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dc.contributor.authorJørgensen, Peter Godsk
dc.contributor.authorEvans, Alina L.
dc.contributor.authorKindberg, Jonas
dc.contributor.authorOlsen, Lisbeth Høier
dc.contributor.authorGalatius, Søren
dc.contributor.authorFröbert, Ole
dc.date.accessioned2020-02-17T12:13:17Z
dc.date.available2020-02-17T12:13:17Z
dc.date.created2020-01-27T09:38:48Z
dc.date.issued2020
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11250/2641965
dc.description.abstractDuring six months of annual hibernation, the brown bear undergoes unique physiological changes to adapt to decreased metabolic rate. We compared cardiac structural and functional measures of hibernating and active bears using comprehensive echocardiography. We performed echocardiography on 13 subadult free-ranging, anaesthetised Scandinavian brown bears (Ursus arctos) during late hibernation and in early summer. Mean heart rate was 26 beats per minute (standard deviation (SD): 8) during hibernation vs 71 (SD: 14) during active state. All left ventricular (LV) systolic and diastolic measures were decreased during hibernation: mean ejection fraction: 44.2% (SD: 6.0) active state vs 34.0 (SD: 8.1) hibernation, P = 0.001; global longitudinal strain: −11.2% (SD: 2.0) vs −8.8 (SD: 3.3), P = 0.03; global longitudinal strain rate: −0.82 (SD: 0.15) vs −0.41 (SD: 0.18), P < 0.001; septal e’: 9.8 cm/s (SD: 1.8) vs 5.2 (SD: 2.7), P < 0.001. In general, measures of total myocardial motion (ejection fraction and global longitudinal strain) were decreased to a lesser extent than measures of myocardial velocities. in the hibernating brown bear, cardiac adaptation included decreased functional measures, primarily measures of myocardial velocities, but was not associated with cardiac atrophy. Understanding the mechanisms of these adaptations could provide pathophysiological insight of human pathological conditions such as heart failure.
dc.language.isoeng
dc.titleCardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctos)
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.source.volume10
dc.source.journalScientific Reports
dc.identifier.doi10.1038/s41598-019-57126-y
dc.identifier.cristin1782435
dc.relation.projectAndre: Swedish Association for Hunting and Wildlife Management
dc.relation.projectAndre: Austrian Science Fund
dc.relation.projectAndre: Norwegian Directorate for Nature Management
dc.relation.projectAndre: Swedish Environmental Protection Agency
dc.relation.projectAndre: Lundbeck Foundation (R126-2012-12408)
dc.relation.projectNorges forskningsråd: xxxxxx
dc.relation.projectAndre: Nordforsk researcher network grant (project no. 44042)
cristin.unitcode209,2,3,0
cristin.unitnameInstitutt for skog- og utmarksfag
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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