Browsing Brage INN by Author "Hestad, Knut"
Now showing items 1-18 of 18
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APOE – a genetic marker of comorbidity in subjects with morbid obesity
Farup, Per Grønaas; Rootwelt, Helge; Hestad, Knut (Peer reviewed; Journal article, 2020)Background: In population-based studies, the genetic variability of the APOE E alleles have been associated with health outcomes. Health problems are common in subjects with obesity. This study explored associations between ... -
Blood Pressure in Different Dementia Disorders, Mild Cognitive Impairment, and Subjective Cognitive Decline
Hestad, Knut; Engedal, Knut; Horndalsveen, Peter; Strand, Bjørn Heine (Peer reviewed; Journal article, 2020)The aim of the study was to investigate whether blood pressure (BP) differed among people with different dementia diagnoses, mild cognitive impairment, and subjective cognitive decline and whether BP differences were ... -
Cognitive Functions and Depression in Patients with Irritable Bowel Syndrome
Farup, Per Grønaas; Hestad, Knut (Journal article; Peer reviewed, 2015-04-15)Background. Irritable bowel syndrome (IBS) is associated with depression and depression with impaired cognitive functions. The primary aim was to study associations between depression and cognitive functions in patients ... -
Effect of Age and Level of Education on Neurocognitive Impairment in HIV Positive Zambian Adults
Kabuba, Norma Namasiku Zewelanji; Menon, Anitha; Franklin, Donald R.; Lydersen, Stian; Heaton, Robert K.; Hestad, Knut (Peer reviewed; Journal article, 2018)Objective: Older age and lower education levels are known to be associated with worse neurocognitive (NC) performance in healthy adults, and individuals with HIV infection may experience accelerated brain/cognition aging. ... -
Faecal short-chain fatty acids - a diagnostic biomarker for irritable bowel syndrome?
Farup, Per Grønaas; Rudi, Knut; Hestad, Knut (Journal article; Peer reviewed, 2016)Background The diagnosis of irritable bowel syndrome (IBS) relies on symptom-based criteria. A valid and reliable biomarker that could confirm the diagnosis is desirable. This study evaluated the properties of faecal ... -
Fra ensidighet til gjensidighet: Samhandling om pasienter med langvarige og sammensatte behov
Danbolt, Lars Johan; Hestad, Knut; Kjønsberg, Kari; Kvalvik, Ann-Mari; Hynnekleiv, Torfinn (Journal article; Peer reviewed, 2016)The purpose of the study was to explore health care professionals’ experiences of collaboration across service levels concerning people with long term and complex mental disorders, and these professionals’ reflections on ... -
Functional Bowel Disorders Are Associated with a Central Immune Activation
Farup, Per Grønaas; Ueland, Thor; Rudi, Knut; Lydersen, Stian; Hestad, Knut (Peer reviewed; Journal article, 2017)Background. Subjects with depression and unexplained neurological symptoms have a high prevalence of gastrointestinal comorbidity probably related to the brain-gut communication. This study explored associations between ... -
HIV- and AIDS-associated neurocognitive functioning in Zambia - a perspective based on differences between the genders
Kabuba, Norma Namasiku Zewelanji; Menon, J. A.; Franklin, D.R. jr.; Heaton, R. K.; Hestad, Knut (Journal article; Peer reviewed, 2016)Human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) are frequently associated with neurocognitive impairment (NCI). However, few studies have examined the interrelationship between ... -
Increased frontal electroencephalogram theta amplitude in patients with anorexia nervosa compared to healthy controls
Hestad, Knut; Weider, Siri; Nilsen, Kristian Bernhard; Indredavik, Marit Sæbø; Sand, Trond (Journal article; Peer reviewed, 2016)Objective: To conduct a blind study of quantitative electroencephalogram-band amplitudes in patients with anorexia nervosa (AN) and healthy controls. Methods: Twenty-one patients with AN and 24 controls were examined with ... -
