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dc.contributor.authorGiroud, Sylvain
dc.contributor.authorChery, Isabelle
dc.contributor.authorArrivé, Mathilde
dc.contributor.authorProst, Michel
dc.contributor.authorZumsteg, Julie
dc.contributor.authorHeintz, Dimitri
dc.contributor.authorEvans, Alina
dc.contributor.authorGauquelin-Koch, Guillemette
dc.contributor.authorArnemo, Jon Martin
dc.contributor.authorSwenson, Jon E.
dc.contributor.authorLefai, Etienne
dc.contributor.authorBertile, Fabrice
dc.contributor.authorSimon, Chantal
dc.contributor.authorBlanc, Stéphane
dc.date.accessioned2022-05-06T13:03:35Z
dc.date.available2022-05-06T13:03:35Z
dc.date.created2021-10-01T12:17:06Z
dc.date.issued2021
dc.identifier.citationScientific Reports. 2021, 11 .en_US
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/11250/2994612
dc.description.abstractTo investigate mechanisms by which hibernators avoid atherogenic hyperlipidemia during hibernation, we assessed lipoprotein and cholesterol metabolisms of free-ranging Scandinavian brown bears (Ursus arctos). In winter- and summer-captured bears, we measured lipoprotein sizes and sub-classes, triglyceride-related plasma-enzyme activities, and muscle lipid composition along with plasma-levels of antioxidant capacities and inflammatory markers. Although hibernating bears increased nearly all lipid levels, a 36%-higher cholesteryl-ester transfer-protein activity allowed to stabilize lipid composition of high-density lipoproteins (HDL). Levels of inflammatory metabolites, i.e., 7-ketocholesterol and 11ß-prostaglandin F2α, declined in winter and correlated inversely with cardioprotective HDL2b-proportions and HDL-sizes that increased during hibernation. Lower muscle cholesterol concentrations and lecithin-cholesterol acyltransferase activity in winter suggest that hibernating bears tightly controlled peripheral-cholesterol synthesis and/or release. Finally, greater plasma-antioxidant capacities prevented excessive lipid-specific oxidative damages in plasma and muscles of hibernating bears. Hence, the brown bear manages large lipid fluxes during hibernation, without developing adverse atherogenic effects that occur in humans and non-hibernators.en_US
dc.language.isoengen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectBrown bearsen_US
dc.subjectHibernationen_US
dc.subjectatherogenic dyslipidemiaen_US
dc.titleHibernating brown bears are protected against atherogenic dyslipidemiaen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber16en_US
dc.source.volume11en_US
dc.source.journalScientific Reportsen_US
dc.identifier.doi10.1038/s41598-021-98085-7
dc.identifier.cristin1942135
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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