Browsing Brage INN by Author "Engedal, Knut"
Now showing items 1-11 of 11
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Apolipoprotein E (APOE) allelet er av vesentlig betydning for hukommelse og demensutvikling hos de eldste
Hestad, Knut; Strand, Bjørn Heine; Engedal, Knut (Peer reviewed; Journal article, 2023)De mest typiske patologiske forandringene i hjernen ved Alzheimers sykdom er avleiring av beta-amyloid i nevritiske plakk ekstracellulært, samt dannelse av nevrofibrillære floker intracellulært grunnet endring av tau-protein. ... -
Blood Pressure and T-Tau in Spinal Fluid Are Associated With Delayed Recall in Participants With Memory Complaints and Dementia of the Alzheimer’s Type
Hestad, Knut; Horndalsveen, Peter Otto; Engedal, Knut (Peer reviewed; Journal article, 2021)Objective: The aim of the study was to determine if systolic blood pressure (SBP), total-tau (t-tau), and beta-amyloid (Aβ) in the cerebral spinal fluid (CSF) were associated with the results on the Consortium to Establish ... -
Blood pressure in dementia, mild cognitive impairment, and subjective cognitive decline related to time of death
Hestad, Knut; Engedal, Knut; Selbæk, Geir; Strand, Bjørn Heine (Peer reviewed; Journal article, 2021)Objective: It is unknown whether systolic blood pressure (SBP) drop is part of the normal aging process or due to the onset of dementia for some people. SBP drop is referring to the decrease in blood pressure often seen ... -
Blood Pressure in Different Dementia Disorders, Mild Cognitive Impairment, and Subjective Cognitive Decline
Hestad, Knut; Engedal, Knut; Horndalsveen, Peter; Strand, Bjørn Heine (Peer reviewed; Journal article, 2020)The aim of the study was to investigate whether blood pressure (BP) differed among people with different dementia diagnoses, mild cognitive impairment, and subjective cognitive decline and whether BP differences were ... -
Blood pressure trajectories over 35 years and dementia risk: A retrospective study: The HUNT study
Selbæk, Geir; Stuebs, Josephine; Engedal, Knut; Hachinski, Vladimir; Hestad, Knut; Treviño, Cathrine Selnes; Skjellegrind, Håvard; Wedatilake, Yehani; Strand, Bjørn Heine (Peer reviewed; Journal article, 2022-09-15)High blood pressure is a well-established risk factor of dementia. However, the timing of the risk remains controversial. The aim of the present study was to compare trajectories of systolic blood pressure (SBP) over a ... -
Cognition in Patients With Memory Difficulties and Dementia Relative to APOE e4 Status
Hestad, Knut; Engedal, Knut; Horndalsveen, Peter Otto; Strand, Bjørn Heine (Peer reviewed; Journal article, 2021)The aim of this study was to investigate whether cognitive performance was equally influenced by Apolipoprotein E (APOE, with its three alleles, e2, e3, and e4) in patients with subjective cognitive decline (SCD), mild ... -
Comparison of anxiety symptoms in spouses of persons suffering from dementia, geriatric in-patients and healthy older persons
Kvaal, Kari; Engedal, Knut; Ulstein, Ingun (Journal article; Peer reviewed, 2013)Objective:To describe and compare anxiety symptoms in spouses of persons suffering from dementia, geriatric in-patients and healthy controls, and to study possible risk factors associated with anxiety in these groups of ... -
Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis
Hestad, Knut; Engedal, Knut; Aukrust, Pål; Farup, Per Grønaas; Mollnes, Tom Eirik; Ueland, Thor; Whist, Jon Elling (Journal article; Peer reviewed, 2016)Introduction: Several reports indicate that inflammation may play a role in depression and demonstrate enhanced systemic levels of inflammatory mediators. We hypothesized that 44 patients with a diagnosis of depression ... -
The effect of ApoE e4 on blood pressure in patients with and without depression
Hestad, Knut; Engedal, Knut; Whist, Jon Elling; Farup, Per Grønaas (Journal article; Peer reviewed, 2016)Introduction: Depression is considered an independent risk factor for hypertension, particularly for people with recurrent episodes or a long history of depression. Another risk factor for cardiovascular disease is the ... -
The effect of blood pressure on cognitive performance. An 8-year follow-up of the Tromsø Study, comprising people aged 45–74 Years
Hestad, Knut; Engedal, Knut; Schirmer, Henrik; Strand, Bjørn Heine (Peer reviewed; Journal article, 2020)Background: The relationship between blood pressure (BP) and cognition is complex were age appears to be an intervening variable. High and low BP have been associated with cognitive deficits as part of the aging process, ... -
The Relationships among Tryptophan, Kynurenine, Indoleamine 2,3-Dioxygenase, Depression, and Neuropsychological Performance
Hestad, Knut; Engedal, Knut; Whist, Jon Elling; Farup, Per Grønaas (Peer reviewed; Journal article, 2017)It has been suggested that the metabolic enzyme indoleamine 2,3-dioxygenase (IDO) is a biological mediator of inflammation related to the psychopathology of depression, with a Kynurenine (KYN) increase in the Tryptophan ...