan; Alexander, Jan; Johansson, Peter (Peer reviewed; Journal article, 2018)Selenium and coenzyme Q10 are both necessary for optimal cell function in the body. The intake of selenium is low in Europe, and the endogenous production of coenzyme Q10 decreases as age increases. Therefore, an intervention ... -
Vitamin K and Calcium Chelation in Vascular Health
Aaseth, Jan; Alehagen, Urban; Opstad, Trine Baur; Alexander, Jan (Peer reviewed; Journal article, 2023)The observation that the extent of artery calcification correlates with the degree of atherosclerosis was the background for the alternative treatment of cardiovascular disease with chelator ethylenediamine tetraacetate ...