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dc.contributor.authorFarup, Per Grønaas
dc.contributor.authorHestad, Knut
dc.date.accessioned2023-02-08T13:43:19Z
dc.date.available2023-02-08T13:43:19Z
dc.date.created2022-04-03T14:03:18Z
dc.date.issued2022
dc.identifier.citationApplied Sciences. 2022, 12 (5), .en_US
dc.identifier.issn2076-3417
dc.identifier.urihttps://hdl.handle.net/11250/3049368
dc.description.abstractBackground: The Kynurenine pathway (KP) is involved in various disorders, but little is known about the KP and psychosomatic complaints. The aim was to study the peripheral KP and psychosomatic comorbidity in subjects with morbid obesity. Methods: Psychosomatic comorbidity (perceived general health, muscle-skeletal pain, well-being, mood disorders, fatigue, self-esteem, sleepiness, and sense of humour) was registered, and serum samples were collected six months before and after bariatric surgery. Results: A total of 141 subjects (men/women, 116/25) with a mean age of 43.0 (SD 8.7) years and BMI of 42.1 (SD 3.8) kg/m2 were included. No significant associations were seen between the psychosomatic disorders and the KP. There was a significant downregulation of all KP metabolites after surgery, a reduction in CRP, and strong associations between CRP and the KP, particularly with the ratios of Kynurenine/Tryptophan and Quinolinic acid (QA)/Xanthurenic acid (XA). The QA/XA ratio was negatively associated with diabetes. Conclusions: The peripheral KP seemed to be of minor importance for the psychosomatic comorbidity in subjects with morbid obesity. The downregulation of all KP metabolites after bariatric surgery indicated reduced inflammation. The QA/XA ratio seemed to be a marker of insulin sensitivity and favourable glucose control.
dc.description.abstractThe Peripheral Kynurenine Pathway and Psychosomatic Comorbidity in Subjects with Morbid Obesity Undergoing Bariatric Surgery
dc.language.isoengen_US
dc.relation.urihttps://www.mdpi.com/2076-3417/12/5/2648
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleThe Peripheral Kynurenine Pathway and Psychosomatic Comorbidity in Subjects with Morbid Obesity Undergoing Bariatric Surgeryen_US
dc.title.alternativeThe Peripheral Kynurenine Pathway and Psychosomatic Comorbidity in Subjects with Morbid Obesity Undergoing Bariatric Surgeryen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersion
dc.source.pagenumber10en_US
dc.source.volume12en_US
dc.source.journalApplied Sciencesen_US
dc.source.issue5en_US
dc.identifier.doi10.3390/app12052648
dc.identifier.cristin2014871
dc.relation.projectSykehuset Innlandet HF: 2012/966
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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