Neurocognitive Outcome and Compensating Possibilities in Children and Adolescents Treated for Acute Lymphoblastic Leukemia With Chemotherapy Only
Lofstad, Grete Elisabeth; Reinfjell, Trude; Weider, Siri; Diseth, Trond H; Hestad, Knut (Peer reviewed; Journal article, 2019)Aim: To examine the neurocognitive outcomes in children and adolescents with acute lymphoblastic leukemia (ALL) in remission who were treated with systemic chemotherapy only (CTO). Methods: Neurocognitive performances in ... -
Neuropsychological function in individuals with morbid obesity: A cross-sectional study
Sargénius; Lydersen, Stian; Hestad, Knut (Journal article; Peer reviewed, 2017)Background:Previous research has shown cognitive dysfunction to be present in a significant number ofindividuals with obesity. The objective of this study was to assess the neuropsychological profile of morbidlyobese ... -
Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis
Hestad, Knut; Engedal, Knut; Aukrust, Pål; Farup, Per Grønaas; Mollnes, Tom Eirik; Ueland, Thor; Whist, Jon Elling (Journal article; Peer reviewed, 2016)Introduction: Several reports indicate that inflammation may play a role in depression and demonstrate enhanced systemic levels of inflammatory mediators. We hypothesized that 44 patients with a diagnosis of depression ... -
PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress.
Toft, Helge Prytz; Bramness, Jørgen Gustav; Lien, Lars; Abebe, Dawit Shawel; Wampold, Bruce E.; Tilden, Terje; Hestad, Knut; Neupane, Sudan Prasad (Peer reviewed; Journal article, 2018)Background: A reciprocal relationship between activated innate immune system and changes in mood and behavior has been established. There is still a paucity of knowledge on how the immune system responds during psychiatric ... -
The effect of ApoE e4 on blood pressure in patients with and without depression
Hestad, Knut; Engedal, Knut; Whist, Jon Elling; Farup, Per Grønaas (Journal article; Peer reviewed, 2016)Introduction: Depression is considered an independent risk factor for hypertension, particularly for people with recurrent episodes or a long history of depression. Another risk factor for cardiovascular disease is the ... -
The effect of blood pressure on cognitive performance. An 8-year follow-up of the Tromsø Study, comprising people aged 45–74 Years
Hestad, Knut; Engedal, Knut; Schirmer, Henrik; Strand, Bjørn Heine (Peer reviewed; Journal article, 2020)Background: The relationship between blood pressure (BP) and cognition is complex were age appears to be an intervening variable. High and low BP have been associated with cognitive deficits as part of the aging process, ... -
The Relationships among Tryptophan, Kynurenine, Indoleamine 2,3-Dioxygenase, Depression, and Neuropsychological Performance
Hestad, Knut; Engedal, Knut; Whist, Jon Elling; Farup, Per Grønaas (Peer reviewed; Journal article, 2017)It has been suggested that the metabolic enzyme indoleamine 2,3-dioxygenase (IDO) is a biological mediator of inflammation related to the psychopathology of depression, with a Kynurenine (KYN) increase in the Tryptophan ... -
Treatment strategies in Alzheimer’s disease: a review with focus on selenium supplementation
Aaseth, Jan; Alexander, Jan; Bjørklund, Geir; Hestad, Knut; Dusek, Petr; Roos, Per M.; Alehagen, Urban (Journal article; Peer reviewed, 2016)Alzheimer’s disease (AD) is a neurodegenerative disorder presenting one of the biggest healthcare challenges in developed countries. No effective treatment exists. In recent years the main focus of AD research has been on ... -
Visual-Constructional Ability in Individuals with Severe Obesity: Rey Complex Figure Test Accuracy and the Q-Score
Sargenius, Hanna; Bylsma, Frederick; Lydersen, Stian; Hestad, Knut (Peer reviewed; Journal article, 2017)The aims of this study were to investigate visual-construction and organizational strategy among individuals with severe obesity, as measured by the Rey Complex Figure Test (RCFT), and to examine the validity of the Q-score ...