Vis enkel innførsel

dc.contributor.authorJørgensen, Peter Godsk
dc.contributor.authorArnemo, Jon Martin
dc.contributor.authorSwenson, Jon E.
dc.contributor.authorJensen, Jan S.
dc.contributor.authorGalatius, Søren
dc.contributor.authorFrøbert, Ole
dc.date.accessioned2015-02-19T08:53:20Z
dc.date.available2015-02-19T08:53:20Z
dc.date.issued2014
dc.identifier.citationJørgensen et al. (2014). Low cardiac output as physiological phenomenon in hibernating, free-ranging Scandinavian brown bears ( Ursus arctos ) : an observational study. Cardiovascular Ultrasound 2014, 12 :36 http://www.cardiovascularultrasound.com/content/12/1/36nb_NO
dc.identifier.urihttp://hdl.handle.net/11250/276712
dc.description.abstractBackground: Despite 5-7 months of physical inactivity during hibernation, brown bears (Ursus arctos) are able to cope with physiological conditions that would be detrimental to humans. During hibernation, the tissue metabolic demands fall to 25% of the active state. Our objective was to assess cardiac function associated with metabolic depression in the hibernating vs. active states in free-ranging Scandinavian brown bears. Methods: We performed echocardiography on seven free-ranging brown bears in Dalarna, Sweden, anesthetized with medetomidine-zolazepam-tiletamine-ketamin e during winter hibernation in February 2013 and with medetomidine-zolazepam-tiletamine during active state in June 2013. We measured cardiac output noninvasively using estimates of hemodynamics obtained by pulsed wave Doppler echocardiography and 2D imaging. Comparisons were made using paired T-tests. Results: During hibernation, all hemodynamic indices were significantly decreased (hibernating vs. active state): mean heart rate was 26.0 (standard deviation (SD): 5.6) beats per min vs. 75.0 (SD: 17.1) per min (P = 0.002), mean stroke volume 32.3 (SD: 5.2) ml vs. 47.1 (SD: 7.9) ml (P = 0.008), mean cardiac output 0.86 (SD: 0.31) l/min vs. 3.54 (SD: 1.04) l/min (P = 0.003), and mean cardiac index 0.63 (SD: 0.21) l/min/kg vs. 2.45 (SD: 0.52) l/min/ m 2 (P < 0.001). Spontaneous echo contrast was present in all cardiac chambers in all seven bears during hibernation, despite the absence of atrial arrhythmias and valvular disease. Conclusion: Free-ranging brown bears demonstrate hemodynamics comparable to humans during active state, whereas during hibernation, we documented extremely low-flow hemodynamics. Understanding these physiological changes in bears may help to gain insight into the mechanisms of cardiogenic shock and heart failure in humansnb_NO
dc.language.isoengnb_NO
dc.publisherCardiovascular Ultrasoundnb_NO
dc.subjectAnimal model cardiovascular disease,nb_NO
dc.subjectAcute cardiac carenb_NO
dc.subjectThrombosisnb_NO
dc.subjectEchocardiographynb_NO
dc.titleLow cardiac output as physiological phenomenon in hibernating, free-ranging Scandinavian brown bears ( Ursus arctos ) : an observational studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.volume12nb_NO
dc.source.journalCardiovascular Ultrasoundnb_NO
dc.source.issue36nb_NO
dc.identifier.doi10.1186/1476-7120-12-36


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel