The persistence of anti-Spike antibodies following two SARS-CoV-2 vaccine doses in patients on immunosuppressive therapy compared to healthy controls—a prospective cohort study
Christensen, Ingrid Egeland; Jyssum, Ingrid; Tveter, Anne Therese; Sexton, Joseph; Tran, Trung; Mjaaland, Siri; Kro, Grete Anette Birkeland; Kvien, Tore Kristian; Warren, David; Jahnsen, Jørgen; Munthe, Ludvig Andre; Haavardsholm, Espen A.; Vaage, John T.; Grødeland, Gunnveig; Lund-Johansen, Fridtjof; Jørgensen, Kristin Kaasen; Syversen, Silje Watterdal; Goll, Guro Løvik; Provan, Sella Aarrestad
Peer reviewed, Journal article
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Date
2022Metadata
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Abstract
The durability of vaccine-induced humoral immunity against SARS-CoV-2 in patients with immune mediated inflammatory diseases (IMIDs) on immunosuppressive therapy is not known. The aim of this study was to compare the persistence of anti-Spike antibodies following two-dose SARS-CoV-2 vaccination between IMID patients and healthy controls and to identify factors associated with antibody decline.