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dc.contributor.advisor
dc.contributor.authorPappens, Meike
dc.contributor.authorSchroijen, Mathias
dc.contributor.authorSütterlin, Stefan
dc.contributor.authorSmets, Elyn
dc.contributor.authorVan den Bergh, Omer
dc.contributor.authorThayer, Julian F.
dc.contributor.authorVan Diest, Ilse
dc.date.accessioned2015-02-06T09:58:27Z
dc.date.available2015-02-06T09:58:27Z
dc.date.issued2014
dc.identifier.issne105054
dc.identifier.urihttp://hdl.handle.net/11250/275537
dc.description.abstractThis study aimed to investigate whether interindividual differences in autonomic inhibitory control predict safety learning and fear extinction in an interoceptive fear conditioning paradigm. Data from a previously reported study (N = 40) were extended (N = 17) and re-analyzed to test whether healthy participants’ resting heart rate variability (HRV) - a proxy of cardiac vagal tone - predicts learning performance. The conditioned stimulus (CS) was a slight sensation of breathlessness induced by a flow resistor, the unconditioned stimulus (US) was an aversive short-lasting suffocation experience induced by a complete occlusion of the breathing circuitry. During acquisition, the paired group received 6 paired CS-US presentations; the control group received 6 explicitly unpaired CS-US presentations. In the extinction phase, both groups were exposed to 6 CS-only presentations. Measures included startle blink EMG, skin conductance responses (SCR) and US-expectancy ratings. Resting HRV significantly predicted the startle blink EMG learning curves both during acquisition and extinction. In the unpaired group, higher levels of HRV at rest predicted safety learning to the CS during acquisition. In the paired group, higher levels of HRV were associated with better extinction. Our findings suggest that the strength or integrity of prefrontal inhibitory mechanisms involved in safety- and extinction learning can be indexed by HRV at rest.nb_NO
dc.language.isoengnb_NO
dc.titleResting Heart Rate Variability Predicts Safety Learning and Fear Extinction in an Interoceptive Fear Conditioning Paradigmnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewed
dc.source.volume9nb_NO
dc.source.journalPLoS ONEnb_NO
dc.source.issue9nb_NO
dc.identifier.doi10.1371/journal.pone.0105054


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