Blar i Publikasjoner fra Cristin - INN på tidsskrift "Biomolecules"

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    • Cerebral Iron Deposition in Neurodegeneration 

      Dusek, Petr; Hofer, Tim; Alexander, Jan; Roos, Per M.; Aaseth, Jan Olav (Peer reviewed; Journal article, 2022)
      Disruption of cerebral iron regulation appears to have a role in aging and in the pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron accumulation include reactive oxygen species ...

    • Chelation Combination - A Strategy to Mitigate the Neurotoxicity of Manganese, Iron, and Copper? 

      Aaseth, Jan; Nurchi, Valeria M. (Peer reviewed; Journal article, 2022)
      The chelating thiol dimercaptosuccinate (DMSA) and the traditional agent D-penicillamine (PSH) are effective in enhancing the urinary excretion of copper (Cu) and lead (Pb) in poisoned individuals. However, DMSA, PSH, EDTA ...

    • Gadolinium in Medical Imaging - Usefulness, Toxic Reactions and Possible Countermeasures - A Review 

      Blomqvist, Lennart; Nordberg, Gunnar F.; Nurchi, Valeria M.; Aaseth, Jan (Peer reviewed; Journal article, 2022)
      Gadolinium (Gd) is one of the rare-earth elements. The properties of its trivalent cation (Gd3+) make it suitable to serve as the central ion in chelates administered intravenously to patients as a contrast agent in magnetic ...

    • Impact of selenium on biomarkers and clinical aspects related to ageing. A review 

      Alehagen, Urban; Opstad, Trine B.; Alexander, Jan; Larsson, Anders; Aaseth, Jan (Peer reviewed; Journal article, 2021)
      Selenium (Se) is an essential dietary trace element that plays an important role in the prevention of inflammation, cardiovascular diseases, infections, and cancer. Selenoproteins contain selenocysteine in the active center ...

    • The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases 

      Hestad, Knut; Alexander, Jan; Rootwelt, Helge; Aaseth, Jan (Peer reviewed; Journal article, 2022-07-18)
      Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several ...

    • An Update on S100A16 in Human Cancer 

      Basnet, Suyog; Vallenari, Evan Michael; Maharjan, Urusha; Sharma, Sunita; Schreurs, Olaf Joseph Franciscus; Sapkota, Dipak (Peer reviewed; Journal article, 2023)
      S100A16 is a member of the S100 protein family. S100A16 is expressed in a variety of human tissues, although at varying levels. S100A16 expression is especially high in tissues rich in epithelial cells. mRNA and protein ...