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dc.contributor.authorBjørklund, Geir
dc.contributor.authorCrisponi, Guido
dc.contributor.authorNurchi, Valeria Marina
dc.contributor.authorCappai, Rosita
dc.contributor.authorDjordjevic, Aleksandra Buha
dc.contributor.authorAaseth, Jan
dc.date.accessioned2020-03-25T13:07:28Z
dc.date.available2020-03-25T13:07:28Z
dc.date.created2019-10-06T13:00:25Z
dc.date.issued2019
dc.identifier.citationMolecules. 2019, 24:3247 (18), 1-32.en_US
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/11250/2648606
dc.description.abstractAbstract: The present article reviews the clinical use of thiol-based metal chelators in intoxications and overexposure with mercury (Hg), cadmium (Cd), and lead (Pb). Currently, very few commercially available pharmaceuticals can successfully reduce or prevent the toxicity of these metals. The metal chelator meso-2,3-dimercaptosuccinic acid (DMSA) is considerably less toxic than the classical agent British anti-Lewisite (BAL, 2,3-dimercaptopropanol) and is the recommended agent in poisonings with Pb and organic Hg. Its toxicity is also lower than that of DMPS (dimercaptopropane sulfonate), although DMPS is the recommended agent in acute poisonings with Hg salts. It is suggested that intracellular Cd deposits and cerebral deposits of inorganic Hg, to some extent, can be mobilized by a combination of antidotes, but clinical experience with such combinations are lacking. Alpha-lipoic acid (α-LA) has been suggested for toxic metal detoxification but is not considered a drug of choice in clinical practice. The molecular mechanisms and chemical equilibria of complex formation of the chelators with the metal ions Hg2+, Cd2+, and Pb2+ are reviewed since insight into these reactions can provide a basis for further development of therapeutics. Keywords: BAL; DMPS; DMSA; metal chelator; metal ion
dc.language.isoengen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleA review on coordination properties of thiol-containing chelating agents towards mercury, cadmium, and leaden_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersion
dc.source.pagenumber1-32en_US
dc.source.volume24:3247en_US
dc.source.journalMoleculesen_US
dc.source.issue18en_US
dc.identifier.doi10.3390/molecules24183247
dc.identifier.cristin1734199
cristin.unitcode209,4,7,0
cristin.unitnameInstitutt for helse- og sykepleievitenskap
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